Osteochondritis dissecans (OCD) is a common but poorly understood source of knee pain and dysfunction. It is a condition primarily affecting the subchondral bone, with secondary effects on the articular cartilage surface. A large amount of research over the past two decades has produced many valuable insights into the condition, but further study and elucidation are still needed. The goal of this chapter will be to serve as a general overview of osteochondritis dissecans as it is understood today, including the etiology, clinical presentation, diagnosis, treatment options, outcomes, and future research aims.