Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis

Hamie, Lamiaa; Abbas, Ossama; Kurban, Mazen; Bhawan, Jag

doi:10.1097/dad.0000000000001769

Cited by 3 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One recent review by Hamie et al found fewer than 10 cases of melanoma associated with OLGCs, and there are only 3 formerly published cases describing OLGCs in UM. 1,17,18 The expression of typical monocyte/macrophage markers in the absence of melanocytic markers implies a reactive response for OLGCs; at least 2 of the above cases, however, had OLGCs that were positive for HMB-45, Melan-A, and S100, evidence for tumor cell transformation. [17][18][19] In the case of our patient, the abundant OLGCs stained for CD163 but were negative for all other markers.…”

Section: Discussionmentioning

confidence: 99%

“…1,17,18 The expression of typical monocyte/macrophage markers in the absence of melanocytic markers implies a reactive response for OLGCs; at least 2 of the above cases, however, had OLGCs that were positive for HMB-45, Melan-A, and S100, evidence for tumor cell transformation. [17][18][19] In the case of our patient, the abundant OLGCs stained for CD163 but were negative for all other markers. The reason for the occurrence of OLGCs in malignant melanoma, undifferentiated or otherwise, remains to be established.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic Undifferentiated Melanoma Mimicking a Primary Bone Tumor: A Potential Diagnostic Pitfall

Wills,

Dibbern,

Frierson

et al. 2024

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Undifferentiated melanoma (UM) is defined by the loss of classic morphologic and immunohistochemical melanocytic markers. Reports in the literature are rare and show that UM usually occurs as a metastasis in the setting of a known primary cutaneous melanoma. The most common mutations in UM include those involving BRAF, NRAS, and KIT, which are almost invariably present in the parent melanoma. In this study, we report a case of a primary sinonasal melanoma with metastatic UM presenting with osteoclast-like giant cells and resembling a primary bone tumor. The retention of an unusual KRAS mutation in UM that was also present in the primary lesion provided critical information for the diagnosis. Our report highlights the importance of considering mutational analysis to identify undifferentiated melanomas in patients with metastatic tumors which do not have the typical histopathologic and immunohistochemical features of melanoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metastatic Undifferentiated Melanoma Mimicking a Primary Bone Tumor: A Potential Diagnostic Pitfall

Wills,

Dibbern,

Frierson

et al. 2024

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…Although the pathogenesis of GCT-ST remains uncertain, OGCs that recruit lesions by RANKL expression are considered to play an important role [ 7 ]. Several authors suggested that a chronic inflammatory condition may be associated with OGC proliferation [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of soft tissue of the colon: a case report and review of the literature

Lee

Kim

et al. 2022

BMC Gastroenterol

View full text Add to dashboard Cite

Background A giant cell tumor (GCT) is a benign neoplasm characterized by mixture of mononuclear cells and multinucleated cells. A GCT of soft tissue (GCT-ST) is developed in various extraosseous sites, but GCT-ST of the gastrointestinal tract is very rare. GCT-ST usually has a benign course, but rare cases reported malignant potential of the tumor. Therefore, complete resection is required to prevent local recurrence or distant metastasis. Case presentation A 53-year-old woman was admitted for follow-up colonoscopy who underwent the colorectal endoscopic submucosal dissection (ESD) of a laterally spreading tumor at the hepatic flexure 6 months ago. A colonoscopy showed a polypoid mass about 3.5 × 2.5 cm at the previous ESD site. As endoscopic finding showed a smooth multi-nodular tumor without submucosal invasion, we performed endoscopic mucosal resection. Based on pathological and immunohistochemical findings, the lesion was diagnosed as a GCT-ST in the colon. Follow-up colonoscopy performed 6 months later revealed no evidence of recurrence. Conclusion This is the first report of a GCT-ST identified in the colon. Although GCT-ST generally has a benign clinical course, complete resection should be performed to prevent local recurrence and metastasis.

show abstract

Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis

2022

View full text Add to dashboard Cite

The ossifying variant and the granular cell variant are rare subtypes of cutaneous fibrous histiocytoma (CFH), characterized by islands of mature metaplastic bone tissue rimmed by multinucleated osteoclast-like giant cells and by large-sized cells with granular cytoplasm and mildly hyperchromatic nuclei with inconspicuous nucleoli, respectively. We herein present two cases of these unusual CFH variants in a 37-year-old woman and in a 38-year-old man, respectively. The main differential diagnoses, including both benign and malignant lesions, are also discussed.

show abstract

Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis

Cited by 3 publications

References 47 publications

Metastatic Undifferentiated Melanoma Mimicking a Primary Bone Tumor: A Potential Diagnostic Pitfall

Metastatic Undifferentiated Melanoma Mimicking a Primary Bone Tumor: A Potential Diagnostic Pitfall

Giant cell tumor of soft tissue of the colon: a case report and review of the literature

Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis

Contact Info

Product

Resources

About