Osteochondral scaffolds based on electrospinning method: General review on new and emerging approaches

Naghizadeh, Farnaz; Solouk, Atefeh; Khoulenjani, Shadab Bagheri

doi:10.1080/00914037.2017.1393682

Cited by 17 publications

(15 citation statements)

References 76 publications

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“…However, biopolymeric nanofibers have poor mechanical strength and thus they are blended with various other biodegradable materials to obtain better scaffold. Various research groups have investigated the compatibility of the fibrous scaffolds on different tissues or organs [91][92][93][94][95][96][97][98][99][100].…”

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Application of Biopolymeric Electrospun Nanofibers in Biological Science

Shekh

2021

Materials Research Foundations

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Biopolymers are those class of macromolecules which are found in nature or extracted from the living organisms. Various structures and properties of the biopolymers-based materials are well researched till to date. These mainly includes hydrogels, bio glasses, bio inks, biocomposites, fibers and others. These biopolymers-based structures have some limitations. However, Biopolymers have some common advantages (i.e., non-toxicity, easy availability, monodispersity, degradability, and better solubility etc.) and disadvantages (i.e., poor thermal and chemical stabilities, brittleness etc.). To overcome these disadvantages, it is necessary to tailor these polymers by few emerging techniques like “Electrospinning”. Electrospinning is one of the easiest techniques to prepare nanofibers from polymeric solutions by applying high voltage. Obtained nano/micro structural polymeric fibers have good properties like high surface area, porosity and low weights etc. The materials having high surface area and porosity can easily interact with cells and tissues, are better mobile vehicles for drugs, as well as possess good filtration and adsorption abilities. Thus, these one-dimensional structures of the biopolymers are very useful in various fields of biomedical especially water sanitation/desalination, tissue engineering, drug delivery and scaffolds. Various biopolymers like chitosan, chitin, sodium alginate, guar gum, polylactic acid and others are successfully fabricated as fibers and used in various fields of biomedical.

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Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Application of Biopolymeric Electrospun Nanofibers in Biological Science

Shekh

2021

Materials Research Foundations

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“…have been extensively studied in vivo for cartilage tissue engineering. [67,68] One strategy is to use the scaffold to deliver stem cells to the osteochondral defect in the animal model. Poly(caprolactone)polytetrahydrofuran (PCL-PTHF) complemented with collagen or chondroitin sulfate both induced the chondrogenesis of bone marrow-derived MSCs in vitro and in vivo and accelerated cartilage growth.…”

Section: Fibersmentioning

confidence: 99%

The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior

Wang

Hashemi

Stratton

et al. 2020

Adv Healthcare Materials

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Stem cells have been sought as a promising cell source in the tissue engineering field due to their proliferative capacity as well as differentiation potential. Biomaterials have been utilized to facilitate the delivery of stem cells in order to improve their engraftment and long-term viability upon implantation. Biomaterials also have been developed as scaffolds to promote stem cell induced tissue regeneration. This review focuses on the latter where the biomaterial scaffold is designed to provide physical cues to stem cells in order to promote their behavior for tissue formation. Recent work that explores the effect of scaffold physical properties, topography, mechanical properties and electrical properties, is discussed. Although still being elucidated, the biological mechanisms, including cell shape, focal adhesion distribution, and nuclear shape, are presented. This review also discusses emerging areas and challenges in clinical translation.

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“…Electrospinning has been extensively used to fabricate nanofiber membranes for guided tissue regeneration (GTR). [1][2][3][4][5] The membranes can be processed with a wide variety of polymeric and composite materials using simple procedures and instrumentation. 6 The challenge, however, is to produce biodegradable scaffolds with a controllable architecture, porosity, and surface adapted to cellular growth.…”

Section: Introductionmentioning

confidence: 99%

“…18 The HA chemical structure allows several cationic and anionic substitutions that modify the physicochemical and biological properties of hydroxyapatite. 19 Metals such as Sr 2+ , Zn 2+ , Fe 2+ , Mg 2+ , Pb 2+ , and Cd 2+ can substitute the Ca 2+ (I and II sites), while CO 3 2− and F − can substitute the PO 4 3− and OH − groups. In particular, zinc is one of the most important trace elements for human metabolism 20 and can improve HA bioactivity when it is substituted for calcium in the HA structure.…”

Section: Introductionmentioning

confidence: 99%

Structure and biological compatibility of polycaprolactone/zinc-hydroxyapatite electrospun nanofibers for tissue regeneration

Pedrosa

Anjos

Mavropoulos

et al. 2021

Journal of Bioactive and Compatible Polymers

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Although guided tissue regeneration (GTR) is a useful tool for regenerating lost tissue as bone and periodontal tissue, a biocompatible membrane capable of regenerating large defects has yet to be discovered. This study aimed to characterize the physicochemical properties and biological compatibility of polycaprolactone (PCL) membranes associated with or without nanostructured hydroxyapatite (HA) (PCL/HA) and Zn-doped HA (PCL/ZnHA), produced by electrospinning. PCL, PCL/HA, and PCL/ZnHA were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). Nanoparticles of HA or ZnHA were homogeneously distributed and dispersed inside the PCL fibers, which decreased the fiber thickness. At 1 wt% of HA or ZnHA, these nanoparticles acted as nucleating agents. Moreover, HA and ZnHA increased the onset of the degradation temperature and thermal stability of the electrospun membrane. All tested membranes showed no cytotoxicity and allowed murine pre-osteoblast adhesion and spreading; however, higher concentrations of PCL/ZnHA showed less cells and an irregular cell morphology compared to PCL and PCL/HA. This article presents a cytocompatible, electrospun, nanocomposite membrane with a novel morphology and physicochemical properties that make it eligible as a scaffold for GTR.

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Osteochondral scaffolds based on electrospinning method: General review on new and emerging approaches

Cited by 17 publications

References 76 publications

Application of Biopolymeric Electrospun Nanofibers in Biological Science

Application of Biopolymeric Electrospun Nanofibers in Biological Science

The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior

Structure and biological compatibility of polycaprolactone/zinc-hydroxyapatite electrospun nanofibers for tissue regeneration

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