Osteoclast‐Like Giant Cell Tumor of the Parotid Gland: Report of a Case Diagnosed on Fine‐Needle Aspiration Cytology With Histological and Immunohistochemical Findings

Elhence, Poonam; Rao, Meenakshi; Goyal, Amit; Kumar, Amit; Khera, Pushpinder Singh; Bhattacharya, Susmita

doi:10.1002/dc.23482

Cited by 5 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the plethora of names, the true incidence of UCOGC remains unknown. Tumors with osteoclast-like giant cells have been reported in several extraskeletal sites, such as in the soft tissue, kidneys, breasts, and thyroid and parotid glands (79)(80)(81)(82)(83). Patient clinical presentation is nonspecific and similar to that of PDAC (eg, anorexia, fatigue, weight loss, and jaundice).…”

Section: Clinical Featuresmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Schawkat¹,

Manning²,

Glickman³

et al. 2020

RadioGraphics

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC), an epithelial neoplasm derived from the pancreatic ductal tree, is the most common histologic type of pancreatic cancer and accounts for 85%-95% of all solid pancreatic tumors. As a highly lethal malignancy, it is the seventh leading cause of cancer death worldwide and is responsible for more than 300 000 deaths per year. PDAC is highly resistant to current therapies, affording patients a 5-year overall survival rate of only 7.2%. It is characterized histologically by its highly desmoplastic stroma embedding tubular and ductlike structures. On images, it typically manifests as a poorly defined hypoenhancing mass, causing ductal obstruction and vascular involvement. Little is known about the other histologic subtypes of PDAC, mainly because of their rarity and lack of specific patterns of disease manifestation. According to the World Health Organization, these variants include adenosquamous carcinoma, colloid carcinoma, hepatoid carcinoma, medullary carcinoma, signet ring cell carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, and undifferentiated carcinoma. Depending on the subtype, they can confer a better or even worse prognosis than that of conventional PDAC. Thus, awareness of the existence and differentiation of these variants on the basis of imaging and histopathologic characteristics is crucial to guide clinical decision making for optimal treatment and patient management.

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Schawkat¹,

Manning²,

Glickman³

et al. 2020

RadioGraphics

View full text Add to dashboard Cite

show abstract

“…In contrast, GCT of the parotid (GCTP) is an uncommon tumor with rare, but documented malignant potential that was initially reported in 1984 . Fine needle aspiration of giant cell tumors of the parotid as well as their malignant counterparts have been rarely reported . The similar cytologic features of GCT of TMJ origin and GCTP as well as the proximity in anatomic location of these two entities makes subtyping by aspiration cytology alone impossible.…”

Section: Introductionmentioning

confidence: 99%

“…4 Fine needle aspiration of giant cell tumors of the parotid as well as their malignant counterparts have been rarely reported. [11][12][13][14][15][16] The similar cytologic features of GCT of TMJ origin and GCTP as well as the proximity in anatomic location of these two entities makes subtyping by aspiration cytology alone impossible. Potential clinical consequences result when inaccurate imaging studies lead to incorrect assumptions of the tumor's origin at the time of cytologic interpretation.…”

Section: Introductionmentioning

confidence: 99%

Giant cell tumor of temporomandibular joint presenting as a parotid tumor: Challenges in the accurate subclassification of giant cell tumors in an unusual location

Ren

Mueller²,

Kraft

et al. 2017

Diagnostic Cytopathology

View full text Add to dashboard Cite

Fine needle aspiration is frequently used as the initial diagnostic procedure in the work-up of head and neck lesions, including soft tissue masses and salivary gland neoplasms. Giant cell tumors (GCTs), both osseous and extraosseous, are benign tumors that occur, albeit rarely, in the head and neck region. Extraosseous GCTs may be further classified based on their tissue of origin and specific anatomic location. Regardless of location, giant cell tumors are morphologically similar and share cytologic and histologic diagnostic criteria. Evaluation of imaging is therefore essential to the correct classification of these tumors. Accurate diagnosis is crucial since the clinical behavior and treatment is significantly different among the subtypes of GCTs. The case presented herein illustrates the diagnostic dilemma between two uncommon entities in an unusual site: GCT of parotid gland and tenosynovial GCT.

show abstract

An Operated Case of Pleomorphic Adenoma: Sudden Recurrent Swelling

Dey

2019

Fine Needle Aspiration Cytology

View full text Add to dashboard Cite

Osteoclast‐Like Giant Cell Tumor of the Parotid Gland: Report of a Case Diagnosed on Fine‐Needle Aspiration Cytology With Histological and Immunohistochemical Findings

Cited by 5 publications

References 10 publications

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils

Giant cell tumor of temporomandibular joint presenting as a parotid tumor: Challenges in the accurate subclassification of giant cell tumors in an unusual location

An Operated Case of Pleomorphic Adenoma: Sudden Recurrent Swelling

Contact Info

Product

Resources

About