Osteoarthritis and internal derangemen of the temporomandibular joint: A light microscopic study

Bont, Lambert G.M. de; Boering, G; Liem, Rsb; Eulderink, F; Westesson, Per‐Lennart

doi:10.1016/s0278-2391(86)80075-1

Cited by 198 publications

(65 citation statements)

References 22 publications

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“…The number of condylar erosions in our controls may be overestimated, since they were patients recruited from rheumatologists' offices or physiotherapy clinics with mechanical joint disease or osteoarthritis, conditions which could lead to flattening of the condylar head. 32 The interrater reliability was only fair for the number of molars with PLS widening (ICC = 0.25), increasing the chance of misclassification for results pertaining to this measurement. The correlation between disease severity, erosions, and PLS widening and the impact on quality of life will be addressed in future reports.…”

Section: Discussionmentioning

confidence: 96%

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

Dagenais

MacDonald

Baron

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective-The aim of this study was to compare oral radiologic abnormalities associated with systemic sclerosis (SSc) against abnormalities in the general population.Study Design-Patients with SSc and healthy controls were enrolled in a multi-site crosssectional study. Included in the radiology examination were a panoramic radiograph, four bitewings, and an anterior mandibular periapical radiograph. Radiographs were evaluated by two oral and maxillofacial radiologists tested for interobserver and intraobserver reliability. Chisquared tests, Fisher exact tests, and Mann Whitney U tests were used to summarize the radiologic manifestations of patients and controls.Results-We assessed 163 SSc patients and 231 controls. Widening of the periodontal ligament space (PLS) (P < .001), with higher percentage of teeth with PLS widening (P < .001), was significantly more frequent in patients with SSc than in controls. The most significant differences between the two groups were found in the molars and premolars (P < .001). Moreover, 26% of the patients with SSc had a periapical PLS greater than 0.19 mm compared with 13% of the controls (P = .003). Patients with SSc had significantly more erosions compared with controls (14.5% vs. 3.6%; P < .001), mostly in the condyles (P = .022), coronoid processes (P = .005) and other locations (P = .012). CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptConclusion-Patients with SSc had more teeth with PLS widening and erosions of the mandible compared with controls.Systemic sclerosis (SSc) is a multi-system disorder of connective tissue characterized clinically by thickening and fibrosis of the skin and involvement of internal organs. Prevalence estimates for SSc are between 240 per million 1 and 276 per million 2 in an American population. The incidence rate of SSc is about 20 new cases per million per year. 3 It affects mainly women in their third or fourth decade of life and is associated with significant morbidity and increased mortality. No treatment has been shown to alter the natural history of SSc. 4 SSc is characterized by fibroblast dysfunction, which leads to fibrosis of the skin, internal organs, or both; 5 autoantibodies (anticentromere, antitopoisomerase I, anti-RNA polymerase III); and vasculopathy. 5,6 SSc is usually categorized into limited cutaneous SSc (lcSSc), diffuse cutaneous SSc (dcSSc), and SSc without skin involvement. 6 Although several candidate genes and regions of the genome have been identified as potentially being involved in SSc, these are also associated with other autoimmune conditions. SSc is a complex disease, where no single polymorphism is known to cause the complete manifestation of the condition; it has been suggested that it may be the combined action of several single nucleotide polymorphisms in different genes that may result in the complex traits of the disease. 7 We compared patients with SSc with a control population and demonstrated that oral problems in patients with SSc include decreased oral opening, decreased s...

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Section: Discussionmentioning

confidence: 96%

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

Dagenais

MacDonald

Baron

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Irreversible changes in the TMJ structure, especially transformation and displacement of the TMJ disc and destructive changes in the condyle and fossa, disrupt normal jaw movement (internal derangement) [3,27,30]. Although the pathogenesis for TMJ diseases is not fully understood, it is assumed that irreversible elongation with loosening of the posterior attachment is a critical phenomenon in TMJ diseases [3,27,30].…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathogenesis for TMJ diseases is not fully understood, it is assumed that irreversible elongation with loosening of the posterior attachment is a critical phenomenon in TMJ diseases [3,27,30]. Gage et al [4] suggested that a higher ratio of type III collagen in the posterior attachment increases tissue fragility and results in displacement of the TMJ disc.…”

Section: Discussionmentioning

confidence: 99%

An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Hamaya

Takahashi

Sasano

et al. 2001

Acta Histochem. Cytochem

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We sought to immunohistochemically localize types I, II and III collagen in various regions of the temporomandibular joint (TMJ) in two female rhesus monkeys at different growth stages: juvenile and late-adolescence. In the condylar cartilage, staining for types I and III collagen was weak in the fibrous layer, intense in the pre-cartilaginous layer, and faint in the cartilaginous layer, whereas that for type II collagen was limited to the cartilaginous layer. The glenoid fossa showed moderate staining for type I collagen and weak staining for type II collagen, indicating that this tissue consists of chondroid bone, which is an intermediary between bone and cartilage. TMJ discs showed more intense staining for types I and III collagen in their periphery than in their centers. Staining for type II collagen was not detected throughout the disc. The posterior attachments showed rather weak staining for type I collagen and relatively intense staining for type III collagen. These results suggest that there are regional differences in the phenotypic expression of the three major collagen components in the growing monkey TMJ, which probably provide specific biomechanical resistance.

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“…After that follows a phase in which TMJ presents at first with deep surface cracks and then with progressive loss of the cartilage due to mechanical abrasion . In this phase proliferated condrocytes can be observed next to the deeper cracks of the cartilage (de Bont , Boering et al, 1986). At a final stage, cracks in the cartilage appear more and more deep and the cartilage gradually disappears as a consequence of total destruction of collagene and proteoglycans.…”

Section: Initiation Of Tmj Oamentioning

confidence: 93%

“…The loose disc does not stay in its normal position but falls, usually anteriorly, starting the process of disc displacement (Nitzan, 2001) When the retrodiscal area is inadaptable, it perforates on loading, thus leading to arthritis. Conversely, it has been suggested that TMJ arthritis may precede disc displacement (de Bont , Boering et al, 1986) Joint degeneration is associated with disintegration of the joint constituents. Many studies have shown arthritis changes prior to disc displacement.…”

Section: Initiation Of Tmj Oamentioning

confidence: 99%

Low Level Laser Therapy in the Treatment of Temporomandibular Joint Arthritis: Questions and Answers

Marini¹,

Rosaria²

2012

Osteoarthritis - Diagnosis, Treatment and Surgery

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Osteoarthritis and internal derangemen of the temporomandibular joint: A light microscopic study

Cited by 198 publications

References 22 publications

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Low Level Laser Therapy in the Treatment of Temporomandibular Joint Arthritis: Questions and Answers

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