Ossifying fibromyxoid tumour of soft parts: report of a case diagnosed on fine needle aspiration cytology

Gupta, Srishti; Gupta, Ruchika; Singh, Sompal; Pant, Leela

doi:10.1111/j.1365-2303.2010.00844.x

Cited by 13 publications

(22 citation statements)

References 10 publications

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“…Tumor cells were small with eccentrically located nuclei and inconspicuous nucleoli. As in Gupta et al report, we also observed nuclear grooves in few cells.…”

Section: Discussionsupporting

confidence: 90%

Fine‐needle aspiration features of ossifying fibromyxoid tumor in the breast: A case report and literature review

Gajdzis

Laé

Choussy

et al. 2019

Diagnostic Cytopathology

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Ossifying fibromyxoid tumor (OFT) is a very rare soft tissue tumor which is characterized by incomplete peripheral mature bone shell. To date, cytological features of OFT have been poorly studied with only seven case reports. In this study, an additional case of OFT investigated by fine‐needle aspiration is presented. A 75‐year‐old man with advanced nasopharyngeal carcinoma presented with peripherally calcified right breast mass. Smears were hypercellular and stroma‐rich. Tumor cells were mainly dispersed, with epithelioid morphology and eccentrically located nuclei. In the background, there was abundant eosinophilic myxoid secretion. No necrosis, atypia, or mitotic activity was found. The tumor showed diffuse S‐100, CD10, STAT6 expression and focal desmin, estrogen receptor (ER), and progesteron receptor (PgR) expression. Fluorescence in situ hybridization study revealed PHF1 rearrangement in 9% of cells. Cytological characteristic of OFT is quite distinctive and precise diagnosis can be made, especially when it is coupled with compatible radiological findings.

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“…Tumor cells were small with eccentrically located nuclei and inconspicuous nucleoli. As in Gupta et al report, we also observed nuclear grooves in few cells.…”

Section: Discussionsupporting

confidence: 90%

Fine‐needle aspiration features of ossifying fibromyxoid tumor in the breast: A case report and literature review

Gajdzis

Laé

Choussy

et al. 2019

Diagnostic Cytopathology

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“…In the case reported by Lax and Langsteger[6] concerning a case of OFMT located in the neck, round cell morphology was so remarkable as to induce confusion with a follicular thyroid neoplasm. This report and further ones[689] also describe a peculiar pseudoacinar arrangement of tumoral cells not present in our case. There is evidence to believe in the existence of a malignant variant of OFMT.…”

Section: Discussionsupporting

confidence: 84%

“…[3–5] Cytological features of four cases have been reported. [6–9] We present a further case evaluated during an intraoperative consultation. It is our experience that cytological findings coupled with characteristic peripheral ossification seen on image studies or macroscopically may lead to suspect this peculiar neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Cytological features of ossifying fibromyxoid tumor of soft parts

Álvarez-Rodríguez¹,

Ja²,

Salas³

et al. 2012

J Cytol

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A case of ossifying fibromyxoid tumor (OFMT) evaluated during an intraoperative pathological consultation is presented. The patient, a 70-year-old woman was being followed because of a tumor in the left buttock. Cytological smears were obtained after scrapping the tumoral cut surface and revealed a myxoid background with fragments composed of a denser, fibrillar metachromatic stroma with accompanying round to oval tumoral nuclei and no vessels. Single cells were predominantly monomorphic with a round to oval morphology and scarce cytoplasm. The most relevant feature of the tumor was its peripheral, plaque-like, calcified consistency. The review of the cytological descriptions of four cases revealed similar findings that can be presumed as those of a low-grade myxoid tumor of round to oval cells. A specific recognition of OFMT based solely on cytological features seems difficult. However, when such features are coupled with characteristic radiological findings (peripheral calcification) this entity must be considered.

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“…The majority of cases behave in a clinically benign fashion, however; a small percentage of tumors may locally recur or metastasize. [18][19][20][21][22][23] We describe a case of ossifying fibromyxoid tumor and review the cytomorphologic features of these tumors. 15 Recently, molecular studies have been able to demonstrate PHF1 gene (6p21) rearrangement in a significant number of OFMT cases.…”

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confidence: 99%

Ossifying fibromyxoid tumor: Report of a case with cytomorphologic description

Ahmed

Qasem

Salih

2015

Diagnostic Cytopathology

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Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm with uncertain histogenesis. Most cases behave in a clinically benign fashion; however, a small percentage of tumors may locally recur or metastasize. Herein we present a case of a 56-year-old man who presented with an enlarging left groin mass, left inner thigh numbness, burning paresthesia and discomfort in his left groin. The mass sampled by fine- needle aspiration and needle core biopsy. Cytology showed bland-appearing epithelioid cells with round nuclei and fine chromatin, with fragments of fibromyxoid stroma in the background. Immunohistochemical stains performed on the core biopsy showed that the lesional cells were focally positive for S100 protein and negative for desmin, smooth muscle actin, CD34 and cytokeratin AE1/AE3. A benign neoplasm was favored with ossifying fibromyxoid tumor as the main entity in the differential diagnosis. A subsequent resection showed a well-circumscribed 5 cm mass with firm consistency and focal areas of calcifications. Histologically, the tumor had a nodular growth pattern with relatively bland spindle cells containing round to oval nuclei suspended in a variably collagenous to myxoid stroma. Significant ossification and bone formation was also noted. There was no significant atypia, necrosis or increased mitoses. Ossifying fibromyxoid tumors have distinct cytologic features and should be considered in the differential diagnosis of soft tissue tumors with prominent ossification.

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Ossifying fibromyxoid tumour of soft parts: report of a case diagnosed on fine needle aspiration cytology

Cited by 13 publications

References 10 publications

Fine‐needle aspiration features of ossifying fibromyxoid tumor in the breast: A case report and literature review

Fine‐needle aspiration features of ossifying fibromyxoid tumor in the breast: A case report and literature review

Cytological features of ossifying fibromyxoid tumor of soft parts

Ossifying fibromyxoid tumor: Report of a case with cytomorphologic description

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