Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3)

Jinks, Clare; Jordan, Kelvin; Croft, Peter

doi:10.1093/rheumatology/kem013

Cited by 153 publications

(103 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of this study support previous literature demonstrating the broader impact of OA on individual's lives [14][15][16]. Notably, our study highlights that the impact of OA is not limited to the individual but also stretches to their family/carers.…”

Section: Discussionsupporting

confidence: 89%

Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey

et al. 2014

View full text Add to dashboard Cite

Osteoarthritis (OA) is the fastest growing cause of disability worldwide. The aim of this study was to understand the impact of OA on individuals and to explore current treatment strategies. An online UK-wide survey of people with self-reported OA was conducted composed of 52 questions exploring the impact of OA, diagnosis and treatment, the role of health professionals and self-management. 4,043 people were invited with 2,001 respondents (49% response, 56% women, mean age 65 years). 52% reported that OA had a large impact on their lives. 15% of respondents had taken early retirement, on average 7.8 years earlier than planned. In consultations with general practitioners, only half reported a discussion on pain; fewer reported discussing their fears (21%) or management goals (15%).Nearly half (48%) reported not seeking medical help until pain was frequently unbearable.Oral analgesics (62%), topical therapies (47%), physiotherapy (38%) and steroid injections (28%) were commonly used. The majority (71%) reported varying degrees of persistent pain despite taking all prescribed medication. Although 64% knew that increasing exercise was important, only 36% acted on this knowledge; 87% who increased exercise found it beneficial. Over half had future concerns related to mobility (60%), maintaining independence (52%) and coping with everyday activities (51%). OA had significant individual economic impact especially on employment. Current treatment strategies still leave most people in pain with significant fears for the future. There is considerable opportunity to improve the holistic nature of OA consultations especially in provision of information and promotion of self-management strategies.

show abstract

Section: Discussionsupporting

confidence: 89%

Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey

et al. 2014

View full text Add to dashboard Cite

show abstract

“…6,7 The main problem with OA of the knee, and the biggest factor in the disability of patients, is pain. 8,9 Pain renders patients inactive, and decreased joint movement disturbs the repair capacity of the articular cartilage. Moreover, inactivity weakens the lower extremity muscles, and this accelerates the progression of OA.…”

Section: Introductionmentioning

confidence: 99%

Clinical Validation of Pain Management Manipulative Therapy for Knee Osteoarthritis With the Squeeze-Hold Technique: A Case Series

Nakajima

2017

Journal of Chiropractic Medicine

View full text Add to dashboard Cite

Objective: The purpose of this case series was to describe the short-term and long-term clinical effects of a manual technique for treating osteoarthritis (OA) knee pain. Methods: This study measured of the immediate effect and long-term effect by using a case series of different groups of subjects. Knee OA and activity restriction in patients were evaluated by using the Kellgren-Lawrence (K/L) Grading Scale and the Japanese Knee Osteoarthritis Measure (JKOM) index. In the intervention, lower limb muscles were squeezed by hand for 20 seconds. Each squeeze was performed for both lower limbs. Passive range-of-motion (ROM) exercise was performed on the knee joint. In one set of cases, immediate effects were measured after a one-time treatment with pretreatment and posttreatment outcome measures. Eleven people with knee OA participated in the study. On a visual analogue scale (VAS) for pain, muscle stiffness, and muscular hemodynamics for estimation of muscle blood flow were recorded before and after the squeeze-hold treatment. In another set of cases, the treatment was given to all patients once a week for 6 months, and long-term effects were measured. Data on 5 subjects with knee OA were collected for 6 months after initial treatment. The VAS for pain and JKOM were recorded every month for 6 months. Results: For immediate effects, the VAS was 69 ± 21 mm before treatment and 26 ± 22 mm after treatment. Muscle stiffness was 8.8 ± 3.6 (absolute number) before treatment and 3.5 ± 2.1 after treatment. Tissue (muscle) oxygen saturation was 60.1 ± 5.7% before treatment and 65.3 ± 4.8% after treatment. Total hemoglobin was 24.3 ± 3.3 (absolute number) before treatment and 25 ± 2.3 after treatment. A tendency for reduction in OA knee pain and muscle stiffness was observed, and a tendency for increase was observed in the blood flow in the muscle. For long-term effects in all 5 participants (any K/L grade, any JKOM score), OA knee pain and JKOM score improved gradually through 6 months. Conclusions: The participants in this case series showed improvement in pain and function. These findings indicate the feasibility of a larger study on the squeeze-hold intervention for OA knee pain. (J Chiropr Med 2017;16:122-130)

show abstract

“…Osteoarthritis (OA), which develops due to the progressive destruction of articular cartilage, is the most common joint disease and the leading cause of pain and physical disability in elderly people (1,2). Moreover, as the proportion of elderly individuals in the population increases, the number of OA patients is expected to further increase.…”

Section: Introductionmentioning

confidence: 99%

Effect of a glucosamine-based combination supplement containing chondroitin sulfate and antioxidant micronutrients in subjects with symptomatic knee osteoarthritis: A pilot study

Nakasone¹,

Watabe²,

Watanabe³

et al. 2011

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. In the present study, we aimed to investigate the potential effect of a glucosamine (1,200 mg/day)-based dietary supplement combined with chondroitin sulfate and three antioxidant micronutrients, namely methylsulfonylmethane, guava leaf extract, and vitamin D (test supplement) on osteoarthritis (OA) of the knee. A 16-week, randomized, double-blinded, placebo-controlled trial was conducted involving 32 subjects with symptomatic knee OA. Clinical outcomes were measured using the Japanese Knee Osteoarthritis Measure (JKOM) for symptoms and a study diary-based visual analog scale (diary VAS) for pain at baseline and at weeks 4, 8, 12 and 16 during the 16-week intervention period. Furthermore, biomarkers for cartilage type II collagen degradation (C2C) and synovitis hyaluronan (HA) were measured. As compared with the baseline, the JKOM pain subscale was significantly improved at all of the four assessment time points in the test group, but was not at any time point in the placebo group. On the other hand, all of the four symptom subscales and the aggregated total symptoms were significantly improved in the two groups at one or more time points. However, all of these clinical improvements were greater in extent in the test group than in the placebo group, and there were significant differences between groups in the magnitude of changes from baseline for one subscale 'general activities' and the aggregated total symptoms at week 8 (P<0.05). The results of efficacy assessments with the diary VAS showed that all of the three pain subscales were significantly improved only in the test group at almost all the time points. Moreover, serum levels of C2C and HA were decreased by 10 and 25%, respectively, at week 16 in the test group, albeit not statistically significant, without any detectable changes in the placebo group. In conclusion, although the results obtained in this study were not conclusive, the tested glucosamine-based combination supplement is likely to have a beneficial effect on pain and other symptoms associated with knee OA.

show abstract

Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3)

Cited by 153 publications

References 24 publications

Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey

Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey

Clinical Validation of Pain Management Manipulative Therapy for Knee Osteoarthritis With the Squeeze-Hold Technique: A Case Series

Effect of a glucosamine-based combination supplement containing chondroitin sulfate and antioxidant micronutrients in subjects with symptomatic knee osteoarthritis: A pilot study

Contact Info

Product

Resources

About