Osteo-Anabolic Effects of Human Growth Hormone with 22K- and 20K Daltons on Human Osteoblast-Like Cells.

Wang, Da-Shen; Sato, Kanji; Demura, Hiroshi; Kato, Yoshiharu; Maruo, Naoko; Miyachi, Yukitaka

doi:10.1507/endocrj.46.125

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…BMP‐7, which has not previously been examined, was elevated in only one population of PLC, although a second population appeared to respond but with high variance. ALP expression was up‐regulated (consistent with other reports in human osteoblast‐like cells in vitro ) (20, 23, 24) whereas BSP mRNA was down‐regulated in the majority of the cell populations.…”

Section: Discussionsupporting

confidence: 89%

Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone‐derived cells

Haase¹,

Ivanovski²,

Waters

et al. 2003

J of Periodontal Research

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Section: Discussionsupporting

confidence: 89%

Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone‐derived cells

Haase¹,

Ivanovski²,

Waters

et al. 2003

J of Periodontal Research

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“…Body weights and serum IGF-I increased dosedependently in both 20K-GH and 22K-GH treated groups [6]. Study on the osteo-anabolic effect of GH in cultured human osteoblastlike cells revealed that both 20K-GH and 22K-GH stimulated bone remodeling and exhibit equipotent anabolic effects on skeletal tissues [7]. 20K-GH also exhibited potent lipolytic effects comparable to 22K-GH in an in-vitro experiment model [8].…”

Section: Biological Effectmentioning

confidence: 98%

20K-GH and its use in detecting GH abuse

Irie

Ueki

Kishikawa

et al. 2009

Growth Hormone & IGF Research

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“…In addition, the lactogenic activity is also lower than that for 22K-hGH (7). Recombinant 20K-hGH has been shown to stimulate linear growth in spontaneous dwarf rats (8), to induce lipolysis in 3T3L-1 cells expressing hGHR (9), and to have an osteoanabolic effect in human osteoblast cells (10), all of which were comparable to the effects of 22K-hGH.…”

mentioning

confidence: 98%

Metabolic Effects of 20-Kilodalton Human Growth Hormone (20K-hGH) for Adults with Growth Hormone Deficiency: Results of an Exploratory Uncontrolled Multicenter Clinical Trial of 20K-hGH

Hayakawa¹,

Shimazaki²,

Tsushima

et al. 2004

The Journal of Clinical Endocrinology & Metabolism

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The biological effects of 20-kDa human GH (20K-hGH), which is produced in the pituitary by alternative splicing of GH mRNA and comprises approximately 6% of all GH in serum, have not been reported. We have investigated the metabolic effects of recombinant 20K-hGH in adult patients with GH deficiency in an exploratory study. Three doses of 20K-hGH (0.006, 0.012, and 0.024 mg/kg.d), were administered for 16 wk to three groups (consisting of 18 or 19 subjects), respectively. The 20K-hGH dose-dependently increased serum IGF-I and IGFBP-3 levels, and the lowest dose (0.006 mg/kg) was enough to normalize both hormones by wk 4. Serum osteocalcin levels and urinary deoxypyridinoline excretion were also dose-dependently increased. There was a significant decrease in body fat mass with an increase of lean body mass at the lowest dose of 0.006 mg/kg.d. Blood glucose and serum insulin were increased significantly at 4 wk only in the high-dose group (0.024 mg/kg). Glucose tolerance was slightly impaired in 26-39% of patients in all treatment groups as judged by oral glucose tolerance tests, but there was no development of overt diabetes. The major adverse event in the 20K-hGH treatment was peripheral edema, similar to the incidence reported for 22K-hGH. The data demonstrated that 20K-hGH had metabolic effects comparable to those of 22K-hGH in humans. The results suggest that 20K-hGH could be used to treat GH-deficient patients, although further studies may be required to investigate the optimum dose and superiority of 20K-hGH over 22K-hGH in a comparative study.

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Osteo-Anabolic Effects of Human Growth Hormone with 22K- and 20K Daltons on Human Osteoblast-Like Cells.

Cited by 8 publications

References 34 publications

Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone‐derived cells

Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone‐derived cells

20K-GH and its use in detecting GH abuse

Metabolic Effects of 20-Kilodalton Human Growth Hormone (20K-hGH) for Adults with Growth Hormone Deficiency: Results of an Exploratory Uncontrolled Multicenter Clinical Trial of 20K-hGH

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