Osteoarthritis

Hunter, David J.; Bierma-Zeinstra, Sita M A

doi:10.1016/s0140-6736(19)30417-9

Cited by 2,916 publications

(2,667 citation statements)

References 133 publications

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“…Osteoarthritis is usually a slowly progressive disease that affects the entire joint, including articular cartilage, subchondral bone, ligaments, synovium, and even adjacent muscles [9][10][11][12]. The etiology of degenerative changes in the temporomandibular joints is complex.…”

Section: Introductionmentioning

confidence: 99%

“…In the pathogenesis of osteoarthritis, the mechanical, inflammatory, and metabolic factors are considered to be responsible for the damage of synovial joints [11,12]. The initiation and progression of the temporomandibular joint osteoarthritis may be influenced by injuries (as a result of injuries, the mechanical properties of the articular disc change, cartilage degradation, and the production of inflammatory and pain mediators), parafunctions (as a result of which dislocation of the articular disc may occur, as well as degenerative changes within the condyle and articular eminence), unstable occlusion, functional overload, and increased friction within the temporomandibular joint itself [2].…”

Section: Introductionmentioning

confidence: 99%

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Morphology of the Temporomandibular Joints Regarding the Presence of Osteoarthritic Changes

Derwich

Mituś-Kenig

Pawłowska

2020

IJERPH

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1) Osteoarthritis, the most common disease of the temporomandibular joints (TMJs), is diagnosed by clinical and radiographic examination. Cone beam computed tomography (CBCT) is a method of choice for the imaging of osteoarthritic changes. The objective was to compare the morphology of the TMJs in CBCT images regarding the number of the osteoarthritic changes diagnosed in the area of the condyle. (2) A total of 105 patients participated in the study; their 210 TMJs were allocated into one of three groups regarding the number of diagnosed osteoarthritic changes: 1 (none or 1 type), 2 (2 types), 3 (3 or more types). The morphology of the TMJ was examined for each TMJ in the CBCT images. Statistical analysis was performed with STATISTICA version 12.0. The statistical significance level was p = 0.05 for all the measurements included. (3) The articular surface flattening was the most common type of the osteoarthritic changes (90%). The condylar A-P dimension differed significantly among the groups (p = 0.0001). The bigger the number of osteoarthritic changes diagnosed in one joint, the smaller the condylar A-P dimension that was observed. (4) The temporomandibular joints' osteoarthritic changes occur very often, even among asymptomatic patients. The increased number of osteoarthritic changes seems to have an impact on the condylar anteroposterior dimension. Author Contributions: Conceptualization, M.D.; methodology, M.D.; validation, M.D., M.M.-K., and E.P.; formal analysis, M.D.; investigation, M.D.; resources, M.D.; writing-original draft preparation, M.D.; writing-review and editing, M.M.-K. and E.P.; visualization, M.D.; supervision, M.M.-K. and E.P.; project administration, M.D., M.M.-K., and E.P. All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Conflicts of Interest:The authors declare no conflict of interest.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphology of the Temporomandibular Joints Regarding the Presence of Osteoarthritic Changes

Derwich

Mituś-Kenig

Pawłowska

2020

IJERPH

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“…Osteoarthritis (OA), the leading cause of physical disability in adults, is a degenerative disease of synovial joints characterised by inflammation, bone remodelling, and progressive degradation of articular cartilage 1 . There is a need for robust biomarkers which identify the onset of disease, enable monitoring of progression, and efficacy of potential therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

Clusterin secretion is attenuated by pro-inflammatory cytokines in culture models of cartilage degradation

