Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency?

Gornitzky, Alex L.; Mistovich, Justin; Atuahuene, Brittany; Storey, Eileen; Ganley, Theodore J.

doi:10.1007/s11999-016-5059-x

Cited by 29 publications

(30 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the growing interest in osteochondritis dissecans lesions of the knee(4, 9, 25–27), there is no consensus on incidence of these lesions or the rate of surgical management over time with relation to demographic variables such as age and gender. (1, 2, 5) This population-based study describes the incidence of knee OCD lesions and reports on age- and gender- based trends in incidence in the general population over more than three decades.…”

Section: Discussionmentioning

confidence: 99%

“…28, 29 (33, 34) Both increased activity in males combined with the possibility of increased traumatic events can result in repetitive loading and micro-trauma, which have been shown to be a risk factor for OCD lesions. (5, 6, 8, 9) Lastly, emerging studies have revealed genetics to be an important component and may also contribute to the increased risk in males compared to females. (8, 35, 36)…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County

Pareek

Sanders

et al. 2017

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Objective To (1) define the population-based incidence of OCD lesions of the knee using the population of Olmsted County, (2) examine trends over time, and (3) evaluate changes in the rate of surgical management. Method The study population included 302 individuals who were diagnosed with knee OCD lesions between January 1, 1976 and December 31, 2014. The complete medical records were reviewed to confirm diagnosis and to extract injury and treatment details. Age- and gender-specific incidence rates were calculated and adjusted to the 2010 US population. Poisson regression analyses were performed to examine incidence and surgery trends by age, gender, and calendar period. Results The overall age- and gender-adjusted incidence annual incidence of knee OCD lesions was 6.09 per 100,000 person-years. The incidence was significantly higher (P<0.001) in males (8.82, 95% CI 7.63 to 10.00 per 100,000) compared to females (3.32, 95% CI 2.61 to 4.04 per 100,000). Age- and gender-specific incidence was highest in both males and females in the 11–15 years old at 39.06 and 16.15 per 100,000, respectively. In males aged 11 to 15 years, OCD incidence increased significantly over the study period from 20.68 in 1976–1985 to 48.16 in 2006–2014 (per 100,000). Conclusions The overall age- and gender-adjusted annual incidence of knee OCD lesions in the Olmsted Country Population was 6.09 per 100,000 person-years with a significantly higher incidence in males compared to females. The highest incidence for both males and females occurred between the ages 11 to 15 years. Trends indicate increasing OCD incidence in younger males and decreasing surgical management in females over the last decade.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County

Pareek

Sanders

et al. 2017

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…The levels of evidence of the included studies included: 39 case reports, 31 case series, 11 laboratory studies and 5 comparative studies. Among the included studies, 40 articles proposed a biological hypothesis, 9-47 including genetic causes ( n = 27), ossification center deficit ( n = 12), and endocrine disorders ( n = 9). Conversely, 52 articles supported a mechanical hypothesis, 12,13,17,29,34,35,47…”

Section: Resultsmentioning

confidence: 99%

Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review

et al. 2018

View full text Add to dashboard Cite

Objective The purpose of this manuscript is to analyze the evidence regarding etiopathogenesis of knee osteochondritis dissecans (OCD) lesions through a systematic review, so to summate the current understanding of the origin and progression of this pathologic articular processes. Design A systematic review of the literature was performed on the PubMed and Cochrane databases on October 2017 by 2 independent authors and included all levels of evidence. This included all English language literature, pertaining specifically to etiopathology of knee OCD with exclusions for review articles and expert opinion. Of 965 identified records, 154 full-text articles were assessed for eligibility and 86 studies met the inclusion criteria. Results According to these studies, the etiology of OCD can be of a biological or mechanical origin: 40 articles proposed a biological hypothesis, including genetic causes (27), ossification center deficit (12), and endocrine disorders (9); conversely, 52 articles supported a mechanical hypothesis, including injury/overuse (18), tibial spine impingement (5), discoid meniscus (16), and biomechanical alterations (20) as the cause of the onset of OCD. The pathogenic processes were investigated by 36 of these articles, with a focus on subchondral bone fracture and ischemia as the ultimate events leading to OCD. Conclusions Biological and mechanical factors are found to result in subchondral bone remodeling alterations, acting independently or more likely synergically in the progression of knee OCD. The former includes genetic causes, deficit of ossification centers and endocrine disorders; the latter, tibial spine impingement, discoid meniscus, and biomechanical alterations, together with injuries and overuse. The resultant subchondral bone ischemia and/or fracturing appears to determine the onset and progression of OCD. Level of Evidence Systematic review of level II-IV studies, level IV.

show abstract

“…An increased incidence of JOCD in monozygotic twins suggests a genetic aetiology to JOCD. 2,31,32 In a recent study, 6 the proportion of patients with a positive family history of OCD was 14%. Other researchers have described familial cases of OCD lesions associated with short stature and multiple lesion sites.…”

Section: Aetiologymentioning

confidence: 96%

Juvenile osteochondritis dissecans (JOCD) of the knee: current concepts review

Masquijo

Kothari

2019

EFORT Open Reviews

View full text Add to dashboard Cite

Juvenile osteochondritis dissecans (JOCD) is a joint disorder of the subchondral bone and articular cartilage that affects skeletally immature patients. The aetiology of JOCD is unknown and the natural history is poorly characterized in part due to inconsistent and largely retrospective literature. Most OCD in children and adolescents presents as a stable lesion amenable to non-operative treatment or minimally invasive drilling. However, unstable forms can require a more aggressive approach. This article reviews the most recent literature available and focuses on the pathophysiology, diagnosis and treatment of JOCD of the knee. Cite this article: EFORT Open Rev 2019;4:201-212. DOI: 10.1302/2058-5241.4.180079

show abstract

Osteochondritis Dissecans Lesions in Family Members: Does a Positive Family History Impact Phenotypic Potency?

Abstract: Background Although repetitive microtrauma and athletic overuse patterns are most commonly associated with osteochondritis dissecans (OCD), recent studies have identified a potential genetic predisposition for OCD.

Cited by 29 publications

References 24 publications

Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County

Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County

Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review

Juvenile osteochondritis dissecans (JOCD) of the knee: current concepts review

Contact Info

Product

Resources

About