Osteoarticular and pulmonary manifestations of acute leukemia. Case report and review of the literature

Marsh, W.; Bylund, David J.; Heath, Victor C.; Anderson, Michael J.

doi:10.1002/1097-0142(19860115)57:2<385::aid-cncr2820570233>3.0.co;2-l

Cited by 25 publications

(4 citation statements)

References 35 publications

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“…Because of nonspecific or absent hémato¬ logie abnormalities, the diagnosis of leu¬ kemia was delayed an average of 5Vi weeks.1 In other studies, the correct diagnosis of leu¬ kemia was delayed 1 to 24 months. [2][3][4][5][6][7][8][9] These children often are initially referred to pédiatrie rheumatologists for evaluation of collagen vascular dis¬ ease.2'3310 Most of these patients with malignant neoplasm do not have clinical features that distinguish their arthritis from that of children with rheumatic diseases,1"35 and one fifth have normal complete blood cell counts. 7 We studied the possibility that in¬ creased serum lactate dehydrogenase (LDH) levels are an indicator of neoplastic disease in children who present with arthritis and unremarkable complete blood cell counts and blood smears.…”

mentioning

confidence: 73%

The Discriminating Value of Serum LactateDehydrogenase Levels in Children With Malignant Neoplasms Presenting as Joint Pain

Wallendal¹,

Stork²,

Hollister

1996

Arch Pediatr Adolesc Med

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confidence: 73%

The Discriminating Value of Serum LactateDehydrogenase Levels in Children With Malignant Neoplasms Presenting as Joint Pain

Wallendal¹,

Stork²,

Hollister

1996

Arch Pediatr Adolesc Med

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“…The most common MSM are localized or diffuse bone pain, limp, arthritis, myalgia, failure to use an extremity, as well as other complaints mimicking orthopedic conditions such as osteomyelitis [5][6][7]. In addition, the affected individuals present an increased risk for fractures [2,6,8].…”

Section: Introductionmentioning

confidence: 99%

“…Musculoskeletal manifestations (MSM) associated with acute lymphoblastic leukemia (ALL) in children are common findings with a prevalence estimated between 11.6 and 50% [1][2][3][4]. The most common MSM are localized or diffuse bone pain, limp, arthritis, myalgia, failure to use an extremity, as well as other complaints mimicking orthopedic conditions such as osteomyelitis [5][6][7]. In addition, the affected individuals present an increased risk for fractures [2,6,8].…”

Section: Introductionmentioning

confidence: 99%

Acute lymphoblastic leukemia in children: Correlation of musculoskeletal manifestations and immunophenotypes

Maman

Steinberg

Stark

et al. 2007

Journal of Children's Orthopaedics

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Purpose Studies on musculoskeletal manifestations (MSM) of childhood acute lymphoblastic leukemia (ALL) have yielded variable findings with regard to their clinical impact. We investigated the significance for differential diagnosis, treatment and outcome of musculoskeletal complaints as presenting symptoms of ALL, and their correlation with leukemia immunophenotypes, for which data is lacking. Methods Data on 783 children in the national study for childhood ALL between 1984 and 2003 were reviewed retrospectively. Statistical analysis examined possible relationships between MSM at the time of diagnosis and demographic and clinical data, biological features of leukemia (peripheral blood counts, immunophenotype and main cytogenetic aberration), response to initial prednisone treatment, and outcome.Results Of 765 children with data on orthopaedic complaints, 240 presented with MSM (31.4%). Among these children, B cell precursor (BCP) was much more common (209/576, 36.3%) than T cell ALL (25/176, 14.2%). Patients with MSM had lower white blood cell counts (WBC) (median of 9 vs. 20 · 10 9 /L, P < 0.001) and percentage of blast cells in the peripheral blood at diagnosis compared to those without (median of 27 vs. 53%, P < 0.001). Hepatomegaly and splenomegaly were less common in MSM group (67 vs. 53% <3 cm, P < 0.001, and 63 vs. 50% <3 cm, P < 0.001, respectively). Poor response to initial treatment with prednisone was recorded in 7.1% of patients with MSM versus 11.5% of those without (P = 0.086). The analysis revealed no independent effect of MSM on event-free survival (EFS), after correcting for differences in EFS related to immunophenotype or initial WBC. Conclusions MSM occur mostly in children with BCP ALL who present with less involvement of extramedullary organs, low peripheral blood blasts and white blood cells counts. These findings highlight the importance of including ALL in the differential diagnosis of MSM even in the presence of an apparently normal peripheral blood count. Our study also suggests that MSM are caused by leukemic cells with enhanced biological propensity to remain relatively confined within the intramedullary bone-marrow space.

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“…3 Skeletal manifestations associated with Acute lymphoblastic leukemia (ALL) in children are common findings with a prevalence estimated between 11.6 and 50%. 4,5 The most common skeletal manifestations are localized or diffuse bone pain, arthritis, failure to use an extremity, as well as other complaints mimicking orthopedic conditions such as osteomyelitis. In addition, the affected individuals present an increased risk for fracture.…”

Section: Introductionmentioning

confidence: 99%

Skeletal Manifestations in Acute Lymphoblastic Leukaemia

Begum¹,

Fatmi

Islam

et al. 2019

Bangladesh J Child Health

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Background: Skeletal manifestations associated with ALL in children are common findings with a high prevalence (11.6 to 50%). The most common skeletal manifestations are bone pain, arthritis, failure to use an extremity as well as other complaints mimicking orthopedic condition such as osteomyelitis. The objective of this study is to determine the rate of skeletal manifestations commonly present in ALL to reduce mortality and morbidity. Methods: This cross-sectional study was carried out in the department of Pediatrics in Dhaka medical college Hospital, BSMMU and Dhaka Shishu (Children) Hospital between January 2010 to July 2010. Total Fifty patients of ALL were Selected consecutively from the study population. At first, we assessed skeletal manifestations like bone pain, arthritis, radiological findings present or not in ALL. Then specify the rate of bone pain, arthritis, radiological findings of ALL patients. Results: After six months 35 patients were present with skeletal manifestations. Among them 20 patients, presented with bone pain,10 patients presented with arthritis and 5 patients presented with radiological manifestations. Out of 5 patients 3 patients had soft tissue swelling 1 patient had periarticular osteoporosis and 1 patient had joint effusion in x-ray findings. Conclusion: Skeletal manifestations may be the only presentation in ALL. Bangladesh J Child Health 2019; VOL 43 (2) :102-105

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Osteoarticular and pulmonary manifestations of acute leukemia. Case report and review of the literature

Cited by 25 publications

References 35 publications

The Discriminating Value of Serum LactateDehydrogenase Levels in Children With Malignant Neoplasms Presenting as Joint Pain

The Discriminating Value of Serum LactateDehydrogenase Levels in Children With Malignant Neoplasms Presenting as Joint Pain

Acute lymphoblastic leukemia in children: Correlation of musculoskeletal manifestations and immunophenotypes

Skeletal Manifestations in Acute Lymphoblastic Leukaemia

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