Osseointegration of different implant surfaces in areas grafted with deproteinized bovine bone associated or not with fresh bone marrow—Preclinical study in rabbits

Abstract

Objectives: To assess the influence of two different implant surfaces on osseointegration in maxillary sinuses of rabbits previously grafted with deproteinized bovine bone (DBB) associated or not with fresh bone marrow (BM).Material and methods: Sixteen New Zealand albino rabbits (males, 3.5/4.5 kg and 9-12 months old) were randomly divided into two groups with 8 rabbits each, according to the type of association of biomaterials used to fill the animals' maxillary sinuses: DBB (Deproteinized Bovine Bone) and DBB/BM (Deproteinized bovine bone associated with fresh autologous bone marrow). Ninety (90) days following the grafting procedure, the animals received implants in the area with two different microstructures (SA-Sandblasting + acid attack and SA-H-Sandblasting + acid attack + immersion in 0.9% sodium chloride isotonic solution). All rabbits were euthanized 90 days after implant placement. The microtomographic analysis was performed to verify the number of mineralized tissues around the implants throughout their length (%BV/ TV), while the histomorphometric analysis was performed to verify the percentage of bone-implant contact around the implants throughout their length (%BIC). Results:We observed no differences in the quantity for %BV/TV

Clinical and radiographic outcomes of lateral sinus floor elevation with simultaneous hydrophilic implants placement: A retrospective study of 2–5 years

“…Meanwhile, Leocadio et al. (2021) also found no difference in the number of mineralized bone and BIC% between the two implants 90 days after SFE in rabbits. They argued that BIC after SFE was not influenced by implant surfaces.…”

Osseointegration Potential Assessment of Bone Graft Materials Loaded with Mesenchymal Stem Cells in Peri-Implant Bone Defects

“…Scaffolds, cells, and molecular elements are used or assembled for therapeutic applications in bone tissue engineering. Mesenchymal stem cells (MSCs) are undifferentiated cells with high self-renewal capacity, multipotent differentiation potential, and immunomodulatory and regenerative properties, making them valuable for research and clinical application [21][22][23]. Many studies have evaluated the use of BGMs combined with bone marrow-derived MSCs (BMSCs) in the reconstruction of bone defects and osseointegration enhancement [24][25][26].…”