Osteoarthritis and all-cause mortality in worldwide populations: grading the evidence from a meta-analysis

Xing, Dan; Xu, Yin; Liu, Qiang; Ke, Yan; Wang, Bin; Li, Zhichang; Lin, Jianhao

doi:10.1038/srep24393

Cited by 99 publications

(78 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with other studies, we found no increase in mortality risk in patients with knee or hip OA, although this was not the primary outcome for our study 34,35 .…”

Section: Discussionsupporting

confidence: 91%

The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study

Kendzerska

Jüni

King

et al. 2017

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…Consistent with other studies, we found no increase in mortality risk in patients with knee or hip OA, although this was not the primary outcome for our study 34,35 .…”

Section: Discussionsupporting

confidence: 91%

The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study

Kendzerska

Jüni

King

et al. 2017

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…A 2008 review suggested modest associations of OA with all-cause mortality but noted that technical shortcomings limited their conclusions, including differing study populations, small sample size and lack of inclusion of important covariates from some of the studies 12 . A more recent meta-analysis of nine studies reported no significant association between radiographic osteoarthritis (rOA) or symptomatic OA (SxOA) with mortality, however this study also did not differentiate between joint sites affected by OA, combining estimates for hand, knee, hip and spine OA 13 . Prospective studies addressing knee OA specifically as a risk factor for premature mortality have been equivocal with some reporting lower mortality among those with knee OA 14e16 and others reporting higher mortality rates 17e19 .…”

Section: Introductionmentioning

confidence: 73%

The impact of painful knee osteoarthritis on mortality: a community-based cohort study with over 24 years of follow-up

Cleveland

Álvarez

Schwartz

et al. 2019

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

s u m m a r yObjective: To investigate the impact of knee osteoarthritis (OA) and/or knee pain on excess mortality. Method: We analyzed data from 4,182 participants in a community-based prospective cohort study of African American and Caucasian men and women aged 45 years. Participants completed knee radiographs and questionnaires at baseline and at up to three follow-ups to determine knee OA (rOA), knee pain and covariate status. Mortality was determined through 2015. We used Cox proportional hazards regression with time-varying covariates (TVC) to estimate hazard ratios (HR) and 95% confidence intervals (CI). Additional analyses stratified by sex, race and age were carried out. Results: Median follow-up time was 14.6 years during which 1822 deaths occurred. Baseline knee radiographic osteoarthritis (rOA) was 27.7%, 38.8% at first follow-up, 52.6% at second follow-up and 61.9% at the third follow-up. Knee rOA with pain and knee pain alone were both associated with a >15% increase in premature all-cause mortality. In analyses stratified by sex, race and age, associations between knee pain, with or without knee rOA, and all-cause death were found among women, Caucasians, those 65 years of age, and those with a body mass index (BMI)30, with observed increased risks of death between 21% and 65%. We observed similar, somewhat attenuated, results for cardiovascular disease (CVD) deaths. Conclusion: In models taking into account variables that change over time, individuals who had knee pain, alone or with knee rOA, had increased mortality. These effects were particularly strong among those obese. Effective interventions to reduce knee pain, particularly those including weight management and prevention of comorbidities, could reduce mortality.

show abstract

“…Several studies have also assessed the relation of knee OA to the risk of mortality 4–9 . Although findings are inconclusive, a few recently published studies have reported that knee symptomatic OA (SxOA) was associated with a high risk of all-cause mortality 4–6 .…”

Section: Introductionmentioning

confidence: 99%

Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study

Liu

Niu

et al. 2017

Sci Rep

Self Cite

View full text Add to dashboard Cite

Knee symptomatic osteoarthritis (SxOA) was associated with all-cause mortality. Walking disability and NSAIDs use have been postulated as potential mechanisms linking knee SxOA to all-cause mortality. Data were collected on ability of walking for 1 kilometer and use of NSAIDs at baseline and death information at follow-up. Subjects with knee SxOA were identified if at least one knee had both radiographic OA and pain. We first fitted a Cox proportional hazards model to examine the relation of knee SxOA to the risk of all-cause mortality. We then used marginal structural models to decompose total effect of knee SxOA on all-cause mortality into indirect and direct effects via walking disability and use of NSAIDs, respectively. Among 1025 subjects, 99 died over 8 years of follow-up. A multivariable adjusted hazard ratio of mortality for SxOA was 1.98 (95% CI: 1.09–3.62). The indirect effect of knee SxOA on all-cause mortality through either a walking disability or NSAIDs use was 1.92 (95% CI: 0.86–4.26) and 1.45 (95% CI: 0.72–2.92), respectively. The corresponding direct effect was 1.08 (95% CI: 0.55–1.12) and 1.35 (95% CI: 0.75–2.44). In this population-based cohort study, high all-cause mortality from knee SxOA was mediated mainly through a walking disability.

show abstract

Osteoarthritis and all-cause mortality in worldwide populations: grading the evidence from a meta-analysis

Cited by 99 publications

References 24 publications

The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study

The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study

The impact of painful knee osteoarthritis on mortality: a community-based cohort study with over 24 years of follow-up

Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study

Contact Info

Product

Resources

About