Ossifying Parotid Carcinoma ex Pleomorphic Adenoma

Abstract

We present a unique case of an extensively ossified carcinoma ex pleomorphic adenoma (CXPA) in a 76-year-old man with a five-year history of a slowly growing parotid mass. Fine-needle aspiration of the mass was nondiagnostic. A computed tomography (CT) scan of the lesion revealed a well-circumscribed mass with peripheral calcification. Initial pathological analysis suggested a benign parotid mass, but rigorous decalcification revealed noninvasive CXPA. The patient underwent complete resection of the mass and remained disease-free nine months later. Extensive ossification of a seemingly benign parotid mass may mask areas of carcinoma that may progress if left untreated.

A Rare Case of Multiple Calcifications and Vascular Malformation Within the Parenchyma of the Parotid Salivary Gland Coinciding With an Intracranial Meningioma

“…The importance of clinical suspicion for a malignancy in the presence of a calcified mass has been highlighted in literature. [39] The above mentioned referrals were absolutely essential in the present as a biopsy was not recommended for this case due to the vascular malformation that was evident within the lesion. It should be noted that Salivary gland tumors rarely show calcifications in the parenchymal tissue; however, it is commonly seen in inflammatory disorders of salivary glands.…”

PTEN e p53 no adenoma pleomórfico e no carcinoma ex-adenoma pleomórfico: expressão imuno-histoquímica

“…O diagnóstico diferencial dos tumores calcificados da parótida ou parafaríngea é amplo e inclui adenoma pleomórfico, condroma ou osteoma de tecidos moles, meningioma extracraniano, por esse motivo exames de imagem podem ser utilizados tanto para contribuir para o diagnóstico do adenoma pleomórfico quanto para determinar as dimensões da cirurgia de ressecção desses casos. (26,27) A opção mais indicada é a ressonância magnética, uma técnica que apresenta alta definição dos tecidos moles, tornando possível a diferenciação entre glândula salivar, lesão e tecidos adjacentes (28,29).…”