Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Каратеев, А. Е.; Лила, А. М.

doi:10.14412/1995-4484-2018-70-81

Cited by 20 publications

(2 citation statements)

References 73 publications

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“…However, in recent years there has been a tendency to change the clinical concept of osteoarthritis. Many experts are inclined to the need for diagnostics of an early, radiological stage of OA, when adequate therapy can stop not only the progression but also achieve the reverse structural changes in the joint [6].…”

Section: Changes In Osteoprotegerin Inmentioning

confidence: 99%

Pathogenetic and diagnostic role of osteoprotegerin in the combined course of osteoarthritis and obesity

Litvynova

Pasiyeshvili

2022

J Educ Health Sport

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In recent years, it has been proven that the formation of OA can occur against the background of impaired bone metabolism. Bone remodeling is considered as a continuous complex process aimed at eliminating microdamages and updating the bone matrix. A key link in the regulation of this process is the system RANK / RANKL / OPG (osteoprotegerin), which provides a balance of activity of osteoblasts and osteoclasts. It blocks the interaction between RANK and RANKL by intercepting the RANKL ligand, which inhibits osteoclast development and reduces bone resorption. Thus, these properties of OPG can be considered as one of the pathogenetic factors in patients with dystrophic joint lesions. Objective: to investigate the content and role of osteoprotegerin in young patients with osteoarthritis, which occurs against the background of changes in body weight. Materials and methods. The study involved 75 young patients (mean age - 30.92 ± 0.546 years) with overweight or obesity, who in the previous stages of the study was diagnosed with osteoarthritis (main group). The comparison group was represented by 50 patients with osteoarthritis and normal body weight. The age of patients was 30.95 ± 0.545 years; as in the previous group, men predominated - 64% and 36% respectively. Benchmarks of osteoprotegerin were obtained in a study of 37 relatively healthy individuals of the same age and sex. The level of osteoprotegerin was determined by enzyme-linked immunosorbent assay using the FineTest EH0247 reagent kit, China. The outcomes were processed by the methods of variation statistics using the computer program STATISTICA.Results and discussion. When determining the content of OPG in the serum of patients of the main group was found to increase to 124.03 pg / ml, against control - 65.64 pg / ml. In the group of patients with isolated OA, this value was 92.29 pg / ml. Meaning that, in OA, running on the background of altered BMI, the content of OPG is likely to increase, both in relation to the norm and the results of the comparison group (p <0,001). The formation and course of osteoarthritis is accompanied by an increase in osteoprotegerin, the content of which depends on the degree of obesity and the radiological stage of the process. Conclusions: The course of osteoarthritis is accompanied by an increase in osteoprotegerin, which is considered a negative regulator of bone resorption. In osteoarthritis, which occurs against the background of changes in body mass index, a direct correlation with the degree of obesity. Changes in osteoprotegerin in patients with osteoarthritis depend on the radiological stage of joint damage and are most pronounced in individuals with stage 2 obesity and stage 2 radiological changes

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Section: Changes In Osteoprotegerin Inmentioning

confidence: 99%

Pathogenetic and diagnostic role of osteoprotegerin in the combined course of osteoarthritis and obesity

Litvynova

Pasiyeshvili

2022

J Educ Health Sport

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“…(ОА) -найбільш поширене захворювання суглобів, що супроводжується хронічним болем, різними ступенями функціонального обмеження, достатньо високим рівнем інвалідності, зниженням якості життя в США [1] та інших розвинених країнах [2,3]. На остеоартроз колінного суглоба припадає більш ніж 80 % загального тягаря хвороб [4]; це захворювання зустрічається у 3,8 % загальної популяції [5]; вражає не менш ніж 19 % дорослих американців віком 45 років і старіше [6].…”

