Ossifying Fibromyxoid Tumor Misdiagnosed as Follicular Neoplasia

Lax, Sigurd; W, Langsteger

doi:10.1159/000333485

Cited by 14 publications

(23 citation statements)

References 6 publications

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“…There are only two descriptions of OFMT in cytology literature to date. 7,8 The FNA cytology in the index case is almost exactly similar to those reported earlier. All the cases showed moderate to high cellularity and fibrillar dense matrix material, with small clusters and singly dispersed uniform neoplastic cells floating within.…”

Section: Discussionsupporting

confidence: 84%

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Cytologic diagnosis of ossifying fibromyxoid tumor of soft tissue: A case report

Mohanty

Srinivasan

Rajwanshi

et al. 2003

Diagnostic Cytopathology

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Ossifying fibromyxoid tumor (OFMT) of soft tissue is an uncommon, recently described neoplasm. It is usually, but not universally, a benign neoplasm and cases of metastatic so-called "malignant OFMT" have been reported. Although the histopathologic features of OFMT are well characterized, the same is not entirely true so far as the cytology literature is concerned. There are only three cytologic descriptions of OFMT to date to the best of our knowledge. A 62-year-old woman presented with a subcutaneous well-circumscribed nodular soft tissue mass at the upper end of the shoulder. X-ray and computed tomography revealed an incomplete shell of calcification surrounding the nodular mass along with foci of ossification within it. Fine-needle aspiration (FNA) cytology showed round to polygonal to spindle shaped neoplastic cells arranged in clusters, cords, and small aggregates and lying discretely in a mucoid background. Some osteoid-like material was also seen. The tumor was completely excised and histopathologic examination confirmed the diagnosis of OFMT. OFMT should be considered as a possibility in FNA cytology of myxoid soft tissue tumor especially with radiologic evidence of ossification.

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Section: Discussionsupporting

confidence: 84%

“…To the best of our knowledge, only one case of ordinary (benign) OFMT and one case of malignant variant of OFMT have been illustrated in the cytology literature. 7,8 Herein we report a case of ossifying fibromyxoid tumor of soft tissue with special emphasis on cytomophologic features.…”

mentioning

confidence: 99%

Cytologic diagnosis of ossifying fibromyxoid tumor of soft tissue: A case report

Mohanty

Srinivasan

Rajwanshi

et al. 2003

Diagnostic Cytopathology

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“…1,6,7 Its cytomorphologic features have rarely been reported, however. 8,9 This is the first report on fine needle aspiration (FNA) cytology of the malignant variant of OFMT; it occurred in a 70-year-old man.…”

Section: Background: Ossifying Fibromyxoid Tumor (Ofmt) Of Soft Partsmentioning

confidence: 99%

“…8 FNA smears (Giemsa stain) show fine fibrillary, pink matrix and moderate cellularity containing slightly pleomorphic, small to medium-sized, round to oval cells with fine chromatin, arrayed in small groups occasionally forming rosettelike structures. 9 The FNA cytologic findings of OFMT provide the first study of the cytologic appearance of the malignant variant. FNA smears were cellular, showing loosely cohesive clusters and a cordlike arrangement as well as a large number of singly dispersed tumor cells, with scattered, dense stromal fragments and a slightly myxoid background.…”

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confidence: 99%

Fine Needle Aspiration Cytology of the Malignant Variant of Ossifying Fibromyxoid Tumor of Soft Parts

et al. 2001

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“…[3–5] Cytological features of four cases have been reported. [6–9] We present a further case evaluated during an intraoperative consultation. It is our experience that cytological findings coupled with characteristic peripheral ossification seen on image studies or macroscopically may lead to suspect this peculiar neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Cytological features of ossifying fibromyxoid tumor of soft parts

Álvarez-Rodríguez¹,

Ja²,

Salas³

et al. 2012

J Cytol

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A case of ossifying fibromyxoid tumor (OFMT) evaluated during an intraoperative pathological consultation is presented. The patient, a 70-year-old woman was being followed because of a tumor in the left buttock. Cytological smears were obtained after scrapping the tumoral cut surface and revealed a myxoid background with fragments composed of a denser, fibrillar metachromatic stroma with accompanying round to oval tumoral nuclei and no vessels. Single cells were predominantly monomorphic with a round to oval morphology and scarce cytoplasm. The most relevant feature of the tumor was its peripheral, plaque-like, calcified consistency. The review of the cytological descriptions of four cases revealed similar findings that can be presumed as those of a low-grade myxoid tumor of round to oval cells. A specific recognition of OFMT based solely on cytological features seems difficult. However, when such features are coupled with characteristic radiological findings (peripheral calcification) this entity must be considered.

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Ossifying Fibromyxoid Tumor Misdiagnosed as Follicular Neoplasia

Cited by 14 publications

References 6 publications

Cytologic diagnosis of ossifying fibromyxoid tumor of soft tissue: A case report

Cytologic diagnosis of ossifying fibromyxoid tumor of soft tissue: A case report

Fine Needle Aspiration Cytology of the Malignant Variant of Ossifying Fibromyxoid Tumor of Soft Parts

Cytological features of ossifying fibromyxoid tumor of soft parts

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