Osseous Findings in Sickle Cell Disease

Kennedy, Daniel P.; Hooker, Jeffrey D.; Morris, Robert W.

doi:10.37549/ar2638

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first case involved a 21-year-old female with sickle cell anemia with multiple discrete splenic and hepatic masses, favored to represent areas of EH. Although cases of EH are commonly found in patients with various hemoglobinopathies, it is less common in sickle cell anemia when compared to other hemoglobinopathies such as beta thalassemia [4] . Splenic and hepatic involvement in EH that presents as a discrete mass rather than diffuse visceromegaly is even more uncommon [1] .…”

Section: Discussionmentioning

confidence: 99%

Abnormal imaging presentations of extramedullary hematopoiesis in a 21-year old and 72-year old female

Kaechele

Chawla²,

Osher³

2022

Radiology Case Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Abnormal imaging presentations of extramedullary hematopoiesis in a 21-year old and 72-year old female

Kaechele

Chawla²,

Osher³

2022

Radiology Case Reports

View full text Add to dashboard Cite

Hair-on-End Sign in a 9-Year-Old Girl Presenting with Acute Stroke in Sickle Cell Disease

Ogwang¹,

Odongo²,

Namusisi³

et al. 2022

IMCRJ

View full text Add to dashboard Cite

Background The hair-on-end (HOE) sign is a rare finding seen in the diploic space on skull radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) with the appearance of long, thin vertical striations of calcified spicules perpendicular to the bone surface that looks like hair standing on end. It is classically seen in children/adolescents with hemolytic anemias, in particular, thalassemia major and sickle cell disease. Here, we present a 9-year-old Ugandan girl who presented with stroke in whom head CT demonstrated cerebral intraparenchymal hemorrhage and multiple infarcts on the left with HOE sign. Hb electrophoresis confirmed the diagnosis of sickle cell anemia. Case Summary We present a 9-year-old Ugandan girl who presented with an unexplained stroke that preceded an episode of acute headache, vomiting, followed by focal convulsions and altered consciousness. Clinical findings revealed severe pallor of the conjunctivae and mild scleral icterus. CT demonstrated right cerebral intraparenchymal hemorrhage, multiple high cerebral infarcts on the right and evidence of extra medullary hematopoiesis with a classical HOE sign. Hemoglobin (Hb) electrophoresis confirmed sickle cell disease (SCD). The child was then initiated on hydroxyurea, antibiotics, analgesics and intravenous fluids. She improved and was discharged 16 days later. Follow-up of the child was uneventful. Conclusion HOE sign is a complication of chronic hemolysis usually seen in patients with thalassemia and sickle cell anemia. It is a rare finding that clinicians should be well conversant with, especially in Africa where sickle cell disease is common.

show abstract

Osseous Findings in Sickle Cell Disease

Cited by 2 publications

References 12 publications

Abnormal imaging presentations of extramedullary hematopoiesis in a 21-year old and 72-year old female

Abnormal imaging presentations of extramedullary hematopoiesis in a 21-year old and 72-year old female

Hair-on-End Sign in a 9-Year-Old Girl Presenting with Acute Stroke in Sickle Cell Disease

Contact Info

Product

Resources

About