Osteocalcin: A new phenomenon for type 2 diabetes and obesity

Abstract

<b>Objectives: </b>The molecular biology revolution has emerged with the determination that bone tissue is an endocrine organ that regulates many physiological processes, and osteocalcin (OCN), an osteoblast-derived protein that provides endocrine control, is a hormone that regulates glucose and energy homeostasis. By controlling gene expression in β-cells and adipocytes, OCN improves glucose intolerance, obesity, and insulin expression. In addition, OCN stimulates the secretion of adiponectin, a molecule that increases fatty acid oxidation and insulin secretion and sensitivity in adipose tissue and reduces adipose tissue accumulation. Recent research suggests that serum OCN increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and uncoupling protein-1 (UCP1) genes, which play a role in thermogenesis in brown adipose tissue, it also affects insulin sensitivity by increasing adiponectin expression in white adipose tissue. OCN the target gene of insulin, and resting energy expenditure and mitochondrial biogenesis. With all these effects, OCN is a protein that has recently been found to be associated with diabetes and obesity components.<br /> <b>Conclusions: </b>This review aims to present an overview of understanding the interaction of OCN produced by osteoblasts with insulin, glucose metabolism, adipose tissue, skeletal and muscle tissue, and appetite metabolism in understanding the endocrine functions of bone. In addition, it was conducted to examine the role of OCN in energy metabolism and to evaluate the relationship of energy metabolism pathways affected by OCN with non-communicable chronic diseases such as type 2 diabetes mellitus and obesity.

Links among Obesity, Type 2 Diabetes Mellitus, and Osteoporosis: Bone as a Target

“…Osteocalcin (OC), which is lower in obese subjects and is considered a bone formation marker, improves glucose intolerance, obesity, and insulin expression by controlling gene expression in β-cells and adipocytes. In addition, it stimulates adiponectin secretion [11,63]. Osteopontin is elevated in obese individuals and is involved in physiological and pathological bone mineralization.…”

Preptin: A New Bone Metabolic Parameter?

“…Indeed, higher osteocalcin levels were reported to be associated with greater insulin sensitivity, lower BMI and lower systolic blood pressure [ 66 , 67 ], while T2M and obesity were associated with lower osteocalcin concentrations [ 66 , 68 ]. The active, undercarboxilated form of osteocalcin synthesized by osteoblasts exhibits various endocrine functions, among which are the regulation of insulin synthesis and secretion and also the increase in insulin sensitivity [ 69 ].…”