Matta

Fellows

Quasnichka

et al. 2020

Preprint

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Proteomic studies have implicated clusterin as a potential biomarker of osteoarthritis (OA). However, there are two isoforms of clusterin with opposing functions, and their roles in OA have not previously been clarified. The secreted form of clusterin (sCLU) is a cytoprotective extracellular chaperone which prevents protein aggregation and enhances cell proliferation and viability, whereas nuclear clusterin (nCLU) acts as a pro-death signal. In this study, we focused on the role of sCLU and used established, pathophysiologically relevant, in vitro culture models to validate this potential biomarker of cartilage degradation. The secretome of equine cartilage explants, osteochondral biopsies and chondrocytes was analysed by western blotting for released sCLU, cartilage oligomeric protein (COMP) and matrix metalloproteinases (MMP) 3 and 13, following treatment with or without pro-inflammatory cytokines interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α). The amount of sulphated glycosaminoglycans (sGAG) released into the medium was determined by dimethylmethylene blue (DMMB) analysis. Clusterin mRNA expression was quantified by real-time PCR. MMP-3, MMP-13, COMP and sGAG released from explants and osteochondral biopsies was elevated with cytokine treatment, confirming cartilage degradation in these models. Release of sCLU was attenuated with cytokine treatment in all three in vitro models.Expression of clusterin mRNA in cartilage explants and chondrocytes was down-regulated 7days post cytokine stimulation. Cytokine stimulation attenuated expression and secretion of sCLU, therefore potentially limiting the cytoprotection which sCLU provides. These observations further implicate sCLU as having a role in OA, and diagnostic value as a potential biomarker for cartilage degradation. (245 words in abstract) C. Matta et al. Enhanced clusterin release in osteoarthritis 4

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“…Articular cartilage defects, when left untreated or partially healed, dramatically increase the predisposition to osteoarthritis (OA). OA is a painful, debilitating, and slowly progressing degenerative and inflammatory joint disease that is initiated by cartilage damage prior to its culmination in alteration of all of the joint tissues (i.e., synovium, bone, muscle, tendon, and ligament) (Hunter and Bierma-Zeinstra, 2019). As there is no curative treatment, prosthetic joint replacement remains the last-recourse for alleviation of OA-associated pain symptoms .…”

Section: Introductionmentioning

confidence: 99%

A Self-Setting Hydrogel of Silylated Chitosan and Cellulose for the Repair of Osteochondral Defects: From in vitro Characterization to Preclinical Evaluation in Dogs

Boyer

Réthoré

Weiss

et al. 2020

Front. Bioeng. Biotechnol.

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Articular cartilage (AC) may be affected by many injuries including traumatic lesions that predispose to osteoarthritis. Currently there is no efficient cure for cartilage lesions. In that respect, new strategies for regenerating AC are contemplated with interest. In this context, we aim to develop and characterize an injectable, self-hardening, mechanically reinforced hydrogel (Si-HPCH) composed of silanised hydroxypropymethyl cellulose (Si-HPMC) mixed with silanised chitosan. The in vitro cytocompatibility of Si-HPCH was tested using human adipose stromal cells (hASC). In vivo, we first mixed Si-HPCH with hASC to observe cell viability after implantation in nude mice subcutis. Si-HPCH associated or not with canine ASC (cASC), was then tested for the repair of osteochondral defects in canine femoral condyles. Our data demonstrated that Si-HPCH supports hASC viability in culture. Moreover, Si-HPCH allows the transplantation of hASC in the subcutis of nude mice while maintaining their viability and secretory activity. In the canine osteochondral defect model, while the empty defects were only partially filled with a fibrous tissue, defects filled with Si-HPCH with or without cASC, revealed a significant osteochondral regeneration. To conclude, Si-HPCH is an injectable, self-setting and cytocompatible hydrogel able to support the in vitro and in vivo viability and activity of hASC as well as the regeneration of osteochondral defects in dogs when implanted alone or with ASC.

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Osteoarthritis

Cited by 2,916 publications

References 133 publications

Morphology of the Temporomandibular Joints Regarding the Presence of Osteoarthritic Changes

Morphology of the Temporomandibular Joints Regarding the Presence of Osteoarthritic Changes

Clusterin secretion is attenuated by pro-inflammatory cytokines in culture models of cartilage degradation

A Self-Setting Hydrogel of Silylated Chitosan and Cellulose for the Repair of Osteochondral Defects: From in vitro Characterization to Preclinical Evaluation in Dogs

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