Tissue repair is an extremely complex process, and effectively promoting tissue regeneration remains a significant clinical challenge. Hydrogel materials, which exhibit physical properties closely resembling those of living tissues, including high water content, oxygen permeability, and softness, have the potential to revolutionize the field of tissue repair. However, the presence of various complex conditions, such as infection, ischemia, and hypoxia in tissue defects, means that hydrogels with simple structures and functions are often insufficient to meet the diverse needs of tissue repair. Researchers have focused on integrating multiple drugs, nanomaterials, bioactive substances, and stem cells into hydrogel matrices to develop novel multifunctional composite hydrogels for addressing these challenges, which have superior antibacterial properties, hemostatic abilities, self-healing capacities, and excellent mechanical properties. These composite hydrogels are designed to enhance tissue repair and have become an important direction in the current research. This review provides a comprehensive review of the recent advances in the application of multifunctional composite hydrogels in promoting tissue repair, including drug-loaded hydrogels, nanomaterial composite hydrogels, bioactive substance composite hydrogels, and stem cell composite hydrogels. Recent research indicates that novel tissue engineering biomaterials, designed to mimic the structure, mechanical properties, and biological characteristics of natural tissues, hold significant promise for improving treatment outcomes in patients with tissue defects.Clinically common tissue defects include skin, nerve, and bone defects, and so on. The skin, as the largest organ of the human body, comprises three interconnected layers: the epidermis, dermis, and subcutaneous tissue, arranged sequentially from the outermost to the innermost layer. It has been found to play vital roles in protection, sensation, secretion, and metabolism. 2,3 The advancement of tissue engineering and regenerative medicine has resulted in the development and clinical application of various artificial skin products, including
