Osteoarthropathy of hepatolenticular degeneration

Renal tubular acidosis due to Wilson's disease presenting as metabolic bone disease

“…Radiographic abnormalities described include osteoporosis/osteopaenia, osteomalacia (rickets in children) and some distinct changes like marginal bone fragments, angulation of carpal bones, squaring of metacarpal heads and calcification of the joint capsule or tendon insertion 4. Radiographic evidence of osteoporosis is present in up to 88% of persons with Wilson’s disease 3 5. Joint involvement, particularly knees and spine, is also common, and joint pain may be the presenting symptom of Wilson’s disease 5.…”

“…Radiographic evidence of osteoporosis is present in up to 88% of persons with Wilson’s disease 3 5. Joint involvement, particularly knees and spine, is also common, and joint pain may be the presenting symptom of Wilson’s disease 5. A sole case of Wilson’s disease presenting with RTA and osteomalacic osteodystrophy has been reported 6.…”

Manifestations rhumatologiques associées à la maladie de Wilson

“…Des anomalies radiologiques ont été décrites sur une dizaine de petites séries ouvertes [11][12][13][14][15][20][21][22]. La principale anomalie était une arthrose précoce, notamment des genoux, des hanches et des poignets, et touchant selon les séries, de 7 à 60 % des patients, sur des échantillons d'âge moyen entre 25 et 30 ans.…”

The ever-expanding conundrum of primary osteoporosis: aetiopathogenesis, diagnosis, and treatment

“…Bone and joint involvement are under-recognised components of WD, with radiographic evidence of osteoporosis present in up to 88% of persons with the disease [117-119] that may result in spontaneous fractures. Joint involvement, particularly of the knees, is also common, and joint pain has been reported as the presenting symptom of WD [119].…”

“…Joint involvement, particularly of the knees, is also common, and joint pain has been reported as the presenting symptom of WD [119]. Radiological evidence of vertebral column abnormalities is evident in 20 to 33% of individuals with WD [117,120].…”