Osteocalcin Levels in Patients with Hyper- and Hypothyroidism

Martinez, Mariana; Herranz, Lucrecia; Pedro, C.; Pallardo, Luís Felipe

doi:10.1055/s-2007-1012275

Cited by 31 publications

(14 citation statements)

References 4 publications

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“…OCN is synthesized specifically by mature osteoblasts and then deposited in bone or secreted into serum (Hauschka et al, 1989). The serum level of OCN, which is now used widely as a clinical indicator of osteoblastic activity, is increased in hyperthyroidism (Martinez et al, 1986;Mosekilde et al, 1990). In our in vitro study, short-term treatment with T3 increased the production of OCN and the level of its mRNA in RC cells (Figs.…”

Section: Isolated Fetal Rc Cells Contain a Subpopulation Of Osteoprogmentioning

confidence: 52%

Thyroid hormone suppresses the differentiation of osteoprogenitor cells to osteoblasts, but enhances functional activities of mature osteoblasts in cultured rat calvaria cells

Ohishi¹,

Ishida²,

Nagata³

et al. 1994

Journal Cellular Physiology

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The effects of thyroid hormone on osteoblastic differentiation and activity were studied in fetal rat calvaria (RC) cells cultured for up to 30 days in medium supplemented with thyroid hormone-depleted serum. In this condition, the cells proliferated and differentiated to form mineralized bone nodules (BN) and expressed osteoblastic markers such as alkaline phosphatase (ALP), osteocalcin (OCN), and osteopontin (OPN). The continuous presence of triiodothyronine (T3) at 10(-9)-10(-8) M in the medium inhibited the osteoblastic differentiation: 34% decrease in ALP activity on day 12 and 60% decrease in BN formation on day 15 at 10(-8) M. T3 at these doses had no effect on the DNA content of RC cells at confluence (day 6). Short-term (48-h) exposure of T3 at 10(-9) M or higher decreased ALP activity when RC cells were differentiating (days 7-11). However, when BN formation by the cells had already reached a plateau (day 28), the activity was increased by treatment with T3 at 10(-7)-10(-6) M. OCN production was increased dose dependently by this treatment with T3 (2.1-fold and 1.3-fold of control at 10(-8) M on days 11 and 28, respectively). Similar increases were observed in the levels of OCN mRNA. In addition, increases in phosphorylated OPN in the medium (day 11) and mineralized matrix (day 28) were observed (1.5-fold at 10(-8)-10(-6) M), while OPN synthesis and the level of its mRNA were depressed by T3 (60-70% of control at 10(-8) M). These results suggest that T3 regulates osteoblastic differentiation and activity depending on the state of cell differentiation: T3 suppresses the differentiation of osteoprogenitor cells to osteoblasts, but enhances the functional activity of mature osteoblasts.

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Section: Isolated Fetal Rc Cells Contain a Subpopulation Of Osteoprogmentioning

confidence: 52%

Thyroid hormone suppresses the differentiation of osteoprogenitor cells to osteoblasts, but enhances functional activities of mature osteoblasts in cultured rat calvaria cells

Ohishi¹,

Ishida²,

Nagata³

et al. 1994

Journal Cellular Physiology

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“…There were no significant AP changes during this period Faber et al, 1991. likewise found that the drug treatment of hyper-or hypothyroidism normalized the BGP serum levels as soon as an euthyroid state was reached Martinez et al, 1985 andGarrel et al, 1986. also demonstrated that the BGP levels correlated better with the thyroid hormone levels in serum than with alkaline phosphatase and hydroxyproline.…”

mentioning

confidence: 63%

“…The BGP serum levels correlate with histomorphometric parameters of osteoblastic activity (Delmas et al, 1985;Stracke et al, 1987). Whereas increased BGP levels are observed in untreated hyperthyroidism, they were found to be decreased in hypothyroid patients (Martinez et al, 1985;Garrel et al, 1986;Bergmann et al, 1989;Faber et al, 1991). There was a positive correlation between BGP and the concentrations of free triiodothyronine and alkaline phosphatase, but a significantly negative correlation with the serum PTH levels (Yoneda et al, 1988).…”

mentioning

confidence: 93%

BGP Serum Levels in Patients with Thyroid Carcinoma before and 4 — 14 Weeks after Radioiodine Therapy

Stracke¹,

Federlin²

2009

Exp Clin Endocrinol Diabetes

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In the present short paper we compared the BGP and AP levels of 26 patients with thyroid carcinoma during radio-iodine therapy. BGP values reflect the bone turnover before and after radio-iodine therapy. There were no significant AP changes during this period. These results suggest that thyroid hormone has a direct effect on osteoblast function and that this effect can be best monitored by determination of BGP levels.

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“…The results indicate that single doses around 800 pg beclomethasone may acutely depress serum cortisol (21). One of the major adverse effects of GC treatment, however, is suppression of (19,(22)(23)(24)(25)(26)(27)(28)(29)(30). The metabolic clearance is mainly dependent on renal function (31), and the serum half-life of osteocalcin is approximately 20 min in man (32).…”

Section: Discussionmentioning

confidence: 99%

The effect of single doses of inhaled beclomethasone dipropionate on the circadian rhythm in serum osteocalcin in normals

Nielsen

Pedersen²,

Brixen³

et al. 1993

Acta Endocrinologica

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The effect of single doses of inhaled beclomethasone dipropionate on the circadian rhythm in serum osteocalcin in normals. Acta Endocrinol 1993;128:263-7. ISSN 0001-5598 A single dose of 2.5 mg prednisone leads to a significant transient decrease in serum osteocalcin, which is only demonstrated by frequent serum sampling. The aim of the present study was to evaluate whether a single dose of inhaled beclomethasone dipropionate causes transient changes in serum osteocalcin, indicating a systemic effect on bone cells. In a double-blind, placebo controlled, cross-over design we evaluated the effects of single doses of 250 \g=m\g and 1000 \g=m\g beclomethasone on the circadian rhythm in serum osteocalcin. Fifteen normal subjects aged 2 3-38 years were studied twice with an interval of one week with hourly blood sampling from 16.30 until 1 7.00 the following day; 1000 \g=m\g beclomethasone, but not 250 \g=m\g,suppressed serum cortisol by 14.4\m=+-\6.7%(p=0.03). Neither of the beclomethasone doses significantly altered the time pattern of serum osteocalcin. We conclude that a single inhaled dose of beclomethasone in the therapeutical range does not acutely influence osteoblastic activity as judged from serial measurements of serum osteocalcin.

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Osteocalcin Levels in Patients with Hyper- and Hypothyroidism

Cited by 31 publications

References 4 publications

Thyroid hormone suppresses the differentiation of osteoprogenitor cells to osteoblasts, but enhances functional activities of mature osteoblasts in cultured rat calvaria cells

Thyroid hormone suppresses the differentiation of osteoprogenitor cells to osteoblasts, but enhances functional activities of mature osteoblasts in cultured rat calvaria cells

BGP Serum Levels in Patients with Thyroid Carcinoma before and 4 — 14 Weeks after Radioiodine Therapy

The effect of single doses of inhaled beclomethasone dipropionate on the circadian rhythm in serum osteocalcin in normals

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