Osteocalcin association with vascular function in chronic kidney disease

Abstract

Osteocalcin (OCN) is a bone-derived and vitamin K dependent hormone that affects energy metabolism and vascular calcification. The relationship between serum OCN and vascular function in patients with chronic kidney disease (CKD) is uncertain. This study investigated the association between serum OCN and vascular function as expressed with reactive hyperemia index (RHI) and augmentation index (AIx) measured by Endo-PAT 2000 device. This cross-sectional analysis was based on 256 pre-dialysis CKD patients who had completed the Endo-PAT 2000 test and serum OCN at the First Center of Chinese PLA Hospital from November 2017 to December 2019. Based on whether the RHI was less than 1.67, the patients were divided into endothelial dysfunction and normal endothelial function groups. Multiple logistic and linear regression were used to analyze the association between OCN and vascular function. Subgroup analyses were performed to examine the effects of OCN on vascular function in different CKD populations. After mul-tivariate adjustment, CKD with low OCN were more likely to have endothelial dysfunction (OR: 0.794; 95%CI: 0.674-0.934; P = .006); on the contrary, patients with high OCN had a higher degree of arterial stiffness (standardized β: 0.174; P = .003). Subgroup analyses showed that higher OCN was associated with severe arterial stiffness but a better endothelial function in young (age < 65 years, P RHI /P AIx@75 = .027/.011), male (P RHI /P AIx@75 = .040/.016), patients with a history of hypertension (P RHI /P AIx@75 = .004/.009) or diabetes (P RHI /P AIx@75 = .005/.005), and in early CKD (P RHI /P AIx@75 = .014/.015). In conclusion, serum OCN correlates with vascular function in CKD patients: beneficial for endothelial function but detrimental to arterial stiffness.

Endothelial function in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors is not related to cardiovascular risk assessed by SCORE2 algorithm

“…It was an intriguing finding that the skin microcirculation response (RHR [%]) assessed using the FMSF method, rather than the FMD or RH-PAT responses, was negatively correlated with the duration of TKI's treatment even after adjustment for a patient's age. These results are in line with results from previous studies that assessed age-dependent deterioration of endothelial function using FMD, RH-PAT, or FMSF [39][40][41]. However, when our results were adjusted for patients' age, correlations with FMSF were independent of age whereas correlations with FMD after adjustment were weaker.…”

Current and Emerging Markers and Tools Used in the Diagnosis and Management of Chronic Kidney Disease–Mineral and Bone Disorder in Non-Dialysis Adult Patients

“…Osteocalcin correlated negatively with renal function in a small study of non-dialysis CKD patients [124], and other investigations have identified a link to cardiovascular risks: a cross-sectional analysis of 256 non-dialysis CKD patients found that low levels of total osteocalcin were associated with endothelial dysfunction, whereas participants with high osteocalcin levels had a greater degree of arterial stiffness [125]. Additionally, a further study focusing on the uncarboxylated form of osteocalcin (ucOC) demonstrated that decreased ucOC levels were closely correlated with subclinical carotid atherosclerosis in non-dialysis CKD patients [126].…”

Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview

“…Although not directly correlated to vascular calcification, low osteocalcin levels are associated with increased arterial stiffness and carotid atherosclerosis in CKD patients [ 146 , 147 ].…”