Osteoarthritis Linked to Diabetes Characterized Sharp decreasing in Ser /Proline /PLCγ2 with Increasing PLCγ1, Where Inhibiting S6K/BTK / PLCγ2 Affect TXA2 Synthesis Cause C-lymphocytic Leukemia

Abstract

proper S6K /BTK and PLCγ2 are main regulations for thromboxane-A synthesis, and necessary for B-cell maturations and T-cells modulations and functions. The main factors that cause the Osteoarthritis “OA” and diabetes and linked between them are the deficiency of Ser amino acids and decreasing or down regulations of Ser phosphorylation signalling pathway which necessary for proper S6K productions, where normally the Ser phosphorylation signalling pathway is the basis of Ser /Thr phosphorylation signalling which normally necessary for proper Akt, S6K1 synthesis and necessary for RORs and IFNs synthesis and also necessary for running proper BTK and proper PLCγ2 productions , where S6K is main regulator for ATPase and for proper PLCγ1 and for PLCγ2 synthesis which necessary for bone growth and for increasing and modulating immune efficiency

Rac1 AT1 Required For Ang2-AT2 Activities For Cardiomyocytes And ECs Where Tyr TAT And TAC Kinases Required For Preventing Glycoprotein Storage And Glycogen Accumulation

“…Notice: dropping in estrogen synthesis will reflect dropping in Thymine and in cytosine kinase synthesis (pyrimidine kinases) which can produced from Ser/ Thr mTOR phosphorylation pathway [32] Pyrimidines kinases can ne obtained from Tyr TAT and TAC Codons required for ECs Ang2-AT2 synthesis that necessary for regulating heart contractions and blood flow in aorta.…”