Ossifying fibromyxoid tumor: a rare case

Abstract

Ossifying fibromyxoid tumour (OFMT) is a rarely occurring soft tissue neoplasm of mesenchymal origin. It is a rarely found tumour with intermediate behaviour and differentiation. Although it is mostly benign, malignant variants also exist. We are presenting a case of 32-year-old man presented in clinic with complaints of painless swelling in left distal thigh. After reviewing his X-ray, a diagnostic biopsy was planned which came out to be suspicious of solitary fibrous tumour. Other radiological workup was done and the patient was planned to undergo wide margin excision. The final histopathology showed a diagnosis of OFMT of soft tissue, atypical variant. The patient is under follow-up and is disease free. This type of tumour possesses potential of local recurrence and metastases; therefore, it is important to keep a long-term follow-up of patient.

Ossifying fibromyxoid tumor in the lower extremity mimicking a sebaceous cyst. Case report and literature review

“…When CT is not conclusive, MRI can be utilized, where OFMT usually appears isointense to muscles on T1-weighted images and shows intermediate to high signal intensity on T2-weighted images due to high degree of vascularity in the atypical variant, which may suggest hemorrhage, leading to a differential diagnosis of myositis ossificans or ossifying hematoma [ 7 ]. Table 1 depicts that the only reported case of thigh OFMT during the last 2 decades had preoperative MRI assessment, and showed findings in agreement with the above-mentioned MRI description [ 10 ].…”

“…The proliferation fraction (Ki67) was less than 1%. Our case resulted to be of the typical variant as most of the reported OFMT cases in Table 1 [ [12] , [13] , [14] , [15] , [16] ], with the exception of two patients that were atypical and malignant variants respectively [ 10 , 11 ].…”

“…Table 1 reveals that in most of the cases, the main presentations agree with such description. However, one patient had no significant clinical findings [ 10 ].…”

“…Our patient's specimen was of the typical variant and though it is only recommended that only the atypical and malignant variants should have long follow-up, our patient was followed for 40 months during which he underwent MRI and US with no signs of recurrence. Most of the reported cases ( Table 1 ) were typical with the exception of two cases: an atypical variant followed up for 24 months with no recurrence [ 10 ]; and a malignant variant where neither the duration nor the follow-up outcomes were reported [ 11 ].…”