Osteoarthritis (Osteoarthrosis; Degenerative Joint Disease)

Young, Diane M; Fetter, A.W.; Johnson, L.C.

doi:10.1016/b978-0-12-058502-1.50136-5

Cited by 3 publications

References 18 publications

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Articular cartilage proteoglycans from normal and osteoarthritic mice

Rostand

Baker

Caterson

et al. 1986

Arthritis & Rheumatism

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Articular cartilage proteoglycans from an osteoarthritic mouse strain, STR/IN, were labeled in vivo with 35S-sulfate and characterized with respect to extractability, ability to aggregate, size of monomer and glycosaminoglycan chains, sulfation of glycosaminoglycans, relative amounts of chondroitin-4 sulfate and chondroitind sulfate, and link proteins. The proportion of 35S-labeled proteoglycans extractable by 0.4M guanidine hydrochloride was the same in control and osteoarthritic animals. However, a greater proportion was extractable by 4M guanidine hydrochloride in the STRAN animals as compared with the control mice. The ability of the 35S-proteoglycans to aggregate was comparable in controls and osteoarthritic mice, as judged by their exclusion on Sepharose CL-2B. Monomers from both controls and osteoarthritic animals eluted from Sepharose CL-2B with a K A V of 0.47. Glycosaminoglycans from control and osteoarthritic animals eluted from Sepharose CL-6B with a K A v of 0.63, and do differences in sulfation or chondroitin-4 sulfate content were found. Aggregates were immunoprecipitated with link protein-specific antiserum, and only link protein 2

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Articular cartilage proteoglycans from normal and osteoarthritic mice

Rostand

Baker

Caterson

et al. 1986

Arthritis & Rheumatism

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Hereditary Progressive Ankylosis, Mouse

Sweet¹,

Bronson²

1991

Cardiovascular and Musculoskeletal Systems

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Early changes in the sulfation of chondroitin in guinea-pig articular cartilage, a possible predictor of osteoarthritis

Osborne¹,

Woodhouse²,

Meacock³

1994

Osteoarthritis and Cartilage

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Male Dunkin Hartley guinea-pigs have been shown to develop spontaneous osteoarthritis, in the knee joint, which is histologically apparent from the age of 3 months onwards. We have used capillary electrophoresis (CE) to examine subtle changes in the sulfation of chondroitin in guinea-pig articular and xiphisternal cartilage. An age-related increase in the 6:4 sulfation ratio of chondroitin was observed, with the medial tibial plateau developing more rapidly than the other joint surfaces. The observed sulfation patterns may be related to the onset of spontaneous osteoarthritis which, in the guinea-pig, develops initially on the medial tibial plateau. Chondroitin from patellar groove cartilage of animals between 3 and 12 months of age always had a significantly lower 6:4 sulfate ratio than the other joint surfaces.

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Osteoarthritis (Osteoarthrosis; Degenerative Joint Disease)

Cited by 3 publications

References 18 publications

Articular cartilage proteoglycans from normal and osteoarthritic mice

Articular cartilage proteoglycans from normal and osteoarthritic mice

Hereditary Progressive Ankylosis, Mouse

Early changes in the sulfation of chondroitin in guinea-pig articular cartilage, a possible predictor of osteoarthritis

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