Ossifying fibroma

Abstract

Our experience includes seven cases of ossifying fibroma. The condition also appears in the literature under diagnostic names such as congenital fibrous dysplasia, congenital osteitis fibrosa, congenital fibrous defect of the tibia, and osteofibrous dysplasia of the tibia and fibula. The lesions develop in childhood and are located in the diaphysis of the tibia, or fibula. Of seven patients, we performed wide excision with free vascularized fibular graft in five cases, wide resection of the distal one-third of the fibula in one case, and curettage and bone graft in one case. Two of the patients who had wide excision with free vascularized fibular graft had recurrence. One case of recurrence occurred where incomplete wide excision with free-vascularized fibular graft was performed because the lesion was too close to the distal epiphysis of the tibia. One of the patients who had curettage and bone graft also had recurrence. It was concluded that children who have an ossifying fibroma requiring surgery can safely be treated with wide excision with or without free-vascularized fibular graft.

Ossifying Fibroma in a Canary (Serinus canaria)

“…The tibia may reveal slight or moderate anterior or anterolateral bowing with or without pathologic fractures. 2 In young horses, the mandible is usually affected, and the condition is called equine juvenile mandibular ossifying fibroma. 4 There are reports of occurrences of ossifying fibroma in ruminants, 5 cats, 6 and dogs.…”

“…In humans, the most common sites of involvement are the head and neck region, and rarely in long bones, such as tibia, fibula, or other tubular bones. 2,3 Ossifying fibromas of the long bones of the leg usually occur in the pediatric age group. These lesions are typically benign, slowgrowing neoplasms.…”

Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina

“…Three years after the fracture almost complete remission of the lesion was observed. It has been postulated that the periosteum plays a main role in the pathogenesis of OF (5). The periosteum is a complex structure composed of an outer fibrous layer predominantly consisting of collagen that lends structural integrity, and a highly cellular inner layer of mesenchymal progenitor cells that possess the potential to differentiate into osteoblasts or fibroblasts (6).…”

“…Although the pathogenesis of OF is unknown, it has been postulated that it is the result of excessive resorption of bone secondary to defective bone, probably in an attempt at healing by fibrous repair. The basic defect would be located in the periosteum, producing abnormal osteoblasts or an excessive number of osteoclasts (5). The natural history of OF is progression of the lesion until the age of 10 years.…”

Juvenile Psammomatoid Ossifying Fibroma — A Rare Entity

“…According to Kempsoh [5] -bone deposition and resorption occurring on the same spicules of the bone. It was postulated that ossifying fibroma resulted from excessive resorption of bone with fibrous repair of the defect.…”