2024
DOI: 10.3389/fphys.2024.1364694
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Osteocyte-mediated mechanical response controls osteoblast differentiation and function

Heather VerValin Buck,
Joseph Paul Stains

Abstract: Low bone mass is a pervasive global health concern, with implications for osteoporosis, frailty, disability, and mortality. Lifestyle factors, including sedentary habits, metabolic dysfunction, and an aging population, contribute to the escalating prevalence of osteopenia and osteoporosis. The application of mechanical load to bone through physical activity and exercise prevents bone loss, while sufficient mechanical load stimulates new bone mass acquisition. Osteocytes, cells embedded within the bone, receive… Show more

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