2001
DOI: 10.1006/bbrc.2001.4307
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Osteoclasts Secrete the Chemotactic Cytokine Mim-1

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Cited by 29 publications
(19 citation statements)
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“…We presume that these changes in gene expression might be associated with signaling pathways caused by PEMFs. The activation of a series of biological eVects and the release of signaling molecules may modulate various cellular functions [42,43], including changes in the mRNA expression of multiple genes [44], and some of these regulators can be modulated by PEMFs [45][46][47]. Although the potential for exogenous EMF to inhibit bone loss is not well understood, the gene expression of RANK and CAII might be one of the targets of electromagnetic Welds.…”
Section: Discussionmentioning
confidence: 99%
“…We presume that these changes in gene expression might be associated with signaling pathways caused by PEMFs. The activation of a series of biological eVects and the release of signaling molecules may modulate various cellular functions [42,43], including changes in the mRNA expression of multiple genes [44], and some of these regulators can be modulated by PEMFs [45][46][47]. Although the potential for exogenous EMF to inhibit bone loss is not well understood, the gene expression of RANK and CAII might be one of the targets of electromagnetic Welds.…”
Section: Discussionmentioning
confidence: 99%
“…Sequence analysis of the proteins was performed in the Mass Spectrometry Core Facility at the Beckman Research Institute of the City of Hope (Duarte, Calif.). The gel-separated proteins were reduced, alkylated, and digested in the gel as described in published procedures (9). Tryptic peptides were extracted and analyzed with a custom-built nano flow high-performance liquid chromatography system (8) coupled to an LCQ Classic Ion Trap mass spectrometer (ThermoFinnigan, San Jose, Calif.).…”
Section: Methodsmentioning
confidence: 99%
“…Second, growth factors such as transforming growth factor β (TGF-β), released from the bone matrix during the resorption process, participate in regulating osteoblast differentiation and function (Figure 1) (22, 23), thereby coupling bone formation to bone resorption. Interestingly, accumulating evidence suggests that osteoclasts play a role in the coupling of bone formation to bone resorption by producing factors that stimulate osteoblast differentiation and function (Figure 1) (2426). Finally, the BRC may also serve as a physical mechanism for coupling bone formation to bone resorption by confining the two biological processes in a closed compartment (19).…”
Section: Basic Biology Of Bone Remodelingmentioning
confidence: 99%