Osteogenesis of the human upper jaw: Proof of the non-existence of a separate premaxillary centre

Rapid Maxillary Expansion after Secondary Alveolar Bone Grafting in Patients with Alveolar Cleft

“…Therefore, there may be a midpalatal suture in the premaxilla of patients with complete alveolar clefts. Although there is no agreement regarding the existence of the premaxillary suture in human beings, studies showing the nonexistence of a totally independent premaxillary suture have described the ''incisive fissure'' (Wood et al, 1969;Behrents and Harris, 1991;Nijo and Kjaer, 1993). The incisive suture is located in the anterior region of the premaxilla and originated embryologically from the primary palate.…”

A Histochemical Study of the Development of Premaxilla and Maxilla during Secondary Palate Formation in the Mouse Embryo.

“…A cluster of mesenchymal cells differentiates into osteoid-secreting osteoblasts, and direct bone formation takes place without any prior formation of cartilage (JEE, 1983). Though there are reports on the ossification of the premaxilla and maxilla (DIXON, 1958;KRAUS and DECKER, 1960;KVINNSLAND, 1969;WooD et al, 1969), cytodifferentiation in the early stage has yet to be clarified. This study demonstrated, using ALPase activity, that the initial development of the premaxilla and maxilla is related to the differentiation of the adjacent tissue.…”

Palatal growth in baboons (Papio cynocephalus anubis)

“…Though many published reports include information on normal postnatal development of the human palate (e.g., KROGMAN, 1961 ;SCOTT, 1967;ENLOW, 1982;MOORE & LAVELL~, 1974), more extensive literature focuses on the embryology and the pathology of the palate (e.g., WOOD et al, 1969;LAVELLE & MOO~.E, 1970;LANCMAN, 1975;MAtrSEg et al, 1975;BHASKAR, 1976). Given this state of affairs with regard to humans, it is not altogether surprising that relatively few comprehensive studies about the morphogenesis of the palate in non-human primates have been reported.…”