Osteoarthritis: The importance of hormonal status in midlife women

Dennison, Elaine

doi:10.1016/j.maturitas.2022.07.002

Cited by 20 publications

(12 citation statements)

References 32 publications

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“…If more than 95% of patients within the class were women or men, that class was named as a sex-specific disease class. One of these sex-specific classes included younger women (33 [ 29 , 37 ] years) who received perinatal care, and the other classes consisted of patients with multimorbidity. There were 7 MetS classes that showed high frequencies of type 2 diabetes, dyslipidemia, and hypertension simultaneously.…”

Section: Resultsmentioning

confidence: 99%

“…The decrease in estrogen levels in menopausal women is associated with an increased appetite [ 26 ], loss of subcutaneous fat, and an increase in intra-abdominal fat, which causes metabolic abnormalities in menopausal women [ 27 ]. Although epidemiological studies have suggested an association between osteoarthritis and natural menopause, the causal relationship between sex hormones and osteoarthritis remains unclear [ 28 , 29 ]. The present results support that obesity [ 30 ] and MetS might mediate postmenopausal osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

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Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association

Nishida,

Anzai,

Takahashi

et al. 2023

PLoS ONE

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Although the economic burden of multimorbidity is a growing global challenge, the contribution of multimorbidity in patients with high medical expenses remains unclear. We aimed to clarify multimorbidity patterns that have a large impact on medical costs in the Japanese population. We conducted a cross-sectional study using health insurance claims data provided by the Japan Health Insurance Association. Latent class analysis (LCA) was used to identify multimorbidity patterns in 1,698,902 patients who had the top 10% of total medical costs in 2015. The present parameters of the LCA model included 68 disease labels that were frequent among this population. Moreover, subgroup analysis was performed using a generalized linear model (GLM) to assess the factors influencing annual medical cost and 5-year mortality. As a result of obtaining 30 latent classes, the kidney disease class required the most expensive cost per capita, while the highest portion (28.6%) of the total medical cost was spent on metabolic syndrome (MetS) classes, which were characterized by hypertension, dyslipidemia, and type 2 diabetes. GLM applied to patients with MetS classes showed that cardiovascular diseases or complex conditions, including malignancies, were powerful determinants of medical cost and mortality. MetS was classified into 7 classes based on real-world data and accounts for a large portion of the total medical costs. MetS classes with cardiovascular diseases or complex conditions, including malignancies, have a significant impact on medical costs and mortality.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association

Nishida,

Anzai,

Takahashi

et al. 2023

PLoS ONE

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“…Of these, 176 (74.57%) were females and 60 (25.42%) were men. Nevertheless, early estrogen exposure (i.e., menarche at a younger age), parity, and menopause may offer hormonal and biomechanical reasons for the higher frequency of OA in females [13]. More than half of the women group is housewife, their sedentary life and lack of regular exercise may be risk factors for getting OA.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Smoking and Clinical and Radiological Severity in Patients with Primary Knee Osteoarthritis: The First Cross-sectional Study in Syria

Hamsho,

Almasri,

Alaswad

et al. 2023

Preprint

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Background: Osteoarthritis (OA) is a prevalent disease and a primary cause of disability globally. The most often impacted joints by OA are the knees. Furthermore; Smoking is a prevalent social behavior that has been linked to many illnesses. The purpose of this research is to ascertain whether smoking and knee OA are related in Syria. Methods: A cross-sectional study was conducted on 236 patients with primary knee OA who met the American College of Rheumatology (ACR) diagnostic criteria. Exclusion criteria encompassed various secondary diseases. Detailed smoking behavior and general demographic features were assessed. The clinical characteristics of OA were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the radiological severity was assessed using Kellgren and Lawrence (KL) grades for each patient. The sample size was determined using Cochran's formula, and statistical analysis was performed using SPSS 25, including chi-square tests, ANOVA, and linear correlation coefficients to assess relationships between variables. Results: The majority of OA patients (67.4%) were never smoking, which was followed by current smokers (27.1%) and former smokers (5.5%). There was no correlation between smoking status and total Womac, pain, stiffness, physical function, or radiographic severity, with p-values of 0.552, 0.437, 0.640, 0.796, and 1.109, respectively. The overall Womac score showed a significant gender difference (p-value = 0.002), with females showing an increase of 8.48 points over males. A correlation was found between average daily smoking, BMI, and gender, with p-values of 0.004 and 0.001, respectively. The difference in BMI was significant only between heavy smokers and never-smokers, with a difference of 3.54 (p-value =0.001) Conclusion: In individuals with osteoarthritis, there was no significant correlation between cigarette smoking and radiological results; nevertheless, there was an inverse relationship with mean WOMAC scores (smokers have lower WOMAC scores than never-smokers). It seems implausible that smoking actually prevents the progression of OA, even though it was found to be negatively correlated with the disease's progression either clinically or radiologically in the analysis. It will need further research to identify the mechanism behind this correlation.

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“…These findings suggest that being female and having KOA increase the likelihood of developing HV.It is also observed in clinical practice that there are similarities among individuals with KOA and HV. For instance, there is a higher prevalence of females, and factors such as age and lower limb deformities are commonly associated with both conditions [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Eligibility for knee arthroplasty is associated with increased risk of acquired hallux valgus - a Mendelian randomized study

Li,

Liu,

Shi

et al. 2024

BMC Musculoskelet Disord

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Objective Clinically, it has been found that patients undergoing knee replacement have a high incidence of concomitant hallux valgus. In this study, we analyzed whether patients with osteoarthritis who underwent surgery and those patient who did not have surgery had an increased risk of hallux valgus by Mendelian randomization and performed reverse causal analysis. Design Genomewide association study (GWAS) data for osteoarthritis, categorized by knee arthritis with joint replacement, knee arthritis without joint replacement, hip arthritis with joint replacement, and hip arthritis without joint replacement.And acquired hallux valgus were downloaded for Mendelian randomized studies. MR analysis was performed using inverse variance-weighted (IVW), weighted median, and MR-Egger methods. MR-egger regression, MR pleiotropic residuals and outliers (MR-presso), and Cochran's Q statistical methods were used to evaluate heterogeneity and pleiotropy. Results The IVW results indicate that, compared to healthy individuals, patients who meet the criteria for knee osteoarthritis joint replacement surgery have a significantly higher risk of acquired hallux valgus. There were no significant causal relationships found for the remaining results. No significant heterogeneity or multiplicity was observed in all the Mr analyses. Conclusion Our study supports the increased risk of acquired hallux valgus in patients eligible for knee replacement. There is necessary for clinicians to be concerned about the hallux valgus status of patients undergoing knee arthroplasty.

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Osteoarthritis: The importance of hormonal status in midlife women

Cited by 20 publications

References 32 publications

Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association

Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association

The Association Between Smoking and Clinical and Radiological Severity in Patients with Primary Knee Osteoarthritis: The First Cross-sectional Study in Syria

Eligibility for knee arthroplasty is associated with increased risk of acquired hallux valgus - a Mendelian randomized study

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