Section: остеоартрозunclassified

Epidemiology of knee osteoarthritis

Kolesnichenko

Golka

Khanyk

et al. 2021

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

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Introduction. Osteoarthritis of the knee joint is a progressive incurable disease, which in the case of a severe course at a late stage leads to total joint replacement. Recently, experts have focused their attention to the prevention and treatment of early osteoarthritis, so it is important to understand the prevalence, frequency, and modified risk factors for knee OA. The aim is to investigate the patterns of morbidity and prevalence of osteoarthritis of the knee joint on the basis of scientific analysis of relevant modern literature. Materials and methods. Research material – scientific articles in the MEDLINE database for the period 2016–2020, reflecting the epidemiological indicators of osteoarthritis of the knee joint, and additional search for articles from bibliographic lists of selected literature sources. Research methods – a systematic review of relevant sources of literature. Results. Osteoarthritis of the knee joint is one of the most common diseases of the musculoskeletal system. The frequency of osteoarthritis steadily increases with age, overweight. The progressive nature of the disease, the presence of persistent pain lead to limited functionality and reduced efficiency; such patients in some cases require surgical treatment aimed at replacing the compromised joint, which requires significant economic costs, medical rehabilitation and social readaptation of patients and is a heavy burden for both the patient and society as a whole. The lack of correlation between clinical symptoms and radiological signs of osteoarthritis of the knee joint leads to low availability of orthopedic care: more than 30 % of patients with a first diagnosis have a pronounced stage of the disease, and in some cases the pathology is diagnosed only in connection with complications; the diagnosis of osteoarthritis due to the high percentage of painless development of the disease (40 %) is often established in the terminal stages. All this indicates the need for further research on various factors influencing the frequency, prevalence, economic and social burden of osteoarthritis of the knee. Conclusions. Osteoarthritis of the knee joint is characterized by high incidence, which increases with age, progressive course, limited functional capabilities. Treatment of such patients requires significant economic costs of society. A significant increase in the prevalence of osteoarthritis of the knee is associated with increased life expectancy, obesity and some other factors that require further research.

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Assessment of clinical significance of ultrasonographic detection ofhyperechogenic deposits in hyaline cartilage in patients with knee osteoarthritis

Петров

Matveeva

Petrov

2019

Naučno-praktičeskaâ revmatologiâ

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The aimof the study was to assess the relationship between the detection of hyperechogenic deposits (HD) in the hyaline cartilage of the knee joints (KJ) at ultrasonography in patients with osteoarthritis (OA), clinical manifestations and structural changes according to KJ ultrasonography and radiography.Material and methods.A prospective analysis of clinical, radiological and ultrasonographic data of 114 patients with knee OA was conducted. The patients were divided into two groups: 32 patients with HD detected in at least one of the KJ, and 82 patients without HD; 32 patients of the 1st group and 34 patients of the 2nd group were observed for 2 years. A comparative assessment of initial clinical manifestations (WOMAC index), x-ray data and ultrasonographic parameters of the subchondral bone, hyaline cartilage and the degree of synovial inflammation in the groups of patients at the beginning of the study and after 2 years was carried out. The exclusion criteria were other joint diseases; paroxysmal course of the inflammatory process in KJ; trauma and history of operations on KJ; ESR >20 mm/h, uric acid level >360 μmol/l and C-reactive protein >5 mg/l.Results and discussion.HD in hyaline cartilage was found in 28.1% of patients with knee OA. After 2 years HD remained in all patients having them at inclusion, and in 5.6% of the patients they were found for the first time. In 13 patients with HD in hyaline cartilage, synovial fluid was studied and in all cases calcium pyrophosphate crystals were identified by phase-contrast microscopy. The presence of HD in the hyaline cartilage of patients with knee OA was accompanied by more pronounced ultrasonographic signs of synovitis and was associated with a higher rate of osteophytes growth in the absence of the changes of the hyaline cartilage thickness according to the ultrasonography and the width of the joint space according to x-ray.Conclusion.The presence of HD in the hyaline cartilage of patients with knee OA according to ultrasound examination may be associated with the deposition of calcium pyrophosphate crystals and is associated with persistent synovitis and accelerated growth of osteophytes.

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Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Cited by 20 publications

References 73 publications

Pathogenetic and diagnostic role of osteoprotegerin in the combined course of osteoarthritis and obesity

Pathogenetic and diagnostic role of osteoprotegerin in the combined course of osteoarthritis and obesity

Epidemiology of knee osteoarthritis

Assessment of clinical significance of ultrasonographic detection ofhyperechogenic deposits in hyaline cartilage in patients with knee osteoarthritis

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