Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects

Abstract

Calcium phosphate glass (CPG) is well-documented alloplastic bone graft material. The objective of this study was to evaluate the osteoconductive effect of newly developed calcium phosphate glass cement (CPGC) in rabbit calvarial defects. Three circular defects (8 mm diameter) were created on the rabbit calvarium. One defect was filled with biphasic calcium phosphate (BCP group) and one defect was filled with CPGC (CPGC group). The remaining defect was not filled as the control. Histologic and histometric analysis were performed at four and eight weeks following the implantation of materials. One-way ANOVA method was used to evaluated the significance between three groups (p < 0.05). The CPGC group did not show a statistical difference in new bone area compared with the control at all healing periods, but the bone formation rate of CPGC seemed to increase between four and eight weeks. This suggests the bone formation rate of CPGC is initially slow, but increases at a specific time, showing the possibility of greater bone formation with time. The resorption rate of CPGC was greater than BCP. Within the limits of this study, CPGC demonstrated good space maintaining capacity and had an osteoconductive effect, suggesting it could be successfully used to improve bone formation capacity.

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

“…The histologic and histometric results obtained in this study show that the three forms of Ca‐P ceramic maintained space more effectively than the control condition, which is consistent with the results of our previous studies . The usefulness of residual bone graft materials can vary with the type of defect to which the materials are applied.…”

“…The histologic and histometric results obtained in this study show that the three forms of Ca-P ceramic maintained space more effectively than the control condition, which is consistent with the results of our previous studies. 22,23 The usefulness of residual bone graft materials can vary with the type of defect to which the materials are applied. For instance, in the case of the bone graft materials used for deficient bone volume, as in the present study, maintenance of the grafted volume is necessary for bone augmentation.…”

Paracrine effect of the bone morphogeneticprotein-2 at the experimental site on healing of the adjacent control site: a study in the rabbit calvarial defect model

“…A CSD is defined as the smallest defect that would not heal spontaneously without intervention for a certain period of healing [14], or which results in less than 10% bone healing during the remaining life span of the experimental animal [15]. The size of CSDs in the rabbit is reportedly up to 17 mm×17 mm [16]; however, many studies have adopted circular 8-, 6-, and even 5-mm defects [2,7,17,18]. Circular 8-mm diameter defects were chosen for the present study.…”

“…Several circular defects can be made on the rabbit calvarium, with the sizes of the defects being determined according to the characteristics of the biomaterials being used, the healing period, and more importantly, the aim of individual studies [6,7,8]. For example, circular 8-mm defects were created for evaluating a newly developed bone-graft material, with the treatment modality and the number of defects created differing between studies [1,6,7]. Rabbit calvaria have also been used for evaluating growth factors such as rhBMP-2 [2,9].…”

Effect of platelet-rich plasma on bone engineering with an alloplastic substitute containing BMP2

“…However, allografts, xenografts, or alloplastic bone substitutes are currently employed in clinics because autografts involve donor site morbidity and may lack osteogenic potential [5,[7][8][9]. Such alloplastic substitutes have excellent biocompatible and osteoconductive abilities, but they lack osteoinductive properties [10,11]. Such alloplastic substitutes have excellent biocompatible and osteoconductive abilities, but they lack osteoinductive properties [10,11].…”