Osseous Metaplasia and Subsequent Spontaneous Pregnancy Chance: A Case Report and Review of the Literature

Abstract

Backgrounds: What is not clear as yet is not only the etiology, but also the management of osseous metaplasia. We describe an infertile patient with osseous metaplasia and subsequent pregnancy after treatment and review the literature from infertility perspective. Method: We presented a 30-year-old woman with 8 years of secondary infertility who conceived spontaneously after removal of osseous tissue by operative hysteroscopy (HS) following one failed in vitro fertilization cycle. The current literature regarding the osseous metaplasia and fertility potential after removal of osseous tissue was also systematically reviewed in which 21 reports (n = 64 women) were eligible. Results: The available data suggest that restoration of endometrial cavity with HS or curettage provides a spontaneous pregnancy rate of 54.2% within 12 months. Conclusion: According to the available data, irrespective from the duration of subfertility, spontaneous pregnancy should be expected for at least 1 year following the ‘complete' restoration of endometrial cavity. In that context, further infertility treatments such as assisted reproduction cycles should be postponed, unless there is another reason for infertility.

Osseous endometrium presenting as menorrhagia, successful outcome by hysteroscopy: a case report and review

“…Bozdag et al have reported that restoration of endometrial cavity with hysteroscopy or curettage provides a spontaneous pregnancy rate of 54.2% within 12 months. 12 They also recommended that irrespective from the duration of subfertility, assisted reproduction cycles should be postponed, unless there is another reason for infertility. That spontaneous pregnancy can be expected within a year of normal restoration of endometrial cavity.…”

Diagnosis and Management of Craniofacial Osteomas

“…3,5 Heteroplastic osteomas can occur in tissues other than bone, such as skin 7,8 and mucosa tissue. 9 Several studies report heterotopic ossification and calcification in cutaneous, 7,8 oral, 9,10 genital, cervical, 11 salpingeal, 12 endometrial, [13][14][15] and orbital regions, [16][17][18] and in rare cases, gastrointestinal and pulmonary structures.…”