Osteochondral and bone tissue engineering scaffold prepared from Gallus var domesticus derived demineralized bone powder combined with gellan gum for medical application

Kim, David; Cho, Hun Hwi; Thangavelu, Muthukumar; Song, Cheolui; Kim, Han Sol; Choi, Min Joung; Song, Jeong Eun; Khang, Gilson

doi:10.1016/j.ijbiomac.2020.01.191

Cited by 20 publications

(4 citation statements)

References 56 publications

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“…Given the complexity and difficulty in totally mimicking the highly sophisticated native ECM with comparable composition and architecture, decellularization of whole tissues or organs by removing all cells and genetic material while maintaining the physical and biochemical characteristics has emerged as a possible alternative method for cartilage and osteochondral repair [ [201] , [202] , [203] ]. The resulting decellularized extracellular matrix (dECM) can be further processed to serve as a whole scaffold [ [204] , [205] , [206] , [207] , [208] ], a solubilized hydrogel component [ 123 , [209] , [210] , [211] ], a bioink for additive manufacturing [ [212] , [213] , [214] , [215] , [216] ] or pulverized particles for composite scaffold fabrication [ 205 , [217] , [218] , [219] ]. Lin et al produced a biphasic decellularized osteochondral ECM scaffold by combining physical freezing-thawing methods and chemical treatments.…”

Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Wei

Dai

2021

Bioactive Materials

194

161

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In spite of the considerable achievements in the field of regenerative medicine in the past several decades, osteochondral defect regeneration remains a challenging issue among diseases in the musculoskeletal system because of the spatial complexity of osteochondral units in composition, structure and functions. In order to repair the hierarchical tissue involving different layers of articular cartilage, cartilage-bone interface and subchondral bone, traditional clinical treatments including palliative and reparative methods have showed certain improvement in pain relief and defect filling. It is the development of tissue engineering that has provided more promising results in regenerating neo-tissues with comparable compositional, structural and functional characteristics to the native osteochondral tissues. Here in this review, some basic knowledge of the osteochondral units including the anatomical structure and composition, the defect classification and clinical treatments will be first introduced. Then we will highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design, cell encapsulation and signaling factor incorporation including bioreactor application. Clinical products for osteochondral defect repair will be analyzed and summarized later. Moreover, we will discuss the current obstacles and future directions to regenerate the damaged osteochondral tissues.

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Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Wei

Dai

2021

Bioactive Materials

194

161

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“…The severe issue of OCDs gradually evolves from initial joint pain and movement disorder to osteoarthritis, and thus leads to physiologically functional disability. Commonly, articular osteochondral tissue exists significant differences in physiological architecture, mechanical function, and biological microenvironment between cartilage and subchondral bone layers [ 6 , 7 ]. The upper cartilage layer, mainly composed of type II collagen and proteoglycan, presents soft and lubricous tissue surface, which is avascular, aneural, and lacks lymphatic vessels [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Trilayered biomimetic hydrogel scaffolds with dual-differential microenvironment for articular osteochondral defect repair

Chen,

Huang,

et al. 2024

Materials Today Bio

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“…For bone injury, the body can self-repair smaller defects, while larger defects are difficult to repair. For cartilage injury, the low cell density, low metabolic activity and ischemic nature of cartilage make it difficult to regenerate and self-repair [1][2][3]. Although various treatments, such as microfractures, autologous chondrocyte transplants and bone grafts, have been widely used in clinical practice, there are still many limitations and shortcomings, such as the formation of subchondral cysts, rejection of the graft and unsatisfactory long-term effects [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Progress in microsphere-based scaffolds in bone/cartilage tissue engineering

Pan,

Su,

Yao

2023

Biomed. Mater.

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Bone/cartilage repair and regeneration have been popular and difficult issues in medical research. Tissue engineering is rapidly evolving to provide new solutions to this problem, and the key point is to design the appropriate scaffold biomaterial. In recent years, microsphere-based scaffolds have been considered suitable scaffold materials for bone/cartilage injury repair because microporous structures can form more internal space for better cell proliferation and other cellular activities, and these composite scaffolds can provide physical/chemical signals for neotissue formation with higher efficiency. This paper reviews the research progress of microsphere-based scaffolds in bone/chondral tissue engineering, briefly introduces types of microspheres made from polymer, inorganic and composite materials, discusses the preparation methods of microspheres and the exploration of suitable microsphere pore size in bone and cartilage tissue engineering, and finally details the application of microsphere-based scaffolds in biomimetic scaffolds, cell proliferation and drug delivery systems.

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Osteochondral and bone tissue engineering scaffold prepared from Gallus var domesticus derived demineralized bone powder combined with gellan gum for medical application

Cited by 20 publications

References 56 publications

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Trilayered biomimetic hydrogel scaffolds with dual-differential microenvironment for articular osteochondral defect repair

Progress in microsphere-based scaffolds in bone/cartilage tissue engineering

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