Osteoarticular and soft-tissue melioidosis in Malaysia: clinical characteristics and molecular typing of the causative agent

Zueter, AbdelRahman; Abumarzouq, Mahmoud; Yusof, Mohd Imran; Ismail, Wan Faisham Wan; Harun, Azian

doi:10.3855/jidc.7612

Cited by 12 publications

(15 citation statements)

References 19 publications

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“…Various studies have reported human infections by B . thailandensis belonging to both cluster I (ST77, ST80 and ST345) and cluster II (ST73 and ST101) (https://pubmlst.org/bpseudomallei/) [5–10]. It has been postulated that B .…”

Section: Resultsmentioning

confidence: 99%

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Identification of Burkholderia thailandensis with novel genotypes in the soil of central Sierra Leone

et al. 2019

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Background The soil-dwelling bacillus Burkholderia pseudomallei is the etiological-agent of the neglected and life-threatening emerging infection melioidosis. The distribution of B . pseudomallei in West Africa is unknown. In the present study we aimed to determine whether B . pseudomallei and B . thailandensis are present in the environment of central Sierra Leone. Methodology/Principal findings In June-July 2017, we conducted an environmental surveillance study–designed in accordance with existing consensus guidelines—in central Sierra Leone. A total of 1,000 soil samples (100 per site) were collected and cultured. B . pseudomallei was not identified in the soil, but we identified seven novel B . thailandensis sequence types with multi-locus sequence typing (MLST) and 16S rRNA gene sequence analyses. Conclusions/Significance The presence of B . pseudomallei was not demonstrated, however, multiple novel B . thailandensis sequence types were identified. More environmental and sequencing studies are needed to further understand the genetic diversity, evolution and virulence of these emerging organisms.

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Section: Resultsmentioning

confidence: 99%

“…thailandensis is a member of the B . pseudomallei complex, is considered a-virulent [3,4] and rarely causes disease in humans [5–10]. Knowledge about the global distribution of B .…”

Section: Introductionmentioning

confidence: 99%

Identification of Burkholderia thailandensis with novel genotypes in the soil of central Sierra Leone

et al. 2019

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“…Even the possibility of co-infection of melioidosis and TB was not suspected. B. pseudomallei is well known to cause latent infection [17], although it is not documented that whether the anti-tubercular treatment has any effect in suppressing the bacteria Bone and joint involvements like septic arthritis and osteomyelitis are very well-documented clinical presentations in melioidosis [18], whereas pulmonary involvement was more commonly observed in TB. The extra-pulmonary involvement is more common in melioidosis than TB and less challenging in diagnosis, still it is missed most often [19,20].…”

Section: Discussionmentioning

confidence: 99%

Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise

Garg

Shaw

Vandana

et al. 2020

J Infect Dev Ctries

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Introduction: Melioidosis, caused by the soil saprophyte B. pseudomallei, is a ‘neglected’ infectious disease in many Asian countries. It remained undiagnosed or misdiagnosed in India for long due to a lack of awareness and facilities to diagnose the disease; however, it is slowly gaining the status of an emerging disease recently. The disease is well known as a great mimicker, as the presentations are very similar to many other tropical diseases, and more importantly, to tuberculosis . Methodology: A prospective observational study was conducted from January 2016 – December 2018 to find the occurance of melioidosis in patients with ‘recurrent’ tuberculosis infection in a tertiary health care hospital from southern India. All suspected cases of recurrent tuberculosis were simultaneously tested for the presence of B. pseudomallei, and basic demographics and clinical details were documented. Result: Among 11,138 patients admitted with suspected tuberculosis infection, 586 (5.2%) patients were confirmed. There was recurrent Mycobacterium tuberculosis infection in 11/586 (1.8%) cases, and 7/586 (1.2%) had growth of B. pseudomallei in culture. Patients with melioidosis had either pulmonary involvement, or bone and joint infections and deep abscesses. Uncontrolled diabetes mellitus was the major risk factor. Conclusion: The study foreshadows the need for prompt and accurate microbiological diagnosis along with a high index of suspicion from the clinicians in countries which are endemic for both melioidosis and tuberculosis, thus ameliorating the irrational anti-tuberculosis treatment.

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“…The antibiotic medication used should have a good penetration into the brain tissue as well as activity against B. pseudomallei . The drug of choice for the treatment of melioidosis are ceftazidime or meropenem, alone or with SXT [16].…”

Section: Discussionmentioning

confidence: 99%

Multi-systemic melioidosis: a clinical, neurological, and radiological case study from Hainan Province, China

Huang

Chen

et al. 2018

BMC Infect Dis

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BackgroundMelioidosis is a tropical disease caused by Burkholderia pseudomallei (B. pseudomallei). It can infect any organ system and lead to multiple abscesses. A few studies reported that central nervous system (CNS) is also involved.We present a diabetic patient with multi-systemic melioidosis that affected the CNS, thorax, and spleen. The aim was to study the clinical and radiological features of melioidosis and enhance understanding of the disease.Case presentationA 38-year-old male presented with cough and expectoration mixed with blood for several days. Chest computed tomography (CT) showed a patchy opacity in his left lung, and multiple low-density lesions in his spleen. After 10 days of antibiotics treatment, his clinical symptoms improved and he was discharged from the hospital. But 8 months later, the patient experienced sudden onset of left limb weakness and seizure and was re-admitted to the hospital. Brain CT indicated a low-density lesion over the right frontal lobe, and magnetic resonance imaging (MRI) indicated a well-enhanced lobulated lesion with multiple diffusion restriction areas in the lesion. He had a neuronavigation-guided open surgery but no malignancy was found. B. pseudomallei was cultured from the operative samples. After 4 months of systemic and intraventricular antibiotic administration treatment, he recovered complete consciousness with left hemiparesis.ConclusionsMulti-systemic melioidosis may present atypical clinical, neurological, and radiological manifestations. It is extremely important to accurately diagnose before treatment is selected. CNS melioidosis in early stage manifests similar symptoms to malignancy or stroke. It might mislead to a false diagnose. Diffusion weighted imaging (DWI) can help in differentiate abscesses from cystic tumours.

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Osteoarticular and soft-tissue melioidosis in Malaysia: clinical characteristics and molecular typing of the causative agent

Cited by 12 publications

References 19 publications

Identification of Burkholderia thailandensis with novel genotypes in the soil of central Sierra Leone

Identification of Burkholderia thailandensis with novel genotypes in the soil of central Sierra Leone

Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise

Multi-systemic melioidosis: a clinical, neurological, and radiological case study from Hainan Province, China

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