Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions

Ignatius, Anita; Peraus, Manfred; Schorlemmer, Sandra; Augat, Peter; Bürger, Wolfgang; Leyen, S.; Claes, Lutz

doi:10.1016/j.biomaterials.2004.07.029

Cited by 44 publications

(41 citation statements)

References 28 publications

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“…Previous studies have shown that the bonding strength of sintered HA/Al 2 O 3 composite samples increases with an increasing Al 2 O 3 content [17]. In addition, it has been shown that Al 2 O 3 has excellent biocompatibility, mechanical strength, fatigue resistance and corrosion resistance [18,19]. It is thus one of the most frequently used materials for total hip and knee replacements and many other implant applications [20].…”

Section: Introductionmentioning

confidence: 97%

Bioactivity of fluorapatite/alumina composite coatings deposited on Ti6Al4V substrates by laser cladding

et al. 2016

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Hydroxyapatite (HA) is one of the most commonly used coating materials for metal implants. However, following high-temperature deposition, HA easily decomposes into an unstable phase or forms an amorphous phase, and hence, the long-term stability of the implant is reduced. Accordingly, the present study investigates the use of fluorapatite (FA) fortified with 20 wt% alumina (a-Al 2 O 3 ) as an alternative biomedical coating material. The coatings are deposited on Ti6Al4V substrates using a Nd:YAG laser cladding process performed with laser powers and travel speeds of 400 W/200 mm/min, 800 W/400 mm/min and 1200 W/600 mm/min, respectively. The results show that for all of the specimens, a strong metallurgical bond is formed at the interface between the coating layer and the transition layer due to melting and diffusion. The XRD analysis results reveal that the cladding layers in all of the specimens consist mainly of FA, b-TCP, CaF 2 , Ti and h-Al 2 O 3 phases. In addition, the cladding layers of the specimens prepared using laser powers of 400 and 800 W also contain CaTiO 3 and CaAl 2 O 4 , while that of the specimen clad using a power of 1200 W contains TTCP and CaO. Following immersion in simulated body fluid for 14 days, all of the specimens precipitate dense bone-like apatite and exhibit excellent bioactivity. However, among all of the specimens, the specimen that is prepared with a laser power of 800 W shows the best biological activity due to the presence of residual FA, apatite-generating CaTiO 3 and a rough cladding layer surface.

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Section: Introductionmentioning

confidence: 97%

Bioactivity of fluorapatite/alumina composite coatings deposited on Ti6Al4V substrates by laser cladding

et al. 2016

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“…[2][3][4] In the field of medical implants, precise control of cellular attachment is necessary to prevent microbiological contamination and promote proper graft response, a topic of particular interest in the area of osteogenic implantable devices. [5][6][7] Indeed, interfacial biology is a well-developed and rich field, and many types of biointerfacial modifications exist to promote the attachment and proliferation of cells on given synthetic or biomacromolecular growth substrates. 3 Techniques to induce phenotypic change and control spatial distribution in various cell types include alteration of surface topology 8 and/or degree of interchain cross-linking in a polymeric gel, 9 creation of phaseseparated amphiphilic surfaces, 10 and functionalization with cellresistant materials that restrict cell growth and enforce patterning.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Functionalization of Polymeric Cell Substrata Can Alter Mechanical Compliance

et al. 2006

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Biochemical functionalization of surfaces is an increasingly utilized mechanism to promote or inhibit adhesion of cells. To promote mammalian cell adhesion, one common functionalization approach is surface conjugation of adhesion peptide sequences such as Arg-Gly-Asp (RGD), a ligand of transmembrane integrin molecules. It is generally assumed that such functionalization does not alter the local mechanical properties of the functionalized surface, as is important to interpretations of macromolecular mechanotransduction in cells. Here, we examine this assumption systematically, through nanomechanical measurement of the nominal elastic modulus of polymer multilayer films of nanoscale thickness, functionalized with RGD through different processing routes. We find that the method of biochemical functionalization can significantly alter mechanical compliance of polymeric substrata such as weak polyelectrolyte multilayers (PEMs), increasingly utilized materials for such studies. In particular, immersed adsorption of intermediate functionalization reagents significantly decreases compliance of the PEMs considered herein, whereas polymer-on-polymer stamping of these same reagents does not alter compliance of weak PEMs. This finding points to the potential unintended alteration of mechanical properties via surface functionalization and also suggests functionalization methods by which chemical and mechanical properties of cell substrata can be controlled independently.

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“…A well-established, weight-bearing, large animal model [16][17][18] was used for investigation of the graft material. Eighteen mature female Mecklenburg sheep with an average body weight of 63 kg were operated on under general anesthesia induced by intravenous injection of propofol.…”

Section: Animal Modelmentioning

confidence: 99%

Osteogenic capacity of nanocrystalline bone cement in a weight-bearing defect at the ovine tibial metaphysis

Harms¹,

Helms²,

Taschner³

et al. 2012

IJN

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Abstract:The synthetic material Nanobone ® (hydroxyapatite nanocrystallines embedded in a porous silica gel matrix) was examined in vivo using a standardized bone defect model in the ovine tibial metaphysis. A standardized 6 × 12 × 24-mm bone defect was created below the articular surface of the medial tibia condyles on both hind legs of 18 adult sheep. The defect on the right side was filled with Nanobone ® , while the defect on the contralateral side was left empty. The tibial heads of six sheep were analyzed after 6, 12, and 26 weeks each. The histological and radiological analysis of the defect on the control side did not reveal any bone formation after the total of 26 weeks. In contrast, the microcomputed tomography analysis of the defect filled with Nanobone ® showed a 55%, 72%, and 74% volume fraction of structures with bone density after 6, 12, and 26 weeks, respectively. Quantitative histomorphological analysis after 6, and 12 weeks revealed an osteoneogenesis of 22%, and 36%, respectively. Hematoxylin and eosin sections demonstrated multinucleated giant cells on the surface of the biomaterial and resorption lacunae, indicating osteoclastic resorptive activity. Nanobone ® appears to be a highly potent bone substitute material with osteoconductive properties in a loaded large animal defect model, supporting the potential use of Nanobone ® also in humans.

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Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions

Cited by 44 publications

References 28 publications

Bioactivity of fluorapatite/alumina composite coatings deposited on Ti6Al4V substrates by laser cladding

Bioactivity of fluorapatite/alumina composite coatings deposited on Ti6Al4V substrates by laser cladding

Biochemical Functionalization of Polymeric Cell Substrata Can Alter Mechanical Compliance

Osteogenic capacity of nanocrystalline bone cement in a weight-bearing defect at the ovine tibial metaphysis

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