Osteocalcin, ovarian senescence, and brain health

Schatz, Marc; Saravanan, Sharnikha; d’Adesky, Nathan; Bramlett, Helen M.; Pérez-Pinzón, Miguel A.; Raval, Ami P.

doi:10.1016/j.yfrne.2020.100861

Cited by 24 publications

(12 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the mean serum osteocalcin level showed a statistically significant increase in women with POI when compared with apparently healthy control. This finding agreed the study of Singh, Sudhir; etal (15) . Additionally, the mean serum granulin level in POI cases was significantly increased in women with POF.…”

Section: Discussionsupporting

confidence: 94%

The Predictive Value of Osteocalcin, Granulin, Cathepsin K and Some Other Biomarkers in Women with Premature Ovarian Failure

Ibraheem¹,

Mutazsabahahmied²,

Algburi³

et al. 2021

MLU

View full text Add to dashboard Cite

Background: Premature ovarian failure (POF), often and misleadingly referred to as 'premature menopause', is defined as a loss of ovarian activity before the age of 40 years and is characterized by irregular or absent periods and reduced fertility. Symptoms include those associated with the natural menopause (night sweats and vaginal dryness), and with the long-term adverse effects of estrogen deficiency (osteoporosis and cardiovascular disease): the latter is believed to explain the shorter life expectancy associated with POF.Aim: To determinethe predictive value of serum osteocalcin(OC), granulin(GRN), cathepsin k (CTK), vitamin D, parathyroid hormones (PTH), calcium and phosphrus as biomarkers for POF.Method: Sixty (60) women with idiopathic POF with thirty (30) women as control groups were included in the study. Baseline investigation in all subjects included serum Osteocalcin(OC), granulin(GRN), cathepsin k (CTK), vitamin D, parathyroid hormones (PTH), calcium and phosphrus levels were estimated using the appropriate assays for each. Results:The mean serum levels of Osteocalcin, Ganulin,Parathyroid hormones,vitamin D and phosphorus, were significantly higher in women with POF,when compared to healthy controls (P=<0.05). However, mean serum levels of cathepsin k and calcium in POF group were non significant differences,when compared to healthy controls. Conclusion:Osteocalcin and granulin serum levels may be used as new biomarker for the diagnosis of premature ovarian failure.

show abstract

Section: Discussionsupporting

confidence: 94%

The Predictive Value of Osteocalcin, Granulin, Cathepsin K and Some Other Biomarkers in Women with Premature Ovarian Failure

Ibraheem¹,

Mutazsabahahmied²,

Algburi³

et al. 2021

MLU

View full text Add to dashboard Cite

show abstract

“…A study suggests that sex difference is another important factor for AD, which may involve the secretion of female hormones [ 29 ]. The latest report shows that the bone cell-derived hormone osteocalcin (OCN) plays a key role in cognition [ 30 ]. OCN levels are associated with bone density and bone conversion, and therefore are highly affected by changes associated with menopause, increasing risk of disease in menopausal women [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The latest report shows that the bone cell-derived hormone osteocalcin (OCN) plays a key role in cognition [ 30 ]. OCN levels are associated with bone density and bone conversion, and therefore are highly affected by changes associated with menopause, increasing risk of disease in menopausal women [ 30 ]. All of these studies suggest that women are at greater risk of developing dementia in old age, which is consistent with our risk prediction model.…”

Section: Discussionmentioning

confidence: 99%

Construction of a risk prediction model for Alzheimer’s disease in the elderly population

Wang

Hou

et al. 2021

BMC Neurol

View full text Add to dashboard Cite

Background Dementia is one of the greatest global health and social care challenges of the twenty-first century. The etiology and pathogenesis of Alzheimer’s disease (AD) as the most common type of dementia remain unknown. In this study, a simple nomogram was drawn to predict the risk of AD in the elderly population. Methods Nine variables affecting the risk of AD were obtained from 1099 elderly people through clinical data and questionnaires. Least Absolute Shrinkage Selection Operator (LASSO) regression analysis was used to select the best predictor variables, and multivariate logistic regression analysis was used to construct the prediction model. In this study, a graphic tool including 9 predictor variables (nomogram-see precise definition in the text) was drawn to predict the risk of AD in the elderly population. In addition, calibration diagram, receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to verify the model. Results Six predictors namely sex, age, economic status, health status, lifestyle and genetic risk were identified by LASSO regression analysis of nine variables (body mass index, marital status and education level were excluded). The area under the ROC curve in the training set was 0.822, while that in the validation set was 0.801, suggesting that the model built with these 6 predictors showed moderate predictive ability. The DCA curve indicated that a nomogram could be applied clinically if the risk threshold was between 30 and 40% (30 to 42% in the validation set). Conclusion The inclusion of sex, age, economic status, health status, lifestyle and genetic risk into the risk prediction nomogram could improve the ability of the prediction model to predict AD risk in the elderly patients.

show abstract

“…MGP inhibits the calcification of soft tissue and is present in the arterial wall [ 35 ]. Osteocalcin is important for bone health, and recent research has highlighted its additional roles in brain signaling, energy metabolism, and inflammation [ 36 , 37 , 38 ]. Gas6 is widely expressed in the nervous system, and it regulates neuroinflammation and cancer cell signaling [ 39 , 40 ].…”

Section: Comparison Of Vitamins K1 and K2mentioning

confidence: 99%

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

Popescu¹,

German

2021

Nutrients

View full text Add to dashboard Cite

Recent studies have highlighted the importance of vitamin K2 (VK2) in human health. However, there have been no clinical studies investigating the role of VK2 in the prevention or treatment of Alzheimer’s disease (AD), a debilitating disease for which currently there is no cure. In reviewing basic science research and clinical studies that have connected VK2 to factors involved in AD pathogenesis, we have found a growing body of evidence demonstrating that VK2 has the potential to slow the progression of AD and contribute to its prevention. In our review, we consider the antiapoptotic and antioxidant effects of VK2 and its impact on neuroinflammation, mitochondrial dysfunction, cognition, cardiovascular health, and comorbidities in AD. We also examine the link between dysbiosis and VK2 in the context of the microbiome’s role in AD pathogenesis. Our review is the first to consider the physiological roles of VK2 in the context of AD, and, given the recent shift in AD research toward nonpharmacological interventions, our findings emphasize the timeliness and need for clinical studies involving VK2.

show abstract

Osteocalcin, ovarian senescence, and brain health

Cited by 24 publications

References 135 publications

The Predictive Value of Osteocalcin, Granulin, Cathepsin K and Some Other Biomarkers in Women with Premature Ovarian Failure

The Predictive Value of Osteocalcin, Granulin, Cathepsin K and Some Other Biomarkers in Women with Premature Ovarian Failure

Construction of a risk prediction model for Alzheimer’s disease in the elderly population

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

Contact Info

Product

Resources

About