Osteochondral Autograft Transfer for Treatment of Osteochondritis Dissecans of the Caudocentral Humeral Head in Dogs

Fitzpatrick, Noel; Terheijden, C. van; Yeadon, Russell; Smith, Thomas J.

doi:10.1111/j.1532-950x.2010.00758.x

Cited by 26 publications

(32 citation statements)

References 48 publications

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“…Osteochondral autograft transfer (OAT) involves the implantation of cores of osteochondral tissue collected from another joint into a recipient bed created from the original OC defect. This approach has led to good short‐term clinical outcomes in dogs with OCD lesions . A discrepancy in the subchondral bone density and a cartilage split‐line pattern mismatch of donor and recipient sites has been identified in stifle to elbow tissue transfers, but the clinical impact of these discrepancies is yet to be established.…”

Section: Introductionmentioning

confidence: 99%

Synthetic osteochondral resurfacing for treatment of large caudocentral osteochondritis dissecans lesions of the humeral head in 24 dogs

Murphy¹,

Egan²,

Fitzpatrick³

2019

Veterinary Surgery

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Objective To report the outcome of dogs with large, caudocentral, osteochondritis dissecans (OCD) lesions of the humeral head treated with synthetic osteochondral resurfacing (SOR) implants. Study design Retrospective case series. Animals Twenty‐four client‐owned large breed or giant dogs. Methods The medical records of all dogs treated with first generation (G1) and second generation (G2) SOR implants were reviewed. All dogs were assessed with clinical examination and imaging 12 weeks after surgery. Assessment of outcome was based on subjective assessment of lameness, scoring of postoperative radiographs, and the Liverpool Osteoarthritis in Dogs (LOAD) questionnaire. Results Osteochondral resurfacing was performed with a G1 implant in 13 dogs (15 shoulders) and a G2 implant in 11 dogs (13 shoulders). Lameness resolved in all dogs treated with G1 implants and in 10 dogs treated with G2 implants by 12 weeks after surgery. One dog treated with a G2 implant was found to have an implant‐associated infection, requiring implant removal. No recurrence of lameness was reported in 9 limbs treated with G1 implants and 10 limbs treated with G2 implants that were available for clinical review at a median time of 387 and 365 days, respectively, after surgery. Mean postoperative LOAD scores were 4.2 of 52 and 5.2 of 52 in dogs treated with a G1 or a G2 implant, respectively. Conclusion Synthetic resurfacing was technically feasible in all joints of this study and resulted in good clinical results. Clinical significance The use of SOR implants seems viable to treat large caudocentral OCD lesions of the humeral head in dogs and warrants prospective comparison with conventional arthroscopic treatment.

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Section: Introductionmentioning

confidence: 99%

Synthetic osteochondral resurfacing for treatment of large caudocentral osteochondritis dissecans lesions of the humeral head in 24 dogs

Murphy¹,

Egan²,

Fitzpatrick³

2019

Veterinary Surgery

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“…A técnica de enxertia osteocondral de origem autógena possibilita o preenchimento do defeito articular com cartilagem hialina própria e livre de reações imunológicas presentes nos enxertos homólogos (Hattori et al 2007, Krusche-Mandl et al 2012, Zak et al 2014, além disso, permite a criação de uma barreira imediata entre o fluido sinovial e osso subcondral, e a reconstituição da superfície articular e da capacidade de suporte de carga do osso subcondral (Bodo et al 2004, Fitzpatrick et al 2010. A restauração do contorno e da congruência articular é desejável na realização do procedimento de enxertia osteocondral, pois influencia de forma direta a função do enxerto e os resultados do tratamento (Cook et al 2008, Böttcher et al 2010.…”

Section: Introductionunclassified

Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos

et al. 2017

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ABSTRACT. - This study aimed to determine the characteristics and applicability of magnetic resonance imaging (MRI) in the evaluation of autogenous osteochondral graft in intact or macerated format, with or without insulin-like growth factor type 1 (IGF-1) used in repair of cartilage lesions induced in rabbits. Nine New Zealand rabbits were used, in which 18 stifle joints underwent grafting procedure in the femoral trochlear groove. These were divided into four groups, referred as intact osteochondral graft + IGF-1 (n=5), intact osteochondral graft + saline solution (n=4), macerated osteochondral graft + IGF-1 (n=5) and macerated osteochondral graft + saline solution (n=4). Animals were euthanized 12 weeks after surgery and the joints were subjected to MRI using a high magnetic field scanner of 1.5 Tesla. In addition, samples of grafting sites were subjected to anatomopathological examination. The MRI was effective as a noninvasive method to evaluate the repair tissue in osteochondral grafts in articular cartilage of the femur of rabbits by providing complementary data to macroscopic and histological examinations. Through these images and anatomopathological examinations satisfactory results were observed in relation to the repair process of autogenous osteochondral grafts in cartilage of rabbits, regardless of its format or the addition of IGF-1. RESUMO.-Este trabalho teve o objetivo de determinar as características e a aplicabilidade do exame de ressonância magnética na avaliação de enxerto ostecondral autógeno, em formato íntegro ou macerado, associado ou não ao fator de crescimento semelhante à insulina tipo 1 (IGF-1), utilizado no reparo de lesões induzidas na cartilagem articular de coelhos. Foram utilizados 9 coelhos da linhagem Nova Zelândia, em que as 18 articulações fêmoro-tíbio-patelares foram submetidas à enxertia osteocondral autógena no sulco troclear femoral. Estas foram divididas em quatro grupos, denominados como enxerto osteocondral íntegro + IGF-1 (n=5), enxerto osteocondral íntegro + solução fisioló-gica (n=4), enxerto osteocondral macerado + IGF-1 (n=5) e enxerto osteocondral macerado + solução fisiológica (n=4). Os animais foram eutanasiados em 12 semanas após a cirurgia e as articulações foram submetidas ao exame de ressonância magnética utilizando um aparelho scanner de 1,5 Tesla de alto campo magnético. Além disso, amostras dos locais de enxertia foram submetidas aos exames anatomopatológicos. O exame de ressonância magnética mostrou--se eficaz como um método não invasivo para avaliação do tecido de reparação em enxertos osteocondrais na cartilagem articular do fêmur de coelhos, fornecendo dados complementares aos exames macroscópicos e histológicos. Por

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“…Surgical strategies for the treatment of osteochondral defects of the stifle include debridement, curettage of the lesion and bone marrow stimulation with microfracture [1], or restorative procedures such as osteochondral autograft transfer (OAT) [2-4]. OAT consists of implanting an osteochondral graft into a recipient bed created at the site of the osteochondral defect [2-4].…”

Section: Introductionmentioning

confidence: 99%

“…OAT consists of implanting an osteochondral graft into a recipient bed created at the site of the osteochondral defect [2-4]. In humans, the therapeutic use of osteochondral grafting has been demonstrated in multiple reports with successful short and long term outcomes reported, even in athletic patients [5-7].…”

Section: Introductionmentioning

confidence: 99%

“…In humans, the therapeutic use of osteochondral grafting has been demonstrated in multiple reports with successful short and long term outcomes reported, even in athletic patients [5-7]. In dogs, the use of OAT for treatment of osteochondrosis lesions of the lateral femoral condyle, medial aspect of the humeral condyle, and caudal humeral head has been performed with good functional outcomes reported [2-4]. …”

Section: Introductionmentioning

confidence: 99%

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Effect of lateral meniscectomy and osteochondral grafting of a lateral femoral condylar defect on contact mechanics: a cadaveric study in dogs

et al. 2013

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BackgroundOsteochondral autograft transfer (OAT) aims at restoring normal articular cartilage surface geometry and articular contact mechanics. To date, no studies have evaluated the contact mechanics of the canine stifle following OAT. Additionally, there are no studies that evaluated the role of the meniscus in contact mechanics following OAT in human or canine femorotibial joints. The objective of this study was to measure the changes in femorotibial contact areas (CA), mean contact pressure (MCP) and peak contact pressure (PCP) before and after osteochondral autograft transplantation (OAT) of a simulated lateral femoral condylar cartilage defect with an intact lateral meniscus and following lateral meniscectomy.ResultsWith an intact lateral meniscus, creation of an osteochondral defect caused a decrease in MCP and PCP by 11% and 30%, respectively, compared to the intact stifle (p < 0.01). With an intact meniscus, implanting an osteochondral graft restored MCP and PCP to 96% (p = 0.56) and 92% (p = 0.41) of the control values. Lateral meniscectomy with grafting decreased CA by 54% and increased PCP by 79% compared to the intact stifle (p < 0.01).ConclusionsOAT restored contact pressures in stifles with a simulated lateral condylar defect when the meniscus was intact. The lateral meniscus has a significant role in maintaining normal contact pressures in both stifles with a defect or following OAT. Meniscectomy should be avoided when a femoral condylar defect is present and when performing OAT.

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Osteochondral Autograft Transfer for Treatment of Osteochondritis Dissecans of the Caudocentral Humeral Head in Dogs

Abstract: OAT procedures are technically feasible in the caudocentral aspect of the canine humeral head. Articular contour reconstruction, resurfacing of osteochondral defects, and amelioration or resolution of short-term lameness may be achieved.

Cited by 26 publications

References 48 publications

Synthetic osteochondral resurfacing for treatment of large caudocentral osteochondritis dissecans lesions of the humeral head in 24 dogs

Synthetic osteochondral resurfacing for treatment of large caudocentral osteochondritis dissecans lesions of the humeral head in 24 dogs

Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos

Effect of lateral meniscectomy and osteochondral grafting of a lateral femoral condylar defect on contact mechanics: a cadaveric study in dogs

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