Osteochondritis dessicans: A complex case of anterior knee pain

Davin, John; Selfe, James

doi:10.1016/j.math.2005.05.003

Cited by 2 publications

(1 citation statement)

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“…Osteochondritis dissecans involving the cartilage and bone layers, which results in trauma, joint instability, and insufficient blood flow to the subchondral area, is initiated by osteocartilaginous separation and leads to osteoarthritis (OA), impairment and disability [1]. In addition, once injured, the vascular articular cartilage has poor regenerative capacity compared with other connective tissues.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Biodegradable Scaffolds for Osteochondral Repair on the Immobilized Rabbit Knee

Lin¹,

Chang²,

Yeh³

et al. 2013

Surgery Curr Res

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Background: An initial constrained weight-bearing period achieved via immobilization (Imm) is recommended during osteochondral regeneration to avoid tissue re-injury. However, remedying osteochondral defects with a scaffoldbased treatment and Imm intervention has yet to be studied in osteochondral defect models. Therefore, we investigated the combined outcome of short-term Imm on osteochondral defects with and without porous poly (lactic-co-glycolic acid) (PLGA) scaffold implants. Methods: Twenty-four rabbits were divided into empty defect (ED) and PLGA-implanted (PI) groups. Each rabbit's unilateral knee, which contained an osteochondral defect, was immobilized at full extension with a splint for 2 weeks after surgery and subsequently remobilized until sacrifice at 4 weeks or 12 weeks post surgery. The health status; gross appearance; histological analysis detailing collagen, glycosaminoglycan, and matrix metalloproteinase (MMP)-13 expression levels; and micro-CT images of the rabbits were evaluated. Results: At 4 weeks, the ED and PI groups both exhibited degenerative cartilage features, including an irregular joint surface, fibrous or fibrocartilage formation, decreased glycosaminoglycan (GAG) expression, and increased MMP-13 expression. However, at 12 weeks, the PI group exhibited significantly higher GAG expression, lower MMP-13 expression, and more bony deposition matrix and trabecular bone than the ED group. Conclusion: Our findings indicate that the short-term Imm is harmful to articular cartilage; however, PLGA grafts could provide a matrix for tissue regeneration.

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Section: Introductionmentioning

confidence: 99%