Osteoarthritis prevalence and modifiable factors: a population study

Abstract

BackgroundThis study’s objectives were to investigate the prevalence of self-reported knee and hip osteoarthritis (OA) stratified by age and sex and to examine the association of modifiable factors with knee and hip OA prevalence. The study was conducted using randomly sampled data gathered from four communities in the province of Alberta, Canada.MethodsA large adult population sample (N = 4733) of individuals ≥18 years were selected. Health-related information was collected through telephone interviews and community measurement clinics for which a sub-sample (N = 1808) attended. Participants self-reported OA during telephone interviews. Clinic interviews further assessed if the diagnosis was made by a health care professional. Statistical analyses compared prevalence of OA between sexes and across age categories. Associations between modifiable factors for OA and the prevalence of knee and hip OA were assessed using binary logistic regression modelling.ResultsOverall prevalence of self-reported OA in the total sample was 14.8 %, where 10.5 % of individuals reported having knee OA and 8.5 % reported having hip OA. Differences in prevalence were found for males and females across age categories for both knee and hip OA. In terms of modifiable factors, being obese (BMI >30 kg/m2) was significantly associated with the prevalence of knee (OR: 4.37; 95 % CI: 2.08,9.20) and hip (OR: 2.52; 95 % CI: 1.17,5.43) OA. Individuals who stand or walk a lot, but do not carry or lift things during their occupational activities were 2.0 times less likely to have hip OA (OR: 0.50; 95 % CI: 0.26,0.96). Individuals who usually lift or carry light loads or have to climb stairs or hills were 2.2 times less likely to have hip OA (OR: 0.45; 95 % CI: 0.21,0.95). The odds of having hip OA were 1.9 times lower in individuals consuming recommended or higher vitamin C intake (OR: 0.52; 95 % CI: 0.29,0.96). Significant differences in prevalence were found for both males and females across age categories.ConclusionThe prevalence of knee and hip OA obtained in this study is comparable to other studies. Females have greater knee OA prevalence and a greater proportion of women have mobility limitations as well as hip and knee pain; it is important to target this sub-group.

Influence of morbid obesity on physical capacity, knee-related symptoms and overall quality of life: A cross-sectional study

“…27 Obesity is related with these changes by means of two interconnected pathways: increased load caused by excessive weight, and systemic effects related with chronic inflammation linked to imbalance in the release of active peptides produced by the fat tissue known as adipocytokines. 22,28,29 The assessment of knee-related symptoms using KOOS score in this study has shown impact mainly regarding pain and other symptoms compared with the mean values in non-obese individuals as reported in a systematic review by Collins et al 30 In a prospective study, Edwards et al 31 observed significant improvement in the five domains of KOOS following weight loss, while Gudbergsen et al 32 reported improvement in pain and function in daily living domains after weight loss. Thus, the results observed in our study regarding the KOOS methodology were similar to those previously observed in the literature.…”

Economic and Humanistic Burden of Osteoarthritis: A Systematic Review of Large Sample Studies

“…The Framingham Osteoarthritis Study estimated that the prevalence of radiographic and symptomatic hip OA was 19.6 and 4.2 %, respectively [4]. In Canada, the prevalence of selfreported OA was 14.8 % with 10.5 % on the knee and 8.5 % on the hip [5]. In Asia, the prevalence of symptomatic knee OA was 4.4 and 5.7 % in men and 19.2 and 10.3 % in women in Korea and China, respectively [6,7].…”

Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role

“…For example, with one study with 4733 subjects in Alberta, Canada, the prevalence of knee OA is 6.3% for males and 8.9% for females, while the prevalence of hip OA is 4.4% for males and 7.6% for females [12]. This discovery suggests presence of sex difference in OA prevalence and incidence, with females generally at a higher risk.…”