Osteoarthritis Flare-Up Secondary to Zoledronic Acid Infusion:  Case Report

Kiyumi, Maisa Hamed Al; Kiyumi, Maryam Al; Harrasi, Amira Al; Saidi, Yaqoub Al; Sumri, Hana Al; Shidhani, Asma Al; Sumri, Sanaa Al; Mahrezi, Abdulaziz Al

doi:10.5001/omj.2025.08

Oman Med J

2023

DOI: 10.5001/omj.2025.08

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Osteoarthritis Flare-Up Secondary to Zoledronic Acid Infusion: Case Report

Maisa Hamed Al Kiyumi¹,

Maryam Al Kiyumi²,

Amira Al Harrasi³

et al.

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2024

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Bilateral Knee Effusions Secondary to Zoledronic Acid Infusion

Wei,

Cho

2024

JCEM Case Reports

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Intravenous zoledronic acid is an established and generally well tolerated form of antiresorptive therapy for osteoporosis. Although mild arthralgias are a well-documented manifestation of the acute phase response to intravenous bisphosphonates, more severe musculoskeletal reactions manifesting as debilitating pain and joint effusions have been rarely documented in the current literature. In this case report, we discuss the case of a 55-year-old woman who developed severe painful bilateral knee effusions within 1 week of her first zoledronic acid infusion for osteoporosis. Prescribing physicians and patients should be made aware of this uncommon but important adverse effect to zoledronic acid.

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Bilateral Knee Effusions Secondary to Zoledronic Acid Infusion

Wei,

Cho

2024

JCEM Case Reports

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Osteoarthritis Flare-Up Secondary to Zoledronic Acid Infusion: Case Report

Cited by 1 publication

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Bilateral Knee Effusions Secondary to Zoledronic Acid Infusion

Bilateral Knee Effusions Secondary to Zoledronic Acid Infusion

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