Osteogenetic Activity of Transplanted Transitional Epithelium

Friedenstein, A. J.

doi:10.1159/000141739

Cited by 71 publications

(39 citation statements)

References 4 publications

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“…The gold standard assay utilized to identify MSCs is the colony forming unit-fibroblast (CFU-F) assay which, at minimum, identifies adherent, spindle-shaped cells that proliferate to form colonies [6]. Some of the earliest experimental evidence supporting the existence of MSCs originated from the pioneering work of Friedenstein et al, who first demonstrated that bone marrow derivedcells were capable of osteogenesis [7]. Accordingly, this assay has been used as an in vitro correlate for MSC potential.…”

Section: Existence Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy

Baksh

Lin

Tuan

2004

J Cellular Molecular Medi

945

630

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A considerable amount of retrospective data is available that describes putative mesenchymal stem cells (MSCs). However, there is still very little knowledge available that documents the properties of a MSC in its native environment. Although the precise identity of MSCs remains a challenge, further understanding of their biological properties will be greatly advanced by analyzing the mechanisms that govern their self-renewal and differentiation potential. This review begins with the current state of knowledge on the biology of MSCs, specifically with respect to their existence in the adult organism and postulation of their biological niche. While MSCs are considered suitable candidates for cell-based strategies owing to their intrinsic capacity to self-renew and differentiate, there is currently little information available regarding the molecular mechanisms that govern their stem cell potential. We propose here a model for the regulation of MSC differentiation, and recent findings regarding the regulation of MSC differentiation are discussed. Current research efforts focused on elucidating the mechanisms regulating MSC differentiation should facilitate the design of optimal in vitro culture conditions to enhance their clinical utility cell and gene therapy.

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Section: Existence Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy

Baksh

Lin

Tuan

2004

J Cellular Molecular Medi

945

630

View full text Add to dashboard Cite

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“…The notion of MSCs was introduced in 1961 by Friedenstein (154) who documented that marrow stroma cells contain osteogenic progenitors. Subsequently, the culture conditions necessary for the expansion and differentiation of this cell category were developed.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Cardiac Stem Cells and Mechanisms of Myocardial Regeneration

Leri

Kajstura²,

Anversa³

2005

Physiological Reviews

399

349

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This review discusses current understanding of the role that endogenous and exogenous progenitor cells may have in the treatment of the diseased heart. In the last several years, a major effort has been made in an attempt to identify immature cells capable of differentiating into cell lineages different from the organ of origin to be employed for the regeneration of the damaged heart. Embryonic stem cells (ESCs) and bone marrow-derived cells (BMCs) have been extensively studied and characterized, and dramatic advances have been made in the clinical application of BMCs in heart failure of ischemic and nonischemic origin. However, a controversy exists concerning the ability of BMCs to acquire cardiac cell lineages and reconstitute the myocardium lost after infarction. The recognition that the adult heart possesses a stem cell compartment that can regenerate myocytes and coronary vessels has raised the unique possibility to rebuild dead myocardium after infarction, to repopulate the hypertrophic decompensated heart with new better functioning myocytes and vascular structures, and, perhaps, to reverse ventricular dilation and wall thinning. Cardiac stem cells may become the most important cell for cardiac repair.

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“…2). Although multiple cell sources are available, adult MSCs are highly preferred for cartilage tissue engineering due to the report that bone marrow-derived mesenchymal stem cells (BM-MSC) are capable of osteogenesis (11). Recently, adult adipose-derived stem cells (ASCs) were suggested as another cell source for cartilage repair, because of ease of isolation and multiple differentiation potentials.…”

Section: Cell Sourcesmentioning

confidence: 99%

Stem Cell-assisted Approaches for Cartilage Tissue Engineering

Park¹,

Cho²

2010

Int J Stem Cells

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The regeneration of damaged articular cartilage remains challenging due to its poor intrinsic capacity for repair. Tissue engineering of articular cartilage is believed to overcome the current limitations of surgical treatment by offering functional regeneration in the defect region. Selection of proper cell sources and ECM-based scaffolds, and incorporation of growth factors or mechanical stimuli are of primary importance to successfully produce artificial cartilage for tissue repair. When designing materials for cartilage tissue engineering, biodegradability and biocompatibility are the key factors in selecting material candidates, for either synthetic or natural polymers. The unique environment of cartilage makes it suitable to use a hydrogel with high water content in the cross-linked or thermosensitive (injectable) form. Moreover, design of composite scaffolds from two polymers with complementary physicochemical and biological properties has been explored to provide residing chondrocytes with a combination of the merits that each component contributes.

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Osteogenetic Activity of Transplanted Transitional Epithelium

Cited by 71 publications

References 4 publications

Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy

Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy

Cardiac Stem Cells and Mechanisms of Myocardial Regeneration

Stem Cell-assisted Approaches for Cartilage Tissue Engineering

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