Ossifying Fibromyxoid Tumor of the Retromolar Trigone: A Case Report and Systematic Review of the Literature

Abstract

Ossifying fibromyxoid tumor (OFMT) is a mesenchymal neoplasm of uncertain lineage and intermediate biologic behavior. Involvement of the head and neck area is infrequent (10% to 15%) and intraoral presentation is very rare. An OFMT developing in the retromolar trigone of a 13-year-old male is presented, along with a comprehensive review of oral OFMT cases. Among 12 oral OFMTs (including the present case), most patients were male (72.7%), with a mean age of 30.3 (13-67) years. The tumors generally appeared as painless masses of firm or hard consistency (mean diameter 27.7 mm), most commonly located in the soft tissues of the mandible (50%). Common microscopic features included ossification, lack of atypia or high mitotic activity, and immunohistochemical positivity for S100 (5/7), vimentin (6/6), GFAP (3/6), and SMA (2/6). Recurrence was reported only in one case. Further characterization of this rare entity is needed to increase our understanding of its distinct clinical and histopathologic features.

Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up

“…The real incidence of this lesion in the mouth may be underestimated, since proper diagnosis is difficult, considering the clinical, microscopical, and immunohistochemical features overlapping with several other lesions. 9,13 to 67 8 years), with a male: female ratio of 1.5:1. The most common clinical presentation was a painless nodule covered by normal mucosa and smooth surface.…”

Ossifying fibromyxoid tumor in the lower extremity mimicking a sebaceous cyst. Case report and literature review

“…In terms of site, OFMT is common in the extremities [ 1 ], although it has also been reported in the soft parts of the head and neck [ 8 , 9 ]. As for presentation, OFMT presents as an asymptomatic slow growing deeply-seated mass attached to the surrounding structures such as fascia or skeletal muscles [ 7 ].…”

A rare case report of a typical variant ossifying fibromyxoid tumor (OFMT), located in the retroauricular perimastoid region

“…Involvement of the head and neck area is infrequent (10% to 15%) and intraoral presentation is very rare [ 10 , 11 ]. Nevertheless, tumor locations such as the oral cavity, mandibular gingival, tongue, etmoid sinus and other sites of the head and neck region have been described in the literature [ 11 ].…”