OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia

Kang, HyunJun; Hoang, Dinh Hoa; Valerio, Melissa; Pathak, Khyatiben; Zhang, Lianjun; Buettner, Ralf; Chen, Fang; Estrella, Katrina; Graff, William; Li, Zhuo; Xie, Jun; Horne, David; Kuo, Ya-Huei; Zhang, Bin; Pirrotte, Patrick; Nguyen, Le Xuan Truong; Marcucci, Guido

doi:10.1038/s41375-024-02146-5

Leukemia

2024

DOI: 10.1038/s41375-024-02146-5

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OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia

HyunJun Kang,

Dinh Hoa Hoang,

Melissa Valerio

et al.

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SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36

Yang,

Li,

Sears

et al. 2024

Front. RNA Res.

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Ribosome biogenesis is essential for cell growth, proliferation, and animal development. Its deregulation leads to various human disorders such as ribosomopathies and cancer. Thus, tight regulation of ribosome biogenesis is crucial for normal cell homeostasis. Emerging evidence suggests that posttranslational modifications such as ubiquitination and SUMOylation play a crucial role in regulating ribosome biogenesis. Our recent studies reveal that USP36, a nucleolar deubiquitinating enzyme (DUB), acts also as a SUMO ligase to regulate nucleolar protein group SUMOylation, thereby being essential for ribosome biogenesis. Here, we provide an overview of the current understanding of the SUMOylation regulation of ribosome biogenesis and discuss the role of USP36 in nucleolar SUMOylation.

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SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36

Yang,

Li,

Sears

et al. 2024

Front. RNA Res.

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OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia

Cited by 1 publication

References 14 publications

SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36

SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36

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