Osteoarticular infection in intravenous drug abusers: influence of HIV infection and differences with non drug abusers.

Abstract

Objectives-To determine (a) the influence of HIV in developing osteoarticular infections in intravenous drug abusers (IVDAs) and (b) the differences between the clinical features of osteoarticular infections in IVDAs and a control group of non-IVDAs. Methods-A comparative study of the clinical features of osteoarticular infections in all HIV positive and HIV negative IVDAs admitted to the departments of rheumatology and internal medicine during a 10 year period was carried out.

Pyogenic arthritis of native joints in non-intravenous drug users: A detailed analysis of 268 cases attended in a tertiary hospital over a 22-year period

“…Staphylococci were by far the major etiologic agent, being responsible for almost 90% of cases. Notably, our data show that the current clinical and bacteriological picture of pyogenic arthritis in IVDUs has remained similar to that reported during the early 1990s [4,18], although the possibility of MRSA infection is now an added consideration [19].…”

Microbiology of Bone and Joint Infections in Injecting Drug Abusers

“…In contrast, Chandrasekar and Narula [6] reported S aureus was the most common pathogen, identified in 56% (25 of 45) of their patients, whereas P aeruginosa was present in 11% (five of 45). Other studies from the 1980 s and later found S aureus present in 55 to 77% of musculoskeletal infections in patients with IDA [2,4,5,13,15]. We found S aureus was the infecting microorganism in the majority of cases (52%, 111 of 215) with P aeruginosa in only 7% (15 of 215) of infections.…”

“…The existing literature has found rates of ORSA infections that vary from 0 to 36% of all infections but nothing has been reported in the past 10 years. Moreover, only three studies evaluated a series of patients treated in the same institution over a time period of 8 years or more but did not assess changes in resistance patterns [4,15,18]. S aureus was not a major pathogen in an early study [18] and two subsequent studies did not report ORSA data [4,15].…”

“…Moreover, only three studies evaluated a series of patients treated in the same institution over a time period of 8 years or more but did not assess changes in resistance patterns [4,15,18]. S aureus was not a major pathogen in an early study [18] and two subsequent studies did not report ORSA data [4,15]. Many of the existing studies have focused on patients with septic arthritis only and the remaining studies have reported on small numbers of patients with osteomyelitis that was hematogenous or contiguous in origin.…”

Pathologic dislocation of the shoulder secondary to septic arthritis: a case report

“…Intravenous drug abuse, itself, can be considered a risk factor for articular infection [13]. Ang-fonte et al attribute a fourfold increase of septic arthritis to this factor [6].…”