Osteoconductive properties of poly(96L/4D-lactide)/beta-tricalcium phosphate in long term animal model

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

“…Both dense and porous composites based on β-TCP have been demonstrated to show excellent performance in the physiological environment and possess several advantages over other calcium phosphates especially with regard to bioresorption [31][32][33][34][35][36]. In contrast only a few papers have been published on the fabrication of electrospun biodegradable hybrid fiber meshes containing β-TCP as inorganic component.…”

Irradiation of bioresorbable biomaterials for controlled surface degradation

“…An earlier commencement of release of the β-TCP would allow for earlier osteosynthesis, during the crucial phase on bone healing (the first 8 weeks in vivo) [Kalfas, 2001] as there is greater control over the timing of the release of the β-TCP [Daculsi et al, 2003;Daculsi et al 2011]. The accelerated study was conducted for 28 days, and it is possible to speculate that, once the modified surface has degraded, degradation of the remainder of the sample will proceed as normal.…”

“…Increasingly additives such as calcium fillers and anti-microbials are being incorporated into polyhydroxyacid implants for use in orthopaedics [Ashammakhi et al, 2006;Daculsi et al, 2011]. Integrating bioactive ceramics into bioresorbable polymers is advantageous for the biocompatibility and osteointegration of the implant.…”

Degradation and swelling issues of poly-(d,l-lactide)/β-tricalcium phosphate/calcium carbonate composites for bone replacement

“…However, the lack of osteoconductive properties (Daculsi et al, 2011;Prokop et al, 2005) (Schiller and Epple, 2003) are obstructive with regard to the healing after implantation. The in vivo investigations about different polylactides have demonstrated the building of a thin layer of connective tissue around the implant (Gerlach, 1993;Mainil-Varlet et al, 1996), preventing the direct connection between bone and implant (MainilVarlet et al, 1996;Daculsi et al, 2011). Inflammatory reactions were promoted immediately after implantation (Gerlach, 1993;Mainil-Varlet et al, 1996).…”