Osseous Healing in Foot and Ankle Surgery with Autograft, Allograft, and Other Orthobiologics

Yeoh, Jane; Taylor, Brandon A.

doi:10.1016/j.ocl.2017.03.009

Cited by 13 publications

(6 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The success of arthrodesis depends on several factors including patient selection and patient comorbidities. Individuals with comorbidities associated with poor surgical healing or with local healing problems are predisposed to a high rate of delayed and non-union [5,7]. However, known risk factors for non-union were not found to be associated with healing for the LIPUS patients in the present study, which suggests the possibility that LIPUS was able to mitigate potential patient risk factors.…”

Section: Diabetescontrasting

confidence: 62%

“…Majeed et al also observed that nine of twelve diabetic patients attained union following EXOGEN treatment for symptomatic and radiological nonunion for a variety of foot and ankle pathologies [16]. In addition to comorbid diseases, previous attempted fusion is a risk factor for non-union [7]. O'Connor et al reported a lower union rate of 77% for revision arthrodesis in the foot and ankle [10].…”

Section: Diabetesmentioning

confidence: 99%

“…Surgical foot/ankle arthrodesis augmented with autograft and/or allograft have yielded union rates as low as 75% [6]. Several recombinant human platelet-derived growth factor-enriched bone grafts have also been approved for use in foot and ankle applications [7], but the clinical outcomes have been mixed. One study reported union in 303 of 370 (81.9%) of patients [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Union of foot/ankle Arthrodesis: A Registry Study of Low-intensity Pulsed Ultrasound (LIPUS)

White¹,

Lau²,

Ong³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Bone grafts and bone stimulation devices are used as adjuncts to foot/ankle arthrodesis to improve healing and reduce revision risk. Union rates of low-intensity pulsed ultrasound (LIPUS) and the factors associated with improved healing were evaluated. Methods: From a prospective arthrodesis/fracture registry for EXOGEN (Bioventus LLC), treatment success for foot/ankle arthrodesis patients were was evaluated, based on both clinical (solid and pain-free on manual stress) and radiological (3 of 4 cortices bridging) criteria. Associations between union rates and surgical treatments, comorbidities, and medications were tested.Results: EXOGEN was used by a total of 235 primary and 16 revision foot/ankle arthrodesis patients. Of these, 41.4% used EXOGEN within 90 days of the fracture/arthrodesis. EXOGEN use within 90 days of the fracture/arthrodesis was associated with improved union rates (overall group (p=0.004, odds ratio (OR) 3.675 (95% CI: 1.459-9.258)); primary group (p=0.007, OR 3.383 (95% CI: 1.335-8.574))). The overall union rate was 86.9% (primary: 86.4%; revision: 93.8%). Patients with the comorbidity of diabetes, obesity, or current smoker were not associated with a higher non-union rate (p=0.779). Other comorbidities were not associated with increased non-union rates (Charcot disease p=0.614, NSAID p=0.862, steroids p=0.647). For all patients, union rates were 94.2% (EXOGEN use ≤90 days post-fracture/arthrodesis) and 81.6% (>90 days). Conclusions: Union rates for foot/ankle arthrodesis with adjunctive LIPUS were comparable to other therapies. Known patient risk factors for non-union were not found to be associated with impaired healing for the LIPUS patients, suggesting the possibility that LIPUS may mitigate these known risk factors.

show abstract

Section: Diabetescontrasting

confidence: 62%

Section: Diabetesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Union of foot/ankle Arthrodesis: A Registry Study of Low-intensity Pulsed Ultrasound (LIPUS)

White¹,

Lau²,

Ong³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“… 16 , 17 Furthermore, other orthobiologics and other synthetic bone grafts including cellular bone allograft containing mesenchymal stem cells, bone marrow aspirate, platelet-derived growth factor, platelet-rich plasma, bone morphogenetic protein, fatal tissue, and demineralized bone matrix are also recommended for foot and ankle surgery. 18 – 20 However, at present, there are many actual cases for which allografts and other orthobiologics are not available in Japanese hospitals or Japanese health insurance systems. In such situations, combination of calcaneal bone with IP-CHA (NEOBONE®) was also useful for relatively larger bony defects (1.5–2.0 cm) in subtalar joint.…”

Section: Discussionmentioning

confidence: 99%

Use of autologous bone grafting from the calcaneus and interconnected porous hydroxyapatite ceramic for bone transplantation in rheumatoid foot surgery

Hirao

Ebina

Etani

et al. 2018

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Cancellous bone grafts from the calcaneus have been used for the foot and ankle as well as iliac bone graft; however, there is a sparse report for calcaneal bone transplantation in the field of rheumatoid foot surgery. In this study, safety and usefulness of calcaneal bone grafts, and combination with interconnected porous hydroxyapatite ceramic, was evaluated in rheumatoid arthritis foot surgeries. Of six rheumatoid arthritis cases, three (talo-navicular joint fusion) used a calcaneal bone graft alone, and the remaining three cases (subtalar joint and talo-navicular joint fusion) used a combination of calcaneal bone graft and interconnected porous hydroxyapatite ceramic augmented with dense calcium hydroxyapatite for subtalar bony defect (1.5–2.0 cm) after the correction. Pre- and postoperative Japanese Society for Surgery of the Foot rheumatoid arthritis foot ankle scale scores were obtained for the clinical assessment. As radiographic assessment, tibio-calcaneal angle, calcaneal pitch, talo-1st metatarsal angle, and pronated foot index were also evaluated. After starting weight-bearing or walking, there was no pain and skin trouble at the fusion and harvesting sites. All cases achieved bony fusion within 6–10 weeks. Japanese Society for Surgery of the Foot rheumatoid arthritis foot ankle score was improved in all six cases. Furthermore, tibio-calcaneal angle, talo-1st metatarsal angle, and pronated foot index were also improved at latest follow-up in all cases. In conclusion, autologous bone grafting from the calcaneus was safe and convenient even in rheumatoid foot surgeries. For larger bony defects (1.5–2.0 cm), combination use with interconnected porous hydroxyapatite ceramic augmented with dense calcium hydroxyapatite was also useful.

show abstract

“…They are widely used in osteoarticular reconstructive surgery, in hospitals with a bone bank, given their ease of use and good results in bone fractures and defects filling [26,27]. They are also the most common type currently used in foot and ankle surgery [28]. Their limitations are related to the quality of the regenerated bone tissue that is not always predictable due to its limited osteoinduction, in addition to requiring costly and laborious processing to eliminate its antigenic capacity [23].…”

Section: Bone Grafts: Limitations Of Auto and Allograftsmentioning

confidence: 99%

Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration

et al. 2019

View full text Add to dashboard Cite

Bioceramic scaffolds are crucial in tissue engineering for bone regeneration. They usually provide hierarchical porosity, bioactivity, and mechanical support supplying osteoconductive properties and allowing for 3D cell culture. In the case of age-related diseases such as osteoarthritis and osteoporosis, or other bone alterations as alveolar bone resorption or spinal fractures, functional tissue recovery usually requires the use of grafts. These bone grafts or bone void fillers are usually based on porous calcium phosphate grains which, once disposed into the bone defect, act as scaffolds by incorporating, to their own porosity, the intergranular one. Despite their routine use in traumatology and dental applications, specific graft requirements such as osteoinductivity or balanced dissolution rate are still not completely fulfilled. Marine origin bioceramics research opens the possibility to find new sources of bone grafts given the wide diversity of marine materials still largely unexplored. The interest in this field has also been urged by the limitations of synthetic or mammalian-derived grafts already in use and broadly investigated. The present review covers the current stage of major marine origin bioceramic grafts for bone tissue regeneration and their promising properties. Both products already available on the market and those in preclinical phases are included. To understand their clear contribution to the field, the main clinical requirements and the current available biological-derived ceramic grafts with their advantages and limitations have been collected.

show abstract

Osseous Healing in Foot and Ankle Surgery with Autograft, Allograft, and Other Orthobiologics

Cited by 13 publications

References 51 publications

Union of foot/ankle Arthrodesis: A Registry Study of Low-intensity Pulsed Ultrasound (LIPUS)

Union of foot/ankle Arthrodesis: A Registry Study of Low-intensity Pulsed Ultrasound (LIPUS)

Use of autologous bone grafting from the calcaneus and interconnected porous hydroxyapatite ceramic for bone transplantation in rheumatoid foot surgery

Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration

Contact Info

Product

Resources

About