Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model

Roch, Paul Jonathan; Henkies, Danny; Carstens, Jan; Krischek, Carsten; Lehmann, Wolfgang; Komrakova, Marina; Sehmisch, Stephan

doi:10.3389/fendo.2020.556581

Cited by 18 publications

(19 citation statements)

References 66 publications

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“…The capillary ratio was only marginally affected by OST or RAL administration in both experiments. In contrast, a previous study that examined OST therapeutic administration in ovariectomized rats showed an increase of the capillary ratio in skeletal muscles [ 15 ] that could be explained by enhanced sensitivity of female muscle to OST compared to male muscle. Similar to our results, RAL, and estrogen did not change the capillary ratio in the skeletal muscles of the ovariectomized rats [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 59%

“…In line with this would be the reduced CSA that was observed in the RAL and OST + RAL groups, while the RAL group showed decreased food intake in the present experiment. Considering the fact that another SARM enhanced intramuscular fat content [ 15 ], the reduction in muscle weight under combined treatment, along with a decrease in CSA, which indirectly indicates the size of the abdominal fat depot [ 44 ], could be considered a positive effect of OST + RAL treatment on orchiectomized rat physiology.…”

Section: Discussionmentioning

confidence: 99%

“…1 ): Group 1, Non-ORX ( n = 15); Group 2, ORX ( n = 15), and Groups 3 to 5, ORX rats treated with OST, RAL, or a combination of both (RAL + OST), with a dosage of 0.4 mg/kg BW for OST and 7 mg/kg BW for RAL immediately after ORX (prophylactically) [OST-P ( n = 15), RAL-P ( n = 15), and OST + RAL-P ( n = 15)] for up to 18 weeks. The dosages of the substances were chosen based on our previous studies [ 15 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the activity of alkaline phosphatase (ALP) and CK, concentration of calcium (Ca), magnesium (Mg), and phosphorus (P) in serum, an automated chemistry analyzer Architect c16000 (Abbott, Wiesbaden, Germany) and commercially available kits (Abbott) were used at the Department of Clinical Chemistry, University of Goettingen, according to the manufacturer’s instructions (Abbott). The following methods were applied: ALP: paranitrolphenyl phosphate method (7D55-30, Abbott) (serum total ALP was determined according to the strong correlation to bone-specific ALP [ 36 ]); Ca and Mg: quantification by arsenazi III dye (7D61-20 and 7D70-30, Abbott); P: ammonium molybdate method (7D71-30, Abbott); CK: reactivator method with N -acetyl- L -cysteine (7D63-30, Abbott) [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Ostarine (OST), also labeled as enobosarm, S-22, MK-2866, or GTx-024, is a SARM that has been clinically shown to have beneficial effects on body mass, muscles, and physical function [ 12 – 14 ]. In a postmenopausal rat model, OST increased vascularization and the activity of citrate synthase in skeletal muscles [ 15 ]. Raloxifene (RAL) is a SERM that treatment with which is associated with increased serum levels of testosterone and estrogen in elderly men [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Combination of selective androgen and estrogen receptor modulators in orchiectomized rats

Roch

Wolgast

Gebhardt

et al. 2022

J Endocrinol Invest

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Purpose Selective androgen and estrogen receptor modulators, ostarine (OST) and raloxifen (RAL), reportedly improve muscle tissue and offer therapeutic approaches to muscle maintenance in the elderly. The present study evaluated the effects of OST and RAL and their combination on musculoskeletal tissue in orchiectomized rats. Methods Eight-month-old Sprague Dawley rats were analyzed. Experiment I: (1) Untreated non-orchiectomized rats (Non-ORX), (2) untreated orchiectomized rats (ORX), (3) ORX rats treated with OST during weeks 0–18 (OST-P), (4) ORX rats treated with OST during weeks 12–18 (OST-T). Experiment II: 1) Non-ORX, (2) ORX, 3) OST-P, (4) ORX rats treated with RAL, during weeks 0–18 (RAL-P), 5) ORX rats treated with OST + RAL, weeks 0–18 (OST + RAL-P). The average daily doses of OST and RAL were 0.4 and 7 mg/kg body weight (BW). Weight, fiber size, and capillarization of muscles, gene expression, serum markers and the lumbar vertebral body were analyzed. Results OST-P exerted favorable effects on muscle weight, expression of myostatin and insulin growth factor-1, but increased prostate weight. OST-T partially improved muscle parameters, showing less effect on the prostate. RAL-P did not show anabolic effects on muscles but improved body constitution by reducing abdominal area, food intake, and BW. OST + RAL-P had an anabolic impact on muscle, reduced androgenic effect on the prostate, and normalized food intake. OST and RAL improved osteoporotic bone. Conclusions The OST + RAL treatment appeared to be a promising option in the treatment of androgen-deficient conditions and showed fewer side effects than the respective single treatments.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Combination of selective androgen and estrogen receptor modulators in orchiectomized rats

Roch

Wolgast

Gebhardt

et al. 2022

J Endocrinol Invest

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Ostarine blunts the effect of endurance training on submaximal endurance in rats

Vasilev,

Boyadjiev,

Hrischev

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (n = 10 each, in total n = 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics.

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Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis

Hoffmann,

Derout,

Müller-Reiter

et al. 2023

J Bone Miner Metab

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Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model

Cited by 18 publications

References 66 publications

Combination of selective androgen and estrogen receptor modulators in orchiectomized rats

Combination of selective androgen and estrogen receptor modulators in orchiectomized rats

Ostarine blunts the effect of endurance training on submaximal endurance in rats

Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis

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