Osseointegration of machined, injection moulded and oxygen plasma modified PEEK implants in a sheep model

Poulsson, Alexandra H.C.; Eglin, David; Zeiter, Stephan; Camenisch, Karin; Sprecher, Christoph M.; Agarwal, Yash; Nehrbass, Dirk; Wilson, J. C. Avelar-Batista; Richards, R. Geoff

doi:10.1016/j.biomaterials.2013.12.056

Cited by 140 publications

(78 citation statements)

References 40 publications

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“…The binary scaffold composed of PEEK and β‐TCP may theoretically combine the appropriate mechanical properties of PEEK and the good bioactivity and biodegradability of β‐TCP. While in fact PEEK acts as a closed membrane in which β‐TCP is completely wrapped after the melting/solidifying processing, plus PEEK membrane almost does not degrade,3 making it difficult for the binary scaffold to exhibit the bioactivity and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

et al. 2018

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Polyetheretherketone (PEEK)/β‐tricalcium phosphate (β‐TCP) scaffolds are expected to be able to combine the excellent mechanical strength of PEEK and the good bioactivity and biodegradability of β‐TCP. While PEEK acts as a closed membrane in which β‐TCP is completely wrapped after the melting/solidifying processing, the PEEK membrane degrades very little, hence the scaffolds cannot display bioactivity and biodegradability. The strategy reported here is to blend a biodegradable polymer with PEEK and β‐TCP to fabricate multi‐material scaffolds via selective laser sintering (SLS). The biodegradable polymer first degrades and leaves caverns on the closed membrane, and then the wrapped β‐TCP is exposed to body fluid. In this study, poly(l‐lactide) (PLLA) is adopted as the biodegradable polymer. The results show that large numbers of caverns form on the membrane with the degradation of PLLA, enabling direct contact between β‐TCP and body fluid, and allowing for their ion‐exchange. As a consequence, the scaffolds display the bioactivity, biodegradability and cytocompatibility. Moreover, bone defect repair studies reveal that new bone tissues grow from the margin towards the center of the scaffolds from the histological analysis. The bone defect region is completely connected to the host bone end after 8 weeks of implantation.

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Section: Introductionmentioning

confidence: 99%

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

et al. 2018

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“…Polyaryl-ether-ether-ketone (PEEK), a class of high-performance thermoplastic candidate for replacing metal implants, especially in orthopedics [3,4] and trauma [5,6], is also subjected to such tribological issues [7,8]. Especially those devices are often subjected to biological fluids, and amorphous graphite-like carbon film, by contrast, is believed to be one of the optimum candidates for the modification of PEEK, due to its adaptive ability to the humidity even water environment in terms of low friction coefficient and specific wear rate as well as good anti-corrosive capability [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Tribological Properties of Si-Doped Graphite-Like Amorphous Carbon Film of PEEK Rubbing with Different Counterparts in SBF Medium

et al. 2015

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The present investigation has been conducted in order to evaluate the friction and wear behaviors of polyaryl-ether-ether-ketone coated with a Si/GLC film sliding against 100Cr6 steel, Al 2 O 3 and Si 3 N 4 balls in a biological medium of simulated body fluid, using the ballon-disk tribological tests. The test results show that the wear volume loss of the rubbing pairs is two orders of magnitude greater than that determined for the tribo-pairs in SBF lubrication, coefficient of friction decreases by 50 % at least, as compared to that in dry conditions. The friction coefficient showed the same varied trend with Hertzian contact radius. The wear rate showed the inverse varied trend with the contact pressure. The interfacial tribochemically reacted with moisture available in SBF medium plays an effect role of the difference in the wearresistant and lubricating behavior. Furthermore, some indexes including hardness ratio of pair and film were employed to predict the wear behavior of GLC composite films sliding against different counterparts. The Si/GLC nanocomposite films would be a new kind of promising materials applied to artificial heart valves and stents.

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“…Surface modifications such as plasma or chemical etching [10–12], addition of bioactive coatings [13, 14], and PEEK composites have performed well in vitro and in vivo [15], yet their clinical success may be limited due to their potential instability and delamination in physiological or surgical environments [16, 17]. Introducing bulk porosity throughout PEEK implants via powder sintering (or compression molding) aims to increase implant fixation by encouraging the migration and proliferation of various cell types to enhance vascular and bone tissue ingrowth [3, 18].…”

Section: Introductionmentioning

confidence: 99%

High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants

Evans

Torstrick

Lee³

et al. 2015

Acta Biomaterialia

177

140

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Despite its widespread clinical use in load-bearing orthopaedic implants, polyether-ether-ketone (PEEK) is often associated with poor osseointegration. In this study, a surface porous PEEK material (PEEK-SP) was created using a melt extrusion technique. The porous layer thickness was 399.6±63.3 µm and possessed a mean pore size of 279.9±31.6 µm, strut spacing of 186.8±55.5 µm, porosity of 67.3±3.1%, and interconnectivity of 99.9±0.1%. Monotonic tensile tests showed that PEEK-SP preserved 73.9% of the strength (71.06±2.17 MPa) and 73.4% of the elastic modulus (2.45±0.31 GPa) of as-received, injection molded PEEK. PEEK-SP further demonstrated a fatigue strength of 60.0 MPa at one million cycles, preserving 73.4% of the fatigue resistance of injection molded PEEK. Interfacial shear testing showed the pore layer shear strength to be 23.96±2.26 MPa. An osseointegration model in the rat revealed substantial bone formation within the pore layer at 6 and 12 weeks via µCT and histological evaluation. Ingrown bone was more closely apposed to the pore wall and fibrous tissue growth was reduced in PEEK-SP when compared to non-porous PEEK controls. These results indicate that PEEK-SP could provide improved osseointegration while maintaining the structural integrity necessary for load-bearing orthopaedic applications.

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Osseointegration of machined, injection moulded and oxygen plasma modified PEEK implants in a sheep model

Cited by 140 publications

References 40 publications

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

Tribological Properties of Si-Doped Graphite-Like Amorphous Carbon Film of PEEK Rubbing with Different Counterparts in SBF Medium

High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants

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