Osteoconductive and Osteoinductive Implants Composed of Hollow Hydroxyapatite Microspheres

Rahaman, Mohamed N.; Xiao, Wei; Liu, Yongxing; Bal, B. Sonny

doi:10.1002/9781119040392.ch7

Cited by 5 publications

(3 citation statements)

References 68 publications

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“…Some studies have included hydroxyapatite (HA) in the DBM group or autobone group. Particularly, since the components of HA do not contain BMP and their direct osteoinduction ability is substantially low, they are included in the study [ 17 , 18 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis

Han

Park

Lim

et al. 2020

J Korean Neurosurg Soc

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The demineralized bone matrix (DBM) as the bone graft material to increase the fusion rate was widely used in spinal fusion. The current study aimed to compare the fusion rate of DBM to the fusion rate of autograft in lumbar spine fusion via meta-analysis of published literature. After systematic search, comparative studies were selected according to eligibility criteria. Checklist (risk of bias assessment tool for non-randomized study) was used to evaluate the risk of bias of the included nonrandomized controlled studies. The corresponding 95% confidence interval (95% CI) were calculated. We also used subgroup analysis to analyze the fusion rate of posterolateral lumbar fusion and lumbar interbody fusion. Eight studies were finally included in this meta-analysis. These eight studies included 581 patients. Among them, 337 patients underwent spinal fusion surgery using DBM (DBM group) and 204 patients underwent spinal fusion surgery with mainly autologous bone and without using DBM (control group). There was no significant differences of fusion rate between the two groups in posterolateral fusion analysis (risk ratio [RR], 1.03; 95% CI, 0.90-1.17; p=0.66) and interbody fusion analysis (RR, 1.13; 95% CI, 0.91-1.39; p=0.27). Based on the available evidence, the use of DBM with autograft in posterolateral lumbar spine fusion and lumbar interbody fusion showed a slightly higher fusion rate than that of autograft alone; however, there was no statistically different between two groups.

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Section: Discussionmentioning

confidence: 99%

Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis

Han

Park

Lim

et al. 2020

J Korean Neurosurg Soc

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“…HA cuts the contact of metal ions with the body and prevents the release of ions into the body [2,5,19]. Also, the osteoconductive feature of HA enables implants to adhere tightly to the bone [20][21][22]. HA is the most widely used bioactive substance, supporting bone growth [2,14,23,24].…”

Section: Introductionmentioning

confidence: 99%

"Investigation of the effect of shot blasting on the surface properties of the HA coatings processed by the EPD method "

Bahçepınar¹,

Aydin²

2022

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316L stainless steel implant material surfaces shot blasted with glass beads underwent hydroxyapatite (HA) coating process by electrophoretic deposition method (EPD). The mechanical and metallographic test results of HA coatings applied to the shot blasted and sanded substrates have been discussed. The sanded process was carried out with 320 Grit SiC sandpaper. Shot blasted process was carried out in a vacuum shot blasting machine at 5 bar pressure with glass beads. Ethanol was used as a solvent during the coating process. The coating solution was prepared by mixing ethanol, HA, PVA, and N, N-Dimethylformamide chemicals in specific ratios to have a steady suspension. Regarding tests conducted on HA coatings, it was revealed that shot blasted surfaces had better results when compared to those of sanded surfaces. Hopefully, this new process for coatings will be a new impression for future studies.

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“…The changes in structure can influence on the biological tests in return. We sporadically observed that there tended to be better bone regeneration with broken closed microspheres with micro-concavity [15, 17]. This observation motivated us to design this study that focused on enhanced bone regeneration with open microspheres.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Open Hollow Hydroxyapatite Microsphere on Bone Regeneration in Rat Calvarial Defects

Yan

Rahaman

Liu

et al. 2019

Preprint

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2Hollow hydroxyapatite (HA) microspheres showed the ability to facilitate bone regeneration 3 in rats with non-healing calvarial defects. However, new bone formation in the rat calvarial defect 4 implanted with the closed HA microspheres was limited. The objective of this work is to evaluate 5 size-, time, and structure-dependent bone regeneration between open and closed HA microspheres in 6 an osseous model. Open HA microspheres were obtained by sectioning closed HA microspheres. 7 The open HA microsphere had dense convex surface and rough and porous concave surface. For 8 both size ranges (ϕ106-150 μm vs. ϕ212-250 μm), the open HA microsphere were more effective in 9 facilitating bone regeneration than the closed HA microspheres in rat calvarial defects. Bone 10 regeneration in the open HA microspheres (49 ± 7% for ϕ106-150 μm; 40 ± 8% for ϕ212-250 μm)11 were higher than the closed HA microsphere (26 ± 8% for ϕ106-150 μm; 30 ± 9% for ϕ212-250 μm)12 at 12 weeks. Furthermore, the open HA microspheres of smaller size showed a significant increase in 13 bone regeneration than the open HA microspheres of larger size at both 6 weeks and 12 weeks. The 14 difference in bone regeneration between these microspheres could be due to their differences in 15 microstructures, namely curvature, concavity, porosity, surface roughness, and total surface area 16 available for cells to attached to.

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Osteoconductive and Osteoinductive Implants Composed of Hollow Hydroxyapatite Microspheres

Cited by 5 publications

References 68 publications

Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis

Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis

"Investigation of the effect of shot blasting on the surface properties of the HA coatings processed by the EPD method "

Evaluation of Open Hollow Hydroxyapatite Microsphere on Bone Regeneration in Rat Calvarial Defects

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