Osseous metaplasia of the endometrium: A multicenter retrospective study

Garzon, Simone; Laganà, Antonio Simone; Carugno, Josè; Font, Enric Cayuela; Jiménez, Junior Vega; Kar, S.; Fikri, Jamal; Pons, Juan Carlos; Milind, Telang; Medvedied, Mykhailov; Pacheco, Luis Alonso; Salazar, Esmely; Montevecchi, L; Ochoa, C.; DeAngelis, Carlo

doi:10.1016/j.ejogrb.2021.08.032

Cited by 8 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osseous metaplasia of the uterus is a rare clinical entity and there are likely many undiagnosed cases. Eighty-seven percent of cases occur after a previous pregnancy, and it has a strong association with secondary infertility as described above 1 . The most common hypothesis for the aetiology of this pathology is that it occurs due to persistence of embryonic foetal bone after pregnancy 7 .…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Osseous metaplasia of the uterus; an interesting presenting complaint and case of secondary infertility – case report

Rudd

Pujari

2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Introduction and importance: Little is known about the rare condition, osseous metaplasia of the uterus, with few cases described worldwide. It is a non-neoplastic transformation in which endometrial stroma is replaced with a mix of bone and cartilage. Occurring commonly after pregnancy, it is thought that the persistence of foetal embryonic remnants contributes to this change. If untreated, osseous metaplasia of the uterus can have a major impact on a woman’s fertility. Case presentation: The authors present a case of a woman with the feeling of a foreign body in the vagina and a long-standing history of secondary infertility of unknown cause. She was found to have osseous metaplasia of the uterus with spontaneous expulsion of the bony fragments from the uterus into the cervical canal, creating the sensation of foreign body in the vagina. She was treated with hysteroscopic resection. Fertility returned 3 months post procedure. Clinical discussion: This case provides a valuable reminder that osseous metaplasia can have a varied clinical presentation and requires a careful history and examination. Conclusion: This case reinforces the importance of a thorough diagnostic assessment in the woman presenting with foreign body in the vagina/cervix and /orsecondary infertility. This rare but important diagnosis can have a lasting impact on a woman’s reproductive health if left untreated.

show abstract

Section: Discussionmentioning

confidence: 89%

“…Osseous metaplasia of the uterus is a rare condition with a reported incidence of about 1 in 10 000 hysteroscopic cases 1 . It is an unusual pathology and has a strong association with secondary infertility 2 , 3 .…”

Section: Introductionmentioning

confidence: 99%

Osseous metaplasia of the uterus; an interesting presenting complaint and case of secondary infertility – case report

Rudd

Pujari

2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

show abstract

“…The procedure had been performed at 17 weeks and though uncomplicated, may well have led to retained products of conception that remained quiescent or at least, asymptomatic until the current presentation. Anomalous, intra-uterine bony material may also occur de novo as a rare form of endometrial metaplasia [9][10][11]. In such examples, it can be distinguished from foetal remnants by its continuity with underlying endometrial stroma [12].…”

Section: Discussionmentioning

confidence: 99%

Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease

Aboda¹,

Kim²,

Xu³

et al. 2022

austinjclincaserep

View full text Add to dashboard Cite

Uterine foreign bodies are a rare, but important cause of infertility and pelvic pain. Due to their relative scarcity, the diagnosis may be either missed or simply not considered as contributory to aetiology when patients present with symptoms. We report the case of a 42-year-old woman diagnosed with Atypical Pelvic Inflammatory Disease (APID). She presented with lower abdominal pain, vaginal discharge and inflammatory markers consistent with acute infection. Paradoxically, diagnostic imaging revealed an unsuspected intrauterine foreign body. The significance of this to the presenting complaint was initially uncertain however conservative management with antibiotics alone was sufficient to allow complete recovery. Later, the patient consented to operative hysteroscopy which identified and removed the object which was shown by histology to be a residual bone fragment derived most probably, from retained products of conception. The patient was noted to have had a surgical termination of pregnancy 5 years prior.

show abstract

“…Its pathogenesis is not clear, but the most widely accepted theory is metaplasia of the stromal cells into osteoblasts, which produce osseous tissue [2,3,7]. Most of the patients belong to the reproductive age group [3,4,8] and presented with infertility with a prior history of either therapeutic or spontaneous first-trimester abortion [3,4,6,[8][9][10]. The presence of bone in the endometrium can be confirmed through ultrasound, hysteroscopy, or histopathological examination (HPE) following a biopsy or curettage.…”

Section: Introductionmentioning

confidence: 99%

“…The presence of bone in the endometrium can be confirmed through ultrasound, hysteroscopy, or histopathological examination (HPE) following a biopsy or curettage. Management includes hysteroscopic evacuation of these bony spicules [7,8,10] and most of the patients are able to conceive after the evacuation [2,4,6,[8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Osseous Metaplasia of the Endometrium: A Rare Pathological Entity

Devdhar,

Gupta,

Gautam

et al. 2024

Cureus

View full text Add to dashboard Cite

Osseous metaplasia of the endometrium: A multicenter retrospective study

Cited by 8 publications

References 25 publications

Osseous metaplasia of the uterus; an interesting presenting complaint and case of secondary infertility – case report

Osseous metaplasia of the uterus; an interesting presenting complaint and case of secondary infertility – case report

Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease

Osseous Metaplasia of the Endometrium: A Rare Pathological Entity

Contact Info

Product

Resources